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CDK

Successful treatment with steroid pulse therapy for a COVID-19 case with progressive respiratory failure during treatment for pleural metastasis of breast cancer

6 views | May 18 2022

Hikari Jimbo et al. thought that a critical element in cases such as this one was that treatment decisions were made by a team of specialists, including pulmonologists. [Read the Full Post]

Efficacy of sirolimus in children with lymphatic malformations of the head and neck

16 views | May 09 2022

S Wiegand 1 et al. found that sirolimus could be an effective treatment for children with large complicated lymphatic malformations of the head and neck. [Read the Full Post]

Novel immune-related signature based on immune cells for predicting prognosis and immunotherapy response in clear cell renal cell carcinoma

30 views | Apr 21 2022

Libin Zhou et al.defined a robust signature that might be promising for predicting clinical outcomes and immunotherapy and targeted therapy response in ccRCC patients. [Read the Full Post]

Partial response to dabrafenib and trametinib in relapsed BRAF V600E-Mutated multiple myeloma and possible mechanisms of resistance

35 views | Apr 18 2022

Tina Ernst et al. described a very good partial response and possible mechanisms of resistance to a combination of the BRAF inhibitor dabrafenib. [Read the Full Post]

Multiple myeloma: Combination therapy of BET proteolysis targeting chimeric molecule with CDK9 inhibitor

0 views | Apr 14 2022

Su-Lin Lim et al. found that the combination of a BET PROTAC (ARV 825) plus AZD 4573 (CDK9 inhibitor) was effective against MM cells. [Read the Full Post]

Inhibition of CDK9 attenuates atherosclerosis by inhibiting inflammation and phenotypic switching of vascular smooth muscle cells

36 views | Apr 04 2022

Shushi Huang et al. found that inhibition of CDK9 might be a novel therapeutic target for the prevention of atherosclerosis. [Read the Full Post]

Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells

72 views | Mar 29 2022

Liling Jiang et al. provided pre-clinical evidence for application of targeting the CDK7/9 in DLBCL. [Read the Full Post]

A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

0 views | Mar 14 2022

Chiara Ghezzi et al. thought that CDK7 was a key regulator of glucose consumption in cells with an activated PI3K pathway. [Read the Full Post]

The role of drug efflux and uptake transporters ABCB1 (P-gp), ABCG2 (BCRP) and OATP1A/1B and of CYP3A4 in the pharmacokinetics of the CDK inhibitor milciclib

62 views | Mar 14 2022

Alejandra Martínez-Chávez et al. found that the low impact of OATP1 and CYP3A could be clinically favorable for milciclib, reducing the risks of unintended drug-drug interactions or interindividual variation in CYP3A4 activity. [Read the Full Post]

Drug repositioning based on gene expression data for human HER2-positive breast cancer

175 views | Jan 21 2022

Farkhondeh Khanjani et al. suggested that some repurposed drugs based on gene expression data could be noticed as potential drugs for the treatment of HER2-positive breast cancer. [Read the Full Post]