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NPD8733 p97 inhibitor

Name: NPD8733
Brand: Selleck Chemicals
SKU: S4453
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4453

NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.

Chemical Structure

Molecular Weight: 309.32

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S445301 DMSO]31 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.90%

98.90

Related Targets	E3 Ligase DUB Proteasome E1 Activating SUMO E2 conjugating
Related Products	NMS-873 DBeQ CB-5339 ML240

Chemical Information, Storage & Stability

Molecular Weight	309.32	Formula	C₁₈H₁₅NO₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	696655-62-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	COC1=CC=C(C=C1)C(=O)C2=C(NC(C)=O)C3=CC=CC=C3O2

Solubility

In vitro
Batch:

DMSO : 31 mg/mL (100.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	p97 ^[1]
In vitro	NPD8733 is identified as inhibiting the enhanced migration of fibroblasts when co-cultured with cancer cells, in which valosin-containing protein (VCP)/p97 is the target protein for this compound.^[2]
References	[1] https://pubmed.ncbi.nlm.nih.gov/30610116/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398144/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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