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NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) Adenosine Receptor inhibitor

Name: NBMPR (S-(4-Nitrobenzyl)-6-thioinosine)
Brand: Selleck Chemicals
SKU: S0838
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0838

NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) is an inhibitor of ENT1 transporter that crosses the blood-brain barrier and is able to potentiate the neuroprotective effects of adenosine.

NBMPR (S-(4-Nitrobenzyl)-6-thioinosine) Adenosine Receptor inhibitor Chemical Structure

Quality Control

Batch: S083801 DMSO]84 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.81%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.81

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other Adenosine Receptor Inhibitors	Reversine CGS 21680 HCl ZM241385 SCH58261 Ciforadenant (CPI-444) A2AR antagonist 1 Etrumadenant (AB928) Imaradenant (AZD4635) DPCPX SCH-442416

Solubility

In vitro
Batch:

DMSO : 84 mg/mL (200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.100mg/ml (5.01mM)	Taking the 1 mL working solution as an example, add 50 μL of 42 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.700mg/ml (1.67mM)	Taking the 1 mL working solution as an example, add 50 μL of 14 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	419.41	Formula	C₁₇H₁₇N₅O₆S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	38048-32-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Nitrobenzylthioinosine, NBTI, NSC 296962			SMILES	C1=CC(=CC=C1CSC2=NC=NC3=C2N=CN3C4C(C(C(O4)CO)O)O)[N+](=O)[O-]

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	ENT1 transporter
References	[1] https://pubmed.ncbi.nlm.nih.gov/14633241/ [2] https://pubmed.ncbi.nlm.nih.gov/8971812/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-07)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07574099	ACTIVE_NOT_RECRUITING	Maxilla; Tooth Loss / Rehabilitation	University of Belgrade	2019-03-01
NCT05463133	RECRUITING	Chronic Granulomatous Disease	National Institute of Allergy and Infectious Diseases (NIAID)	2022-07-08	PHASE1; PHASE2
NCT07498257	ACTIVE_NOT_RECRUITING	Posttraumatic Stress Disorder (PTSD)	Medical University of South Carolina	2026-05-06
NCT07055087	NOT_YET_RECRUITING	Parkinson's Disease	University Hospital Tuebingen	2025-12	PHASE2
NCT07095608	RECRUITING	Oral Cancer; Squamous Cell Carcinoma	New York University	2025-09-01
NCT07581704	RECRUITING	Multiple Myeloma	Christopher Strouse	2026-06-01	PHASE1

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