Blog of Signaling Pathways

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

39 views | Mar 22 2023

The study found that fisetin treatment was effective in mitigating the reproductive damage caused by arsenic exposure in male albino rats, indicating its potential as a therapeutic candidate against arsenic-generated male reproductive toxicity. [Read the Full Post]

Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process

115 views | Mar 22 2023

The study evaluated the anti-inflammatory effect of topical Dipotassium Glycyrrhizinate (DPG) on the healing of cutaneous wounds by secondary intention in an in vivo experimental model and found that DPG promotes skin wound healing through modulation of distinct mechanisms and signaling pathways, including anti-inflammatory ones. [Read the Full Post]

Neurotherapeutic Effects of Quercetin and Its Metabolite Compounds on Cognitive Impairment and Parkinson's Disease: An In Silico Study

141 views | Mar 22 2023

This study identified the metabolomic profile and potential therapeutic effects of quercetin and its metabolites in cognitive impairment and Parkinson's disease, but further research is needed to confirm these findings in vivo and address potential adverse effects. [Read the Full Post]

Managing Vibration Training Safety by Using Knee Flexion Angle and Rating Perceived Exertion

120 views | Mar 22 2023

This study found that a knee flexion angle of approximately 110 degrees is most effective in reducing vibration transmissibility during whole-body vibration exercise, while also observing a positive correlation between the rating of perceived exertion and the platform-to-head transmissibility. [Read the Full Post]

Mechanisms of paeoniaceae action as an antidepressant

44 views | Mar 22 2023

Paeoniflorin (PF) has been shown to have multiple mechanisms through which it exerts its antidepressant effects, including increasing the levels of monoamine neurotransmitters, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of BDNF. [Read the Full Post]

Abigene, a Prospective, Multicentric Study of Abiraterone Acetate Pharmacogenetics in Metastatic Castration-Resistant Prostate Cancer

47 views | Mar 21 2023

This study suggests that genetic variations in CYP17A1 and other androgen-related genes may help predict the efficacy and toxicity of abiraterone acetate treatment in advanced prostate cancer patients. [Read the Full Post]

Development and Optimisation of Inhalable EGCG Nano-Liposomes as a Potential Treatment for Pulmonary Arterial Hypertension by Implementation of the Design of Experiments Approach

88 views | Mar 21 2023

The research developed an inhalable EGCG nano-liposome formulation with desirable properties and demonstrated its potential effectiveness in treating PAH by inhibiting the TGFβ pathway. [Read the Full Post]

Unusual Square Pyramidal Chalcogenide Mo5 Cluster with Bridging Pyrazolate-Ligands

24 views | Mar 21 2023

New chalcogenide molybdenum clusters with square pyramidal complexes [{Mo5(μ3-Se)i4(μ4-Se)i(μ-pz)i4}(pzH)t5]1+/2+ have been synthesized and characterized, showing promise for use in superconducting, magnetic, and catalytic systems. [Read the Full Post]

Metabolomic Analysis Reveals the Metabolic Diversity of Wild and Cultivated Stellaria Radix ( Stellaria dichotoma L. var. lanceolata Bge.)

107 views | Mar 21 2023

The study compared the metabolites of wild and cultivated Yinchaihu, showing that the contents of total sterols and total flavonoids were significantly higher in wild Yinchaihu, while identifying 97 significant differences in metabolites between the two sources. [Read the Full Post]

Dihydroartemisinin-ursodeoxycholic acid conjugate is a potential treatment agent for inflammatory bowel disease

66 views | Mar 21 2023

Compound 4, a dihydroartemisinin-ursodeoxycholic acid conjugate, exhibits strong immunosuppressive activity and has the potential to be developed into an anti-inflammatory bowel disease drug. [Read the Full Post]

Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling

67 views | Mar 20 2023

This study found that selective inhibition of histone deacetylase 6 (HDAC6) can enhance the radiosensitivity of bladder cancer cells and suppress radiation-induced oncogenic signaling, suggesting its potential as a therapeutic strategy in combination with radiation therapy. [Read the Full Post]

WP1130 relieves septic shock in mice by inhibiting NLRP3 inflammasome activation

57 views | Mar 20 2023

WP1130 specifically inhibits NLRP3 inflammasome activation and alleviates septic shock in mice. [Read the Full Post]

USP9x promotes CD8 + T-cell dysfunction in association with autophagy inhibition in septic liver injury

67 views | Mar 20 2023

This study suggests that USP9x inhibition could be a potential therapeutic target for septic liver injury by promoting CD8+ T-cell function via autophagy regulation. [Read the Full Post]

Delayed aortic regurgitation after TEVAR procedure: a case report

75 views | Mar 20 2023

This case report underscores the importance of careful attention and technique when performing catheter-related procedures around the aortic valve to prevent delayed aortic insufficiency. [Read the Full Post]

Prospective role of 3βHSD1 in prostate cancer precision medicine

59 views | Mar 20 2023

3βHSD1 is both a promising therapeutic target and a predictive biomarker for prostate cancer, with the development of novel inhibitors and a better understanding of its regulatory mechanisms providing new opportunities for disease management. [Read the Full Post]

Defining the role of mTOR pathway in the regulation of stem cells of glioblastoma

51 views | Mar 19 2023

Inhibition of the mTOR pathway, particularly with the small molecule inhibitor Torin2, shows potential as a strategy for targeting the cancer stem cells of glioblastoma, a deadly brain tumor characterized by resistance to conventional therapies. [Read the Full Post]

Bioinformatics and network-based screening and discovery of potential molecular targets and small molecular drugs for breast cancer

0 views | Mar 19 2023

This study used bioinformatics and network-based approaches to identify key genes and small molecular drugs that could be effective in the diagnosis, prognosis, and treatment of breast cancer. [Read the Full Post]

PI3Kδ inhibition potentiates glucocorticoids in B-ALL by decreased receptor phosphorylation and enhanced gene regulation

67 views | Mar 19 2023

The research shows that combining a PI3Kδ inhibitor with glucocorticoids enhances the effectiveness of glucocorticoid therapy in B-lymphoblastic leukemia by decreasing inhibitory GR phosphorylation and enhancing downstream gene regulation. [Read the Full Post]

Catastrophic antiphospholipid syndrome in lupus-associated immune thrombocytopenia treated with eltrombopag A case series and literature review

86 views | Mar 19 2023

The reported cases suggest a possible association between eltrombopag treatment for refractory ITP and the development of catastrophic antiphospholipid syndrome in SLE patients with concurrent triple positive APLA. [Read the Full Post]

Eltrombopag Inhibits Metastasis in Breast Carcinoma by Targeting HuR Protein

45 views | Mar 19 2023

The study found that eltrombopag inhibits breast cancer metastasis by targeting HuR protein and suppressing the expressions of several cancer metastasis-related genes. [Read the Full Post]