For research use only.

Catalog No.S3105 Synonyms: OPC-7251

1 publication

Nadifloxacin  Chemical Structure

CAS No. 124858-35-1

Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.

Selleck's Nadifloxacin has been cited by 1 publication

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Choose Selective Antibiotics Inhibitors

Biological Activity

Description Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.
In vitro

Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis.


Solubility (25°C)

In vitro DMSO 20 mg/mL (55.49 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.38


CAS No. 124858-35-1
Storage powder
in solvent
Synonyms OPC-7251
Smiles CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O

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