Blog of Signaling Pathways

In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling

38 views | Mar 02 2023

A novel cell-free in vitro setup was developed and tested to evaluate the dynamic dissolution, bio-conversion, and permeation of fosamprenavir, showing promising results for gaining a deeper understanding of the bioconversion and permeation of phosphate-ester prodrugs. [Read the Full Post]

Evaluation of the knowledge of hematologists about the management of infectious complications in hematologic patients

61 views | Mar 02 2023

The study results highlight the need for continuous education for hematologists in Brazil to improve their knowledge and understanding of infectious complications in patients with hematologic malignancies and hematopoietic cell transplant recipients. [Read the Full Post]

Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH

83 views | Mar 02 2023

The study found a positive correlation between the expression of MXRA7 and acute B-ALL and suggests that knockdown of MXRA7 may be a potential target for the treatment of B-ALL by reducing cell proliferation and increasing sensitivity to cytarabine, but further research is needed to confirm its usefulness. [Read the Full Post]

13-cis-retinoic acid (NSC 122758) in the treatment of children with metastatic neuroblastoma unresponsive to conventional chemotherapy: report from the Childrens Cancer Study Group

113 views | Mar 02 2023

The study conducted by the Children's Cancer Study Group on 13-cis-retinoic acid in children with advanced neuroblastoma showed no significant activity and the drug was not effective in treating the condition. [Read the Full Post]

CNKSR2, a downstream mediator of retinoic acid signaling, modulates the Ras/Raf/MEK pathway to regulate patterning and invagination of the chick forebrain roof plate

49 views | Mar 02 2023

The study found that CNKSR2, a novel mediator of retinoic acid (RA) signaling, plays a crucial role in the morphogenesis of the avian forebrain by modulating the Ras/Raf/MEK signaling, leading to proper invagination, cell proliferation, and patterning of the roof plate for the formation of the cerebral hemispheres. [Read the Full Post]

The Gradual Release of Alendronate for the Treatment of Critical Bone Defects in Osteoporotic and Control Rats

28 views | Mar 01 2023

This study demonstrates the potential of emulsion/dispersion scaffolds containing ALN and HA nanoparticles for local delivery of ALN in the treatment of osteoporosis, with positive effects on bone formation observed both in vitro and in vivo. [Read the Full Post]

The successful treatment of Enterocytozoon bieneusi Microsporidiosis with nitazoxanide in a patient with B-ALL: A Case Report

53 views | Mar 01 2023

This case highlights the need to consider opportunistic infections in immunocompromised patients and the importance of using metagenomic sequencing in diagnosing such infections, as well as the limited available options for treating E. bieneusi infections and the need for further research. [Read the Full Post]

Addition of Nitazoxanide to Standard Clarithromycin Based Triple Therapy for 2 Weeks Effectively Eradicates Treatment-Naive Helicobacter Pylori Infection. A Single Centre prospective, open-label study

93 views | Mar 01 2023

The NACE regimen (nitazoxanide, amoxicillin, clarithromycin, and esomeprazole) was found to be an effective and well-tolerated treatment for H. pylori infection, resulting in eradication in over 90% of patients in both per-protocol and intention to treat analyses. [Read the Full Post]

Exploring drug repositioning for leishmaniasis treatment: Ivermectin plus polymeric micelles induce immunological response and protection against tegumentary leishmaniasis

34 views | Mar 01 2023

The study found that ivermectin has the potential to be a candidate for the treatment of leishmaniasis caused by different species of Leishmania, as it showed efficacy in reducing parasite load and lesion size in infected mice, with low toxicity, and maintained efficacy 30 days after therapy. [Read the Full Post]

Understanding the impact of halogen functional group (Br, Cl, F, OH) in amprenavir ligand of the HIV protease

94 views | Mar 01 2023

Study provides valuable insights into the structure-activity relationship of protein-ligand interactions in HIV/AIDS research and highlights the importance of halogen and hydrogen bond interactions in the development of new antiviral drugs. [Read the Full Post]

Understanding drug resistance patterns across different classes of antiretrovirals used in HIV-1-infected treatment-Naïve and experienced patients in Mumbai, India

43 views | Feb 28 2023

The study found that treatment-experienced patients had higher incidence of high-level resistance to antiretroviral drugs compared to treatment-naive patients, with a positive correlation observed for within class resistance across antiretrovirals, and highlights the importance of genotypic drug resistance testing before starting treatment. [Read the Full Post]

Traditional and disease-related cardiovascular risk factors in ANCA-associated vasculitis: a prospective, two-centre cohort study

56 views | Feb 28 2023

The study found that age, Framingham risk score, HbA1c level, Diabetes Mellitus (DM), and previous cardiovascular event were significantly associated with cardiovascular events in patients with ANCA-associated vasculitis, highlighting the importance of treating risk factors for optimal long-term outcomes. [Read the Full Post]

Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors

32 views | Feb 28 2023

The study compared two chemotherapy regimens in treating recurrent central nervous system tumors in 73 pediatric patients, with the more toxic MOPP producing more responses but not statistically significant differences in duration of response or survival, and with two patients in the MOPP group experiencing fatal myelosuppression. [Read the Full Post]

Excess copper catalyzes protein disulfide bond formation in the bacterial periplasm but not in the cytoplasm

76 views | Feb 28 2023

Copper toxicity was found to impact proteins by generating disulfide bonds in the periplasm and inactivating enzymes with solvent-exposed [4Fe-4S] clusters, but it was too inefficient at creating disulfide stress in the cytoplasm due to a slow rate of oxygen regeneration. [Read the Full Post]

High Glucose-Induced Kidney Injury via Activation of Necroptosis in Diabetic Kidney Disease

101 views | Feb 28 2023

The study found that inhibiting the RIPK1/RIPK3/MLKL pathway through the use of necrostatin-1 or N-acetylcysteine can effectively protect the kidney against high glucose-induced damage in diabetic mice and could be a therapeutic target for diabetic kidney disease. [Read the Full Post]

Cost-effectiveness of targeted screening for non-valvular atrial fibrillation in the United Kingdom in older patients using digital approaches

71 views | Feb 27 2023

Screening for non-valvular atrial fibrillation in patients aged 75 or older in the UK is cost-effective and potentially cost-saving, with handheld digital devices such as Zenicor, pulse palpation, and KardiaMobile, and targeted screening predictive algorithms found to be the dominant options compared to no screening. [Read the Full Post]

DOAC compared with warfarin for VTE in patients with obesity: a retrospective cohort study conducted through the VENUS network

37 views | Feb 27 2023

The study found that DOACs were not inferior to warfarin in terms of VTE recurrence in obese patients and were associated with a lower major bleeding rate. [Read the Full Post]

LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways

56 views | Feb 27 2023

The study found that LY450139 has the potential to prevent the failure of joint implants by inhibiting the formation of osteoclasts, which break down bone, through the inhibition of the NF-κB and Notch signaling pathways. [Read the Full Post]

A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion

91 views | Feb 27 2023

This is a case report of the first instance of Mycobacterium aubagnense being isolated from ascites in a patient with severe peritoneal effusion, highlighting the need for further research to determine the clinical significance of the infection and effective treatment strategies. [Read the Full Post]

Predictors of Poor Very Early Diuretic Response and Effectiveness of Early Tolvaptan in Symptomatic Acute Heart Failure

30 views | Feb 27 2023

Early administration of tolvaptan (TLV) in patients with acute decompensated heart failure (ADHF) who have a predicted poor diuretic response (DR) can improve DR and reduce the risk of worsening renal function, according to a multicenter retrospective study. [Read the Full Post]