NOTA

Catalog No.S6923

For research use only.

NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a bifunctional chelating agent that has attracts the interest of the scientific community for its high complexation constant with metals like gallium.

NOTA Chemical Structure

CAS No. 56491-86-2

Purity & Quality Control

Choose Selective Hydrotropic Agents Inhibitors

Biological Activity

Description NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a bifunctional chelating agent that has attracts the interest of the scientific community for its high complexation constant with metals like gallium.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 61 mg/mL
(201.11 mM)
Water 50 mg/mL
(164.84 mM)
Ethanol 2 mg/mL
(6.59 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 303.31
Formula

C12H21N3O6

CAS No. 56491-86-2
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05001204 Recruiting Drug: 68Ga-NOTA-RM26 Gastrointestinal Stromal Tumors Peking Union Medical College Hospital May 1 2021 Early Phase 1
NCT04552847 Recruiting Drug: Al18F-NOTA-octreotide|Device: PET/CT|Device: PET/MR Neuroendocrine Tumors Universitaire Ziekenhuizen Leuven|University Hospital Antwerp|University Hospital Ghent|NETwerk Belgium October 7 2020 Phase 2|Phase 3
NCT04169321 Recruiting Drug: Single Arm Melanoma|Non-Small Cell Lung Cancer Cytosite Biopharma Inc.|Massachusetts General Hospital|University of Alabama at Birmingham|Chang Gung Memorial Hospital June 16 2020 Phase 1
NCT04168528 Recruiting Drug: 68GaNOTA-Anti-MMR-VHH2 Malignant Solid Tumor|Breast Cancer|Head and Neck Cancer|Melanoma (Skin) Universitair Ziekenhuis Brussel|Kom Op Tegen Kanker November 5 2019 Phase 1|Phase 2
NCT03924466 Recruiting Drug: 68GaNOTA-Anti-HER2 VHH1 Metastatic Breast Carcinoma|Locally Advanced Breast Cancer|Cancer of Pancreas|Solid Tumor With Intermediate or High HER2 Expression|Salivary Gland Cancer|Gastric Cancer|Endometrial Cancer|Uterine Cancer|Non Small Cell Lung Cancer|Biliary Tract Cancer|Cholangiocarcinoma|Colorectal Cancer|Urothelial Carcinoma|Prostate Cancer Universitair Ziekenhuis Brussel|Kom Op Tegen Kanker|Agentschap voor Innovatie door Wetenschap en Technologie Project Toegepast Biomedisch onderzoek met een primair Maatschappelijke finaliteit. April 1 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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