Blog of Signaling Pathways

Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers

41 views | Mar 30 2023

The results of the three phase 1 studies suggest that tirbanibulin 1% ointment is safe for topical application in the treatment of actinic keratosis, without any evidence of sensitization or phototoxic or photoallergic potential in healthy adults. [Read the Full Post]

Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability

48 views | Mar 30 2023

The study found that targeting the autocrine miR-483/IGF-2 stimulation and IGF-2 pathway may provide a viable treatment option for meningioma. [Read the Full Post]

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

99 views | Mar 30 2023

The study suggests that targeting the Hedgehog signaling pathway and cancer stem cells using inhibitors like AY9944 and GANT61 can improve the sensitivity of anti-cancer drug treatment in colorectal tumor patient-derived ALI organoids and may be a useful combinational therapeutic strategy against metastatic colorectal cancer. [Read the Full Post]

Towards personalized treatment with clozapine

117 views | Mar 30 2023

This study found that clozapine was more effective when used as a first- or second-line treatment, and identified factors associated with response to clozapine treatment and side effects, which could aid in the development of personalized treatment approaches for individuals with treatment-resistant schizophrenia. [Read the Full Post]

Identification of significant gene expression changes in multiple perturbation experiments using knockoffs

113 views | Mar 30 2023

The approach described uses the model-X knockoffs framework and Deep Neural Networks to identify significant gene expression changes in multiple perturbation experiments, allowing for better understanding of underlying mechanisms of disease and identification of new drug targets. [Read the Full Post]

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

21 views | Mar 29 2023

PDE10A may be a promising target for ovarian cancer chemoprevention and treatment, as its inhibition leads to decreased ovarian cancer cell growth and induces cell cycle arrest and apoptosis through PKA and PKG signaling and decreased activation of oncogenic and inflammatory signaling pathways. [Read the Full Post]

Transcriptomics-Based Phenotypic Screening Supports Drug Discovery in Human Glioblastoma Cells

33 views | Mar 29 2023

The study identifies novel druggable targets and potential combined drug, immunotherapy, and RNA vaccine approaches for treating glioblastoma, but effective pan-GBM drug treatment remains challenging due to extreme heterogeneity within drug-treated cells. [Read the Full Post]

Bicarbonate transporter SLC4A7 promotes EMT and metastasis of HNSCC by activating the PI3K/AKT/mTOR signaling pathway

87 views | Mar 29 2023

The study identifies SLC4A7 as a potential therapeutic target in HNSCC due to its promotion of EMT and metastasis through the PI3K/AKT/mTOR signaling pathway. [Read the Full Post]

Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells

51 views | Mar 29 2023

The study found that the dual PI3K/mTOR inhibitor GDC-0980 induces cytotoxicity and apoptosis in GBM cells and may be a potential candidate for anti-GBM therapy. [Read the Full Post]

Identification of Inhibitors of Tubulin Polymerization Using a CRISPR-Edited Cell Line with Endogenous Fluorescent Tagging of β-Tubulin and Histone H1

68 views | Mar 29 2023

The study presents a novel approach for identifying tubulin polymerization inhibitors using CRISPR-edited cells with fluorescently tagged endogenous β-tubulin and nuclear protein, enabling the screening of large compound libraries containing diverse chemical families for the discovery of new and effective therapies for cancer treatment. [Read the Full Post]

Acute Care Management of the HIV-Infected Patient: A Report from the HIV Practice and Research Network of the American College of Clinical Pharmacy

16 views | Mar 28 2023

This report provides guidance for clinicians managing HIV-infected patients and antiretroviral therapy in the inpatient setting, highlighting the need for a thorough medication history, consideration of drug-drug interactions and organ dysfunction, and timely follow-up to prevent medication errors and readmissions. [Read the Full Post]

Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis

50 views | Mar 28 2023

This study explores the role of circRNAs in hepatocellular carcinoma and identifies potential diagnostic and therapeutic targets using various analytical methods. [Read the Full Post]

The pro-inflammatory effect of triglyceride on human CD4+ T cells and experimental autoimmune uveitis

54 views | Mar 28 2023

Aberrant lipid metabolism, specifically increased triglyceride levels, stimulates CD4+ T cells and promotes Th1 and Th17 cell differentiation in the pathogenesis of autoimmune uveitis, and inhibition of TAG generation using A922500 can ameliorate the disease severity by down-regulating Th17 cell response and promoting apoptosis-related protein expression. [Read the Full Post]

The outcome of ibrutinib-based regimens in relapsed/refractory central nervous system lymphoma and the potential impact of genomic variants

47 views | Mar 28 2023

This study suggests that ibrutinib-based therapy is effective and safe for treating r/r CNSL patients, and patients with less genomic complexity, especially with regard to TMB, may benefit more from ibrutinib regimens. [Read the Full Post]

A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)

18 views | Mar 28 2023

The development and mechanism of action of CX-3543 and CX-5461, as well as their potential clinical application in cancer therapy, highlight the promising approach of synthetic lethality for identifying cancer patients who may benefit from G-quadruplex-targeting compounds. [Read the Full Post]

Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition

18 views | Mar 27 2023

This study identified a combination of small molecular inhibitors targeting the PI3K/AKT/MTOR and MAPK pathways that led to profound tumor cell destruction in 3D cultures of colorectal cancer cells. [Read the Full Post]

Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway

12 views | Mar 27 2023

The manuscript describes the development of a novel series of 1,2,3-triazole chalcone derivatives as potential agents against osteosarcoma, which demonstrated significant inhibitory activity against PI3K and mTOR kinases, as well as promising anti-cancer activity in vitro against several cancer cell lines including OS. [Read the Full Post]

Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids

121 views | Mar 27 2023

Human liver organoids derived from pluripotent stem cells have the potential to serve as a preclinical model for drug safety testing and anti-fibrotic drug screening. [Read the Full Post]

Investigation of the Pharmacokinetics and Metabolic Fate of Fasiglifam (TAK-875) in Male and Female Rats Following Oral and Intravenous Administration

96 views | Mar 27 2023

Fasiglifam has good oral bioavailability and is extensively metabolized in rats, with a novel biotransformation observed and sex-related differences in drug elimination. [Read the Full Post]

Iatrogenic Cushing's Syndrome: The Result of Cobicistat and Glucocorticoid Interaction in an HIV Patient After Bariatric Surgery

31 views | Mar 27 2023

The case report describes a patient with HIV-hepatitis C virus co-infection who developed iatrogenic Cushing's syndrome due to an interaction between cobicistat-boosted darunavir and inhaled corticosteroids after undergoing sleeve gastrectomy for morbid obesity. [Read the Full Post]