Blog of Signaling Pathways

A simple protein histidine kinase activity assay for high-throughput inhibitor screening

72 views | Jan 16 2023

Donghee Lee et al. identified OSU-03012, a potent VanS HK inhibitor, which sensitized VRE toward vancomycin, highlighting the potential of AUDECY in HK inhibitor discovery. [Read the Full Post]

Combined femoral and acetabular version is sex-related and differs between patients with hip dysplasia and acetabular retroversion

23 views | Jan 16 2023

Malin K Meier et al. found that patients with DDH and AR had remarkable sex-related differences of FV and CV. [Read the Full Post]

Identifying the role of transient receptor potential channels (TRPs) in kidney renal clear cell carcinoma and their potential therapeutic significances using genomic and transcriptome analyses

71 views | Jan 15 2023

Jie Ren et al. provided useful insight that could aid and guide clinical practice and scientific research. [Read the Full Post]

A novel cell-based assay for the high-throughput screening of epithelial-mesenchymal transition inhibitors: Identification of approved and investigational drugs that inhibit epithelial-mesenchymal transition

49 views | Jan 15 2023

Hiroyuki Ishikawa et al. identified candidate drugs for EMT inhibition. [Read the Full Post]

Construction and validation of a cuproptosis-related lncRNA signature as a novel and robust prognostic model for colon adenocarcinoma

57 views | Jan 14 2023

Miaorong Xu et al. thought that a ten-cuproptosis-related lncRNA signature was constructed that provided promising insights into personalized prognosis and drug selection among COAD patients. [Read the Full Post]

Increased HRD score in cisplatin resistant penile cancer cells

55 views | Jan 14 2023

Ria Winkelmann et al. found that UKF-PEC-1rCDDP2500 did not display sensitivity to PARP inhibitors. [Read the Full Post]

ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice

30 views | Jan 13 2023

Ming Li et al. found that ATM might be a critical regulator of liver fibrosis progression. [Read the Full Post]

Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma

113 views | Jan 13 2023

Filippo Spriano et al. identified combinations that could improve the response to BET inhibitors in lymphomas. [Read the Full Post]

CRC Therapy Identifies Indian Hedgehog Signaling in Mouse Endometrial Epithelial Cells and Inhibition of Ihh-KLF9 as a Novel Strategy for Treating IUA

32 views | Jan 12 2023

Xinhao Zhou et al. suggested a promising application of hedgehog inhibitors as a targeted drug in the IUA clinic. [Read the Full Post]

IGF1R as a Potential Pharmacological Target in Allergic Asthma

63 views | Jan 12 2023

Elvira Alfaro-Arnedo et al. demonstrated that IGF1R could be considered a potential pharmacological target in murine HDM-induced asthma and a candidate biomarker in allergic asthma. [Read the Full Post]

GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells

37 views | Jan 11 2023

Jing Xia et al. suggested that BIO might be a promising therapeutic candidate for AML. [Read the Full Post]

The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease

42 views | Jan 11 2023

Annika Schulz et al. found that sFlt-1 only minimally affected the expression of stiffness-sensitive genes. [Read the Full Post]

Case report: olaparib use in metastatic lung adenocarcinoma with BRCA2 pathogenic variant

36 views | Jan 10 2023

Jonathan Soon Jian Hao et al. highlighted the utility of next-generation sequencing in identifying gene mutations. [Read the Full Post]

Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins

54 views | Jan 10 2023

Tianxiang Yi et al. suggested a novel combination therapeutic strategy for targeting p53 cancer in further clinical application. [Read the Full Post]

Systems Drug Design for Muscle Invasive Bladder Cancer and Advanced Bladder Cancer by Genome-Wide Microarray Data and Deep Learning Method with Drug Design Specifications

41 views | Jan 09 2023

Po-Wei Su et al. investigated the oncogenic mechanisms of MIBC and ABC, and provided promising therapeutic options for MIBC and ABC, respectively. [Read the Full Post]

Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization

34 views | Jan 09 2023

J J Patten et al. establishesd a rigorous approach for future pharmacological and computational identification of host factor dependencies and treatments for viral diseases. [Read the Full Post]

Guhong Injection Alleviates Cerebral Ischemia-Reperfusion Injury via the PKC/HIF-1α Pathway in Rats

86 views | Jan 08 2023

Li Yu et al. confirmed GHI could ameliorate cerebral I/R injury in MCAO rats possibly via the PKC/HIF-1α pathway. [Read the Full Post]

PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling

44 views | Jan 08 2023

Jodie Hay et al. demonstrated that PKCβ expression facilitates leukemogenesis and identified that BCR-mediated signalling was a key driver of CLL development in the PKCα-KR model. [Read the Full Post]

Identification of cuproptosis-related long non-coding ribonucleic acid signature as a novel prognosis model for colon cancer

61 views | Jan 07 2023

Rong Xu et al. found that inhibition of AL512306.3 and ZEB1-AS1 significantly suppressed the cell proliferation in colon cancer cells. [Read the Full Post]

A Novel Cuproptosis-Related Prognostic Model and the Hub Gene FDX1 Predict the Prognosis and Correlate with Immune Infiltration in Clear Cell Renal Cell Carcinoma

64 views | Jan 07 2023

Kenan Zhang et al. constructed a CRGs prognostic model and revealed that FDX1 could serve as a prognostic biomarker and predict therapeutic response in ccRCC. [Read the Full Post]