Nefopam HCl

Catalog No.S4180

For research use only.

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.

Nefopam HCl Chemical Structure

CAS No. 23327-57-3

Purity & Quality Control

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Biological Activity

Description Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.
In vitro

The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine. [1]

In vivo Using the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. . [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 21 mg/mL
(72.46 mM)
DMSO 1 mg/mL
(3.45 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 289.8
Formula

C17H19NO.HCl

CAS No. 23327-57-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04685577 Not yet recruiting Drug: Nefopam|Other: Placebo (Vehicle) Burn; Multiple Body Regions Max. Second Degree|Third-Degree Burn|Burn Degree Second University of Alberta January 2022 Phase 2
NCT04576078 Not yet recruiting Drug: Oral nefopam|Drug: Placebo Postoperative Pain After a High Tibial Osteotomy Hospices Civils de Lyon October 2020 Phase 2
NCT04241640 Recruiting Drug: Nefopam 20 MG/ML|Drug: Placebo Pain Postoperative Mahidol University September 1 2020 Phase 4
NCT04478253 Recruiting Device: HypnoVR Pneumopathy GCS Ramsay Santé pour l''Enseignement et la Recherche May 23 2020 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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