cGAS

African swine fever virus pS273R antagonizes stress granule formation by cleaving the nucleating protein G3BP1 to facilitate viral replication

28 views | Sep 30 2023

The study reveals that African swine fever virus (ASFV) inhibits the formation of cytoplasmic stress granules (SGs) by cleaving the G3BP1 protein, thereby evading host stress and innate antiviral responses. [Read the Full Post]

Development of a High-Throughput Urosepsis Mouse Model

76 views | Sep 11 2023

This study developed a reproducible murine model of slow-paced, monomicrobial urosepsis originating from the urinary tract, allowing for the investigation of prolonged urosepsis and providing insights into associated biomarkers and immune responses. [Read the Full Post]

IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity

68 views | Jun 09 2023

This study investigates the role of IL-33/ST2 signaling in regulating APAP-induced STING signaling and suggests that inhibiting cGAS/STING may be a potential therapy for AILI. [Read the Full Post]