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Nafcillin Sodium

For research use only.

Catalog No.S4042 Synonyms: CL 8491

Nafcillin Sodium Chemical Structure

CAS No. 7177-50-6

Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 127 In stock
EUR 95 In stock
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Purity & Quality Control

Choose Selective β-lactamase Inhibitors

Biological Activity

Description Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.
β-lactamase [1]
33 mM(Kd)
In vitro

Nafcillin sodium inactivates β-lactamase through forming a covalent acyl-enzyme intermediate with β-lactamase via Ser-70. At concentrations above 80 mM, Nafcillin displays complete inhibition of β-lactamase within 200 s. Upon removal of the excess Nafcillin, the inhibited enzyme can be re-activated completely, with a rate constant of 2×10-3/s (25 ℃). [1] Nafcillin sodium is activity against penicillin-resistant staphylococci. The minimal concentration necessary for antistaphylococcic activity in vitro ranges from 0.2 μg/mL to 2 μg/mL. [2]


Solubility (25°C)

In vitro DMSO 91 mg/mL (200.23 mM)
Water 91 mg/mL (200.23 mM)
Ethanol 20 mg/mL (44.0 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 454.47


CAS No. 7177-50-6
Storage powder
in solvent
Synonyms CL 8491
Smiles CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID