Nystatin (Fungicidin)

Catalog No.S1934

Nystatin (Fungicidin) Chemical Structure

Molecular Weight(MW): 1056.24

Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.

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Biological Activity

Description Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
In vitro

Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six Candida species. [1] Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. [2] Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. [3]

In vivo Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. [3] Liposomal Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. [4]

Protocol

Solubility (25°C)

In vitro DMSO 19 mg/mL (17.98 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1056.24
Formula

C53H85NO20

CAS No. 62997-67-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03862079 Not yet recruiting Allogeneic Hematopoietic Stem Cell Transplantation Recipient M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 21 2019 Phase 2
NCT03862079 Not yet recruiting Allogeneic Hematopoietic Stem Cell Transplantation Recipient M.D. Anderson Cancer Center|National Cancer Institute (NCI) May 21 2019 Phase 2
NCT02186145 Unknown status Bacterial Vaginosis|Fungal Vaginal Infections Marjan Industria e Comercio ltda January 2016 Phase 3
NCT02186145 Unknown status Bacterial Vaginosis|Fungal Vaginal Infections Marjan Industria e Comercio ltda January 2016 Phase 3
NCT02662374 Unknown status Oral Mucositis Riyadh Colleges of Dentistry and Pharmacy|King Faisal Specialist Hospital & Research Center September 2015 Phase 4
NCT02662374 Unknown status Oral Mucositis Riyadh Colleges of Dentistry and Pharmacy|King Faisal Specialist Hospital & Research Center September 2015 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID