Catalog No.S3105 Synonyms: OPC-7251

For research use only.

Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.

Nadifloxacin  Chemical Structure

CAS No. 124858-35-1

Selleck's Nadifloxacin has been cited by 1 Publication

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Biological Activity

Description Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.
In vitro

Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 360.38


CAS No. 124858-35-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O

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