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MicroRNA-26b regulates BMSC osteogenic differentiation of TMJ subchondral bone through β-catenin in osteoarthritis

41 views | Jul 10 2022

Jinlu Yang et al. thought that miR-26b might modulate subchondral bone loss induced by abnormal occlusion and influence the osteogenic differentiation of subchondral BMSCs through β-catenin in the context of TMJ-OA progression. [Read the Full Post]

RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface

65 views | Jun 07 2022

A-Ri Cho et al. demonstrated that RNF43 frameshift mutations retained normal functionality; thus, targeted anti-cancer therapy could be developed according to the mutation type of RNF43. [Read the Full Post]

Wnt-C59 inhibits proinflammatory cytokine expression by reducing the interaction between β-catenin and NF-κB in LPS-stimulated epithelial and macrophage cells

695 views | Aug 17 2021

Jaewoong Jang et al. suggested that the anti-inflammatory effect of Wnt-C59 was mediated by the reduction of the cellular level of β-catenin and the interaction between β-catenin and NF-κB. [Read the Full Post]

Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB

308 views | Aug 16 2021

Jaewoong Jang et al. thought that Wnt-C59 might be useful for the suppression of the multiple-organ dysfunction during sepsis. [Read the Full Post]