Blog of Signaling Pathways

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

58 views | Nov 01 2023

Inhibition of IRE1α in triple negative breast cancer cells leads to DGAT2-dependent accumulation of triacylglycerols (TAGs) and sensitizes the cells to nutritional stress, highlighting the importance of IRE1α RIDD activity in reprogramming cellular lipid metabolism. [Read the Full Post]

Gram-Scale Preparation of Cannflavin A from Hemp ( Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase

28 views | Nov 01 2023

Cannflavin A (CFA), a compound derived from Cannabis sativa, has been shown to effectively inhibit kynurenine-3-monooxygenase (KMO), an enzyme in the neurotoxic kynurenine pathway (KP), indicating its potential as a therapeutic agent for neuroinflammatory and neurodegenerative disorders related to KP metabolites. [Read the Full Post]

Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates

0 views | Nov 01 2023

The study demonstrated that the combination of the MET inhibitor merestinib with the FGFR inhibitor LY2874455 showed preliminary safety and biological activity, indicating the potential of targeting MET and FGFR pathways in the treatment of relapsed/refractory acute myeloid leukemia. [Read the Full Post]

Developments and challenges of FLT3 inhibitors in acute myeloid leukemia

35 views | Oct 31 2023

FLT3 mutations are common in acute myeloid leukemia (AML) and targeting FLT3 has become a crucial part of AML treatment, although resistance to FLT3 inhibitors remains a challenge that is being addressed through the development of novel agents and multitarget strategies. [Read the Full Post]

The regeneration-responsive element careg monitors activation of Müller glia after MNU-induced damage of photoreceptors in the zebrafish retina

13 views | Oct 31 2023

Zebrafish can regenerate damaged photoreceptors, and a study identified that the careg reporter gene marks activated Müller glia cells involved in regeneration, revealing distinct molecular signatures and the involvement of TOR signaling in the regenerative process. [Read the Full Post]

Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

24 views | Oct 31 2023

This study developed an in vitro cellular model and identified inhibitors, CK869 and EIPA, that effectively reduced ACE2 expression and inhibited ACE2-dependent viral entry, providing potential candidates for further investigation as therapeutic drugs against COVID-19. [Read the Full Post]

MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

25 views | Oct 31 2023

MK-8719, a selective O-GlcNAcase inhibitor, shows promise in elevating O-GlcNAc levels, reducing pathologic tau, and mitigating brain atrophy, suggesting its potential as a therapeutic approach for Alzheimer's disease and other tauopathies. [Read the Full Post]

Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway

60 views | Oct 31 2023

This study demonstrates that IGFBP3 regulates the mineralization microenvironment during tooth development through its modulation of the DKK1-Wnt/beta-catenin axis, highlighting its potential importance in tooth regeneration and dental care. [Read the Full Post]

Assessment of alterations in histone modification function and guidance for death risk prediction in cervical cancer patients

0 views | Oct 30 2023

The study comprehensively evaluated histone modification status in cervical cancer patients, identifying a novel HMAG signature of nine histone modification-associated genes with strong prognostic value, offering crucial insights into prognosis prediction and tailored clinical treatments. [Read the Full Post]

Role of P2X7R in eosinophilic and non‑eosinophilic chronic rhinosinusitis with nasal polyps

60 views | Oct 30 2023

The study found that P2X7R is overexpressed in chronic rhinosinusitis with nasal polyps (CRSwNP), and its activation mediates NLRP3 inflammasome activation, suggesting its potential role in the pathogenesis of CRSwNP. [Read the Full Post]

CX3CL1 in the red bone marrow promotes renal cell carcinoma to metastasize to the spine by involving the Src-related pathway

49 views | Oct 30 2023

CX3CL1 promotes migration and invasion of renal cell carcinoma (RCC) cells, potentially facilitating RCC metastasis to the spine, through activation of the Src/FAK signaling pathway. [Read the Full Post]

[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling

15 views | Oct 30 2023

[6]-Gingerol ([6]-GIN) induces apoptosis in bladder cancer cells, inhibiting cell proliferation, disrupting mitochondrial function, regulating key proteins and enzymes involved in cell survival and death, activating MAPKs, and increasing reactive oxygen species, suggesting its potential as a promising candidate for the development of bladder cancer treatment. [Read the Full Post]

Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

18 views | Oct 30 2023

The combination of the dual inhibitor BEZ235 and Lactobacillus rhamnosus HN001, along with its metabolic product propionic acid (PA), demonstrates a novel and efficient therapeutic strategy for prolonging cardiac transplant survival by suppressing the PI3K/AKT/mTOR pathway, rescuing intestinal microbiota imbalance, and enriching regulatory T cells. [Read the Full Post]

Iron overload due to SLC40A1 mutation of type 4 hereditary hemochromatosis

66 views | Oct 30 2023

The reported case of hereditary hemochromatosis type 4B involving a SLC40A1 gene mutation was effectively treated with monthly red blood cell apheresis followed by oral deferasirox therapy. [Read the Full Post]

Identification of novel inhibitors for trigger factor (TF) of M. tb: an in silico investigation

43 views | Oct 29 2023

A computational model of the Mycobacterium tuberculosis trigger factor protein was developed and two potential inhibitors, HTS02984 and S06856, were identified through virtual screening, offering potential avenues for the development of tuberculosis therapies. [Read the Full Post]

BTBBCL6 dimers as building blocks for reversible drug-induced protein oligomerization

94 views | Oct 29 2023

This study characterized the BTB domain of the transcription factor BCL6 as a small-molecule-controlled, reversible oligomerization switch, enabling precise control over protein function and demonstrating its potential for synthetic biology applications. [Read the Full Post]

Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy

38 views | Oct 29 2023

An injectable tumor lysates-constructed hydrogel has been developed to address the challenges of T cell-based immunotherapy, providing a robust antigen reservoir, preventing T cell exhaustion, and suppressing immune evasion, thereby enhancing the effectiveness of tumor treatment. [Read the Full Post]

Inhibition of histone deacetylases attenuates tumor progression and improves immunotherapy in breast cancer

60 views | Oct 29 2023

HDAC inhibitors in breast cancer have demonstrated potent anti-tumor activity and the potential to improve immunotherapy outcomes, highlighting their potential as potent agents to enhance breast cancer treatment. [Read the Full Post]

Identification of Tau-Tubulin Kinase 1 Inhibitors by Microfluidics-based Mobility Shift Assay from a Kinase Inhibitor Library

74 views | Oct 29 2023

This study identified a peptide substrate for human TTBK1 and developed a microfluidics-based assay, enabling the screening of kinase inhibitors and the potential development of novel hTTBK1 inhibitors for Alzheimer's disease prevention. [Read the Full Post]

Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation

44 views | Oct 28 2023

Inhibition of STAT5 using STAT5-IN-1 effectively reduces cardiac hypertrophy in Ang II-induced mice by decreasing inflammation, suggesting a potential therapeutic strategy for mitigating hypertrophy. [Read the Full Post]