Blog of Signaling Pathways

Effect of 11-Deoxycorticosterone in the Transcriptomic Response to Stress in Rainbow Trout Skeletal Muscle

43 views | Mar 26 2023

The study demonstrates the role of 11-deoxycorticosterone (DOC) in modulating the stress response of skeletal muscles in rainbow trout and highlights its differential modulation by glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), complementing the action of cortisol. [Read the Full Post]

A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

53 views | Mar 26 2023

The proposed chemotactic nanomotor loaded with brain endothelial cell targeting agent angiopep-2 and anti-tumor drug TLND, which uses ROS/iNOS as chemoattractants to induce the chemotactic behavior, has the potential to overcome major challenges of immunotherapy for glioblastoma and enhance the immune response against the tumor while preventing recurrence. [Read the Full Post]

Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

34 views | Mar 26 2023

The study found that LND is a broad-spectrum inflammasome inhibitor that directly targets ASC and may have potential as a therapeutic agent for inflammasome-driven diseases in clinic. [Read the Full Post]

Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells

55 views | Mar 26 2023

This study demonstrates that oxidative stress-induced apoptosis of lens epithelial cells in age-related cataract is regulated by E3 ligase Parkin-mediated degradation of GSTP1, providing potential targets for ARC therapy. [Read the Full Post]

Sustained response off therapy after fostamatinib: A chronic refractory ITP case report

64 views | Mar 26 2023

This case report highlights the possibility of sustained response off therapy after discontinuing fostamatinib in chronic immune thrombocytopenia. [Read the Full Post]

Cold acclimation and pioglitazone combined increase thermogenic capacity of BAT and WAT but this does not translate into higher energy expenditure

37 views | Mar 25 2023

The study found that combining cold acclimation and pharmacological PPARγ activation leads to a synergistic increase in brown and beige adipocytes UCP1 content and thermogenic capacity, but does not innately lead to higher energy expenditure. [Read the Full Post]

Circulating follistatin concentrations in adolescent PCOS: Divergent effects of randomized treatments

44 views | Mar 25 2023

This study found that oral contraceptives increase serum follistatin levels in non-obese adolescent girls with PCOS, which is associated with worsened markers of insulin resistance and changes in liver fat. [Read the Full Post]

Hyponatremia Associated with Congestive Heart Failure: Involvement of Vasopressin and Efficacy of Vasopressin Receptor Antagonists

32 views | Mar 25 2023

Hyponatremia is a common finding in congestive heart failure patients due to AVP-induced water retention, and its presence predicts poor outcomes, but the most effective treatment strategies remain unclear. [Read the Full Post]

Systemic Capillary Leak Syndrome Induced by Influenza Type A Infection: A Case Report

53 views | Mar 25 2023

This case highlights the potential for severe complications with influenza, including rhabdomyolysis and systemic capillary leak syndrome, and emphasizes the importance of prompt recognition and intensive care management. [Read the Full Post]

Evaluation of Pain and Use of Analgesics during Medical Termination of Pregnancy in Real-Life Settings

128 views | Mar 25 2023

This study evaluated pain related to medical termination of pregnancy (MToP) and its management in 23 centers in France, finding that higher doses of misoprostol were strongly associated with both pain and curative analgesic intake, while analgesic prophylaxis prescription was associated with a decreased risk of curative analgesic intake. [Read the Full Post]

Luteolin-7-O-rutinoside Protects RIN-5F Cells from High-Glucose-Induced Toxicity, Improves Glucose Homeostasis in L6 Myotubes, and Prevents Onset of Type 2 Diabetes

48 views | Mar 24 2023

Lut-7-O-rutin has been found to have a protective effect on high-glucose-induced toxicity to RIN-5F cells and improve insulin secretion and glucose uptake through various molecular mechanisms. [Read the Full Post]

Update on current contraceptive options: A case-based discussion of efficacy, eligibility, and use

37 views | Mar 24 2023

It is important for clinicians to be informed about the full spectrum of contraceptive options, including new and established methods, to improve patient reproductive autonomy and remove unnecessary barriers to contraception. [Read the Full Post]

Response to medroxyprogesterone acetate (NSC-26386) as secondary hormone therapy for metastatic breast cancer in postmenopausal women

37 views | Mar 24 2023

This study evaluated the use of medroxyprogesterone acetate in treating metastatic breast cancer in postmenopausal women and found it to be of minimal usefulness as secondary therapy. [Read the Full Post]

Antibiotic cement-coated rigid locked nails in infected femoral and tibial nonunion. Reoperation rates of commercial versus custom-made nails

26 views | Mar 24 2023

This retrospective study assessed bone union, infection control, and reoperation rates in patients with infected femoral or tibial nonunion treated with antibiotic-cement-coated rigid nails and found that custom-made nails had a higher risk of reoperation compared to commercial nails loaded with gentamicin cement. [Read the Full Post]

Molecular dynamics simulation studies of 1,3-dimethyl imidazolium nitrate ionic liquid with water

85 views | Mar 24 2023

This study investigated the intermolecular interactions between ionic liquids and water using quantum mechanics and molecular dynamics simulations and provided insights into the thermodynamic and dynamic properties of ionic liquid-water mixtures. [Read the Full Post]

DEHP Decreases Steroidogenesis through the cAMP and ERK1/2 Signaling Pathways in FSH-Stimulated Human Granulosa Cells

62 views | Mar 23 2023

DEHP inhibits the cAMP and ERK1/2 signaling pathways, leading to the inhibition of steroidogenesis in FSH-stimulated hCGC. [Read the Full Post]

Preparation and evaluation of injectable microsphere formulation for longer sustained release of donepezil

46 views | Mar 23 2023

The study developed an injectable formulation of donepezil using microspheres made of PLA or PLGA and a hydrogel wrapping, which showed sustained release and reduced inflammatory response compared to the PLGA microspheres alone. [Read the Full Post]

Clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation is increased

29 views | Mar 23 2023

The study found that clonal hematopoiesis (CH) in DNA damage response genes TP53, PPM1D, and ATM is highly prevalent in patients with severe lung disease undergoing lung transplantation and is associated with post-transplant outcomes including cytomegalovirus activation and mycophenolate intolerance. [Read the Full Post]

Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats

33 views | Mar 23 2023

The study investigated the effect of Bcrp-mediated transport, sex, and fed state on the pharmacokinetics of FUR in rats and found that Bcrp inhibition increased FUR exposure and that sex differences in Bcrp and Oat abundance in the kidney could influence PK. [Read the Full Post]

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition

46 views | Mar 23 2023

The sixth edition of the European guideline on the management of major bleeding and coagulopathy following traumatic injury provides concise, evidence-based recommendations for the management of bleeding trauma patients, emphasizing the importance of a systematic approach to reduce preventable deaths. [Read the Full Post]