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Norgestrel ROS chemical

Cat.No.S5709

Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.
Norgestrel ROS chemical Chemical Structure

Chemical Structure

Molecular Weight: 312.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S570901 DMSO]62 mg/mL]false]Ethanol]21 mg/mL]false]Water]Insoluble]false Purity: 99.91%
99.91

Chemical Information, Storage & Stability

Molecular Weight 312.45 Formula

C21H28O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 6533-00-2 -- Storage of Stock Solutions

Synonyms WY-3707, SH-70850, SH-850, FH 122-A Smiles CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34

Solubility

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 21 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05896384 Recruiting
Healthy
Boehringer Ingelheim
 December 7 2023 Phase 1
NCT06048536 Completed
Contraception
Viatris Inc.
 December 22 2023 Phase 2
NCT04131517 Terminated
Healthy Female Participants
UCB Biopharma SRL|UCB Pharma
 October 23 2019 Phase 1
NCT03745144 Completed
Relapsing Multiple Sclerosis (RMS)
Merck KGaA Darmstadt Germany
 January 17 2019 Phase 1

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