Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

23 views | Jun 08 2022

Carlos R Gil Del Alcazar et al. demonstrated the usefulness of this preclinical model for immunotherapy and suggested examination to expand immunotherapy to a subset of patients with ER+ disease. [Read the Full Post]

In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system

16 views | Jun 08 2022

Ensieh Zahmatkesh et al. found that aHSCs could lead to EMT in hepatocytes during liver fibrogenesis. [Read the Full Post]

Origin of M2 Mϕ and its macrophage polarization by TGF-β in a mice intervertebral injury model

31 views | May 23 2022

Ayumu Kawakubo et al. suggested that M2 Mϕ following IVD injury might originate from resident Mϕ. [Read the Full Post]

Bone morphogenetic protein receptor inhibitors suppress the growth of glioblastoma cells

144 views | Mar 28 2022

Joel Kaye et al. suggested the need for development of BMP inhibitors and evaluation as potential therapeutic for GBMs. [Read the Full Post]

Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy

166 views | Dec 31 2021

Xiaozheng Zhao et al. found that the inhibition of ECM hyperplasia by VAC allowed TAX more ready access to the cancer cells in addition to its small size. [Read the Full Post]

Peptide-coating 2D and small chemical molecules prolong the passage of porcine spermatogonia stem cells

196 views | Dec 09 2021

Ying Zhang et al. found that feeder-free culture system optimized cell culture and might facilitate advanced research on SSC biology and genetic manipulation of germ cells. [Read the Full Post]

TGFβ1 Secreted by Cancer-Associated Fibroblasts as an Inductor of Resistance to Photodynamic Therapy in Squamous Cell Carcinoma Cells

184 views | Nov 28 2021

María Gallego-Rentero et al. found that the comparatively higher intrinsic resistance to PDT of SCC13 cells was mediated by the elevated levels of TGFβ1 secreted by this cell line. [Read the Full Post]

Reducing tumor invasiveness by ramucirumab and TGF-β receptor kinase inhibitor in a diffuse-type gastric cancer patient-derived cell model

210 views | Nov 03 2021

Song-Yi Lee et al. confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model. [Read the Full Post]

Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway

304 views | Sep 19 2021

Zhong Li et al. demonstrated the biological activity and mechanism of action of GO-based nanosheets in augmenting the osteogenic capability of hMSCs. [Read the Full Post]

High WHSC1L1 Expression Reduces Survival Rates in Operated Breast Cancer Patients with Decreased CD8+ T Cells: Machine Learning Approach

416 views | Sep 15 2021

Hyung-Suk Kim et al. found that VX-11e, CZC24832, LY2109761, oxaliplatin and erlotinib were effective in inhibiting breast cancer cell lines with high WHSC1L1 expression. [Read the Full Post]