Nefopam HCl

For research use only.

Catalog No.S4180

Nefopam HCl Chemical Structure

Molecular Weight(MW): 289.8

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.

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Biological Activity

Description Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.
In vitro

The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine. [1]

In vivo Using the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. . [2]

Protocol

Solubility (25°C)

In vitro Water 21 mg/mL (72.46 mM)
DMSO 1 mg/mL (3.45 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 289.8
Formula

C17H19NO.HCl

CAS No. 23327-57-3
Storage powder
in solvent
Synonyms N/A
Smiles Cl.CN1CCOC(C2=CC=CC=C2)C3=C(C1)C=CC=C3

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04241640 Not yet recruiting Drug: Nefopam 20 MG/ML|Drug: Placebo Pain Postoperative Mahidol University July 2020 Phase 4
NCT03889288 Recruiting Device: Medical device - electronic-pain killer Aortic Valve Replacement University Hospital Grenoble|Remedee Labs|Clinical Investigation Centre for Innovative Technology June 16 2019 Not Applicable
NCT01685658 Suspended Drug: Intravenous ketoprofen|Drug: Intravenous paracetamol Renal Colic|Acute Renal Colic Centre Hospitalier Universitaire de Nīmes September 2016 Phase 4
NCT02796547 Withdrawn Drug: Levobupivacaine|Other: Physiological serum Episiotomy Brugmann University Hospital July 14 2016 Phase 2
NCT03102515 Completed Drug: USG-TAP block|Drug: CIC Postoperative Pain University Hospital Caen May 29 2016 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID