Nystatin (Fungicidin)

Catalog No.S1934

For research use only.

Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.

Nystatin (Fungicidin) Chemical Structure

CAS No. 62997-67-5

Selleck's Nystatin (Fungicidin) has been cited by 11 Publications

Purity & Quality Control

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Biological Activity

Description Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
In vitro

Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six Candida species. [1] Nystatin is an antibiotic that increases the permeability of plasma membranes to small monovalent ions, including chloridion. Nystatin increases apical chloridion permeability to the point where transepithelial chloridion transport is limited by transport across the basolateral membrane of tracheal epithelial cells, which reflects primarily the activity of the cotransporter. Nystatin (400 units/ml) increases the basal level of transepithelial 36Cl flux approximately 1.5-fold and eliminates UTP stimulation of this flux. Nystatin treatment also abolishes UTP stimulation of saturable, basolateral [3H]bumetanide binding, a measure of functioning Na-K-Cl cotransporters in these cells; isoproterenol stimulation of binding is only mildly inhibited by nystatin treatment. [2] Nystatin significantly enhances endostatin uptake by endothelial cells through switching endostatin internalization predominantly to the clathrin-mediated pathway. Nystatin-enhanced internalization of endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. [3]

In vivo Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo. [3] Liposomal Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 1056.24
Formula

C53H85NO20

CAS No. 62997-67-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1OC3CC(C(C(O3)C)O)O)C)C)O)O)O)O)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01531192 Completed Dietary Supplement: Lactobacillus reuteri|Drug: Nystatin Very Low Birth Weight Infants Zekai Tahir Burak Women''s Health Research and Education Hospital June 2012 Phase 4
NCT01411748 Unknown status Dietary Supplement: Reflor|Drug: mikostatin Anticandidal Property of Saccharomyces Boulardii on Very Low Birth Weight Infants Zekai Tahir Burak Women''s Health Research and Education Hospital July 2011 Phase 4
NCT01427738 Completed Drug: Gentian Violet|Drug: Nystatin oral suspension HIV-1 Infection AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) June 2011 Phase 3
NCT03390374 Completed Drug: Nystatin Oral Fungal Infections Systemic Dr Cipto Mangunkusumo General Hospital October 2010 Phase 4
NCT02642900 Completed Procedure: Photodynamic Therapy|Drug: Nystatin 100.000 units Photochemotherapy Reaction University of Sao Paulo July 2009 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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