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NOTA Hydrotropic Agents chemical

Name: NOTA
Brand: Selleck Chemicals
SKU: S6923
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S6923

NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid is a bifunctional chelating agent which acts as the framework to construct PET imaging tools. It is also used for probe design and signal amplification via the multivalent effect and also has potential applications as diagnostic gallium radiopharmaceuticals.

Chemical Structure

Molecular Weight: 303.31

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Quality Control

Purity: >97%

Cited in Nature Medicine for its top-tier quality
COA
NMR
Datasheet
SDS

Related Targets	PROTAC Others Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Antibiotics for Plant Cell Culture
Other Hydrotropic Agents Products	PEG300 CMC-Na SBE-β-CD Tween 80 PEG400 Corn Oil Pluronic F-68 1-Methoxy PMS Castor oil

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (201.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 50 mg/mL

Ethanol : 2 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	303.31	Formula	C₁₂H₂₁N₃O₆	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	56491-86-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	OC(=O)CN1CCN(CCN(CC1)CC(O)=O)CC(O)=O

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/29697217/ [2] https://pubmed.ncbi.nlm.nih.gov/21740059/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06203587	Recruiting	Positron-Emission Tomography\|Colorectal Neoplasms	Huashan Hospital	December 1 2023	Not Applicable
NCT06203574	Recruiting	Positron-Emission Tomography\|Neoplasms	Huashan Hospital	December 1 2023	Not Applicable
NCT06203613	Recruiting	Positron Emission Tomography\|Pancreatic Neoplasms\|Igestive System Neoplasms	YiHui Guan\|Huashan Hospital	December 1 2023	Not Applicable
NCT06005116	Recruiting	Bladder Cancer	RenJi Hospital	September 15 2023	Not Applicable
NCT06165874	Recruiting	Non-small Cell Lung Cancer	Huashan Hospital	March 12 2023	Not Applicable

Tech Support

Handling Instructions

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