TRIF

Liver X Receptor Activation Attenuates Oxysterol-Induced Inflammatory Responses in Fetoplacental Endothelial Cells

76 views | Jun 11 2023

The study suggests that 7-ketocholesterol and 7β-hydroxycholesterol induce placental inflammation in gestational diabetes mellitus by activating TLR-4 and that pharmacological activation of LXR can attenuate the pro-inflammatory effects of these oxysterols in fetoplacental endothelial cells. [Read the Full Post]

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages

81 views | Jun 11 2023

TLR4 inhibition using TAK-242 reduces CHIKV infection by decreasing viral copy number, CHIKV-E2 protein levels, and pro-inflammatory responses, highlighting TLR4 as a novel receptor involved in viral entry and modulation of infection-induced inflammation. [Read the Full Post]