Home Immunology & Inflammation AIM2 inhibitor NLRP3/AIM2-IN-3

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NLRP3/AIM2-IN-3 AIM2 inhibitor

Cat.No.E5801

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis. It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 μM. It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC, effectively preventing ASC oligomerization and blocking inflammasome assembly.
NLRP3/AIM2-IN-3 AIM2 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 266.30

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Chemical Information, Storage & Stability

Molecular Weight 266.30 Formula

C16H14N2O2

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CAS No. 1787787-60-3 Download SDF Storage of Stock Solutions

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