Blog of Signaling Pathways

Chemotherapy-Resistant Breast Cancer and Carcinomatous Pleuritis Successfully Treated with Abemaciclib plus Letrozole Therapy

42 views | May 05 2023

This case report describes a chemotherapy-resistant case of invasive micropapillary carcinoma in an older adult patient that was effectively treated with abemaciclib plus letrozole therapy. [Read the Full Post]

Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors

37 views | May 05 2023

This study used an in silico approach to identify potential small molecule inhibitors of the Ebola virus by targeting the N-terminal domain of VP40, resulting in the identification of several natural-product-derived compounds and approved drugs with potential anti-EBOV activity that can be further explored for EVD treatment. [Read the Full Post]

Molecular Design of 68Ga- and 89Zr-Labeled Anticalin Radioligands for PET-Imaging of PSMA-Positive Tumors

62 views | May 05 2023

The study demonstrates the potential of Anticalin proteins as radioligands for PET-imaging of xenograft tumors in mice, with the use of PASylation technology to tailor their plasma half-life and the cyclic radiochelator FsC being superior to Dfo for 89Zr-ImmunoPET-imaging. [Read the Full Post]

Quality by Design (QbD)-Steered Development and Validation of Analytical and Bioanalytical Methods for Raloxifene: Application of Monte Carlo Simulations and Variance Inflation Factor

68 views | May 05 2023

The study developed and validated a sensitive, rapid, reproducible, and economical HPLC method for quantifying raloxifene hydrochloride using QbD principles, and demonstrated its applicability for drug quantification in biological fluids, as well as in bulk and marketed dosage forms. [Read the Full Post]

Nitric Oxide Precursors and Dimethylarginines as Risk Markers for Accelerated Measured GFR Decline in the General Population

86 views | May 05 2023

This prospective cohort study found that higher levels of asymmetric dimethylarginine were associated with a slower decline in glomerular filtration rate, while higher levels of citrulline and ornithine were associated with accelerated GFR decline and an increased risk of new-onset chronic kidney disease, suggesting a significant role of NO metabolism in the pathogenesis of CKD in middle-aged people. [Read the Full Post]

Potential drug candidates as P-glycoprotein inhibitors to reverse multidrug resistance in cancer: an in silico drug discovery study

28 views | May 04 2023

This study aimed to identify potential P-glycoprotein inhibitors for the treatment of carcinoma using in silico techniques, and identified five promising drug candidates with high binding energies and good pharmacokinetic properties. [Read the Full Post]

Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data

77 views | May 04 2023

The study investigated whether the pharmacodynamic properties of cariprazine fit into a previously developed model for the treatment of bipolar depression, which was based on a combination of clinical and preclinical data, and found that its properties fit well with the proposed model, but further clarification is needed regarding its norepinephrine reuptake inhibition. [Read the Full Post]

Long-term follow-up of HCV-infected patients with end-stage chronic kidney disease after sustained virological response with direct-acting antiviral therapy

48 views | May 04 2023

The study found that although HCV cure may play a positive role in renal function in CKD stage 3b-4, long-term mortality remained high among end-stage CKD patients, with no improvement in renal function observed and a high proportion of patients requiring kidney transplantation. [Read the Full Post]

Effects of Ertugliflozin on Kidney Outcomes in Patients With Heart Failure at Baseline in the Evaluation of Ertugliflozin Efficacy and Safety Cardiovascular Outcomes (VERTIS CV) Trial

37 views | May 04 2023

The post hoc analysis of the VERTIS CV trial found that the beneficial effects of ertugliflozin on kidney outcomes were not affected by baseline heart failure status in patients with type 2 diabetes mellitus and atherosclerotic cardiovascular disease. [Read the Full Post]

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV

45 views | May 04 2023

This study conducted a systematic review of the literature on second-line treatments for drug-resistant strains of herpes simplex viruses, and found that there are potential options that could effectively manage these infections. [Read the Full Post]

Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1

27 views | May 03 2023

The discovery that dasabuvir, an FDA-approved drug for HCV treatment, acts as a ROCK1 inhibitor and suppresses ESCC growth through blocking ROCK1/ERK signaling pathway provides a promising candidate for further investigation as an anti-cancer therapy for ESCC. [Read the Full Post]

Structural and functional characterization of RNA dependent RNA polymerase of Macrobrachium rosenbergii nodavirus (MnRdRp)

34 views | May 03 2023

The study provides insights into the structure and potential drug targeting of MnRdRp, the RNA-dependent RNA polymerase of the MrNV virus that causes white tail disease in farmed Macrobrachium rosenbergii. [Read the Full Post]

The effect of different direct antivirals on hepatic steatosis in nondiabetic and naïve hepatitis C-infected Egyptian patients

35 views | May 03 2023

This study found that achieving sustained virological response after 12 weeks of treatment with direct antiviral drugs improved the metabolic profile and reduced hepatic steatosis and fibrosis in nondiabetic, chronically infected HCV Egyptian patients naive to any form of HCV treatment, but was also associated with an increase in LDL mostly due to viral-host molecular interaction. [Read the Full Post]

Efficacy and safety of ombitasvir/paritaprevir/ritonavir-based therapy in HCV patients with chronic kidney disease

38 views | May 03 2023

The study showed that ombitasvir/paritaprevir/ritonavir-based therapy is highly effective and safe in chronic HCV patients with CKD, with the highest SVR achieved with ombitasvir/paritaprevir/ritonavir plus ribavirin. [Read the Full Post]

Assessment of alteration in antiviral plasma concentration across dialysis days: computational and analytical study

35 views | May 03 2023

This study found that protein-bound uremic toxins have a lower binding affinity than directly acting antivirals, indicating a reduced liability of competitive displacement and suggesting that PBUT accumulation may have limited effect on the disposition of DAAs. [Read the Full Post]

Apatinib combined with SOX regimen for conversion therapy in advanced gastric cancer patients: a retrospective cohort study

76 views | May 02 2023

The study shows that conversion chemotherapy followed by surgery and apatinib-targeted therapy combined with SOX chemotherapy may be beneficial for patients with advanced gastric cancer. [Read the Full Post]

High level expression of nicotinamide nucleoside kinase from Saccharomyces cerevisiae and its purification and immobilization by one-step method

25 views | May 02 2023

This study optimized the expression and immobilization of ScNRK1 to improve the enzyme activity and stability for the enzymatic synthesis of NMN, which has important implications for human health and potential applications in commercial production. [Read the Full Post]

Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans

19 views | May 02 2023

The study identified Lactobacillus plantarum strains that produce urolithin A and found that fermented pomegranate juice extracts from these strains can extend lifespan in C. elegans by improving mitochondrial function and/or reducing reactive oxygen species levels, highlighting the potential for developing anti-aging products. [Read the Full Post]

Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC-MS/MS

21 views | May 02 2023

The study developed and validated an HPLC-MS/MS method for determining UK-5099 levels in mice plasma after intraperitoneal administration, and reported the pharmacokinetic parameters of UK-5099 in mice, which will aid further study of its administration in animals and humans. [Read the Full Post]

Anti-Parkinson Effects of Holothuria leucospilota-Derived Palmitic Acid in Caenorhabditis elegans Model of Parkinson's Disease

32 views | May 02 2023

The study found that HLEA-P3, a compound derived from the sea cucumber Holothuria leucospilota, composed of palmitic acid, showed potential anti-Parkinson effects in C. elegans models by restoring dopaminergic neurons, reducing oxidative stress, decreasing α-synuclein aggregation, and upregulating genes encoding antioxidant enzymes and autophagic mediators. [Read the Full Post]