Blog of Signaling Pathways

Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways

27 views | Nov 13 2023

Icariside II stimulates the rapid phosphorylation of eNOS at Ser1177 and Thr495 through multiple signaling pathways, leading to increased eNOS expression and nitric oxide release in human umbilical vein endothelial cells (HUVECs), suggesting its potential therapeutic relevance in conditions related to endothelial dysfunction. [Read the Full Post]

Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells

140 views | Nov 13 2023

Scutellarin (SC) inhibits metastasis in triple-negative breast cancer (TNBC) by disrupting the TNFα/TNFR2-initiated RUNX1 activation and subsequent G-CSF production in TNBC-associated endothelial cells (ECs). [Read the Full Post]

Deciphering the Allosteric Activation Mechanism of SIRT6 Using Molecular Dynamics Simulations

53 views | Nov 13 2023

This study proposes a mechanism where myristic acid and synthetic SIRT6 activators stabilize NAD+ binding and substrate interactions, shedding light on SIRT6 activation and offering insights for the design of potential therapeutic agents. [Read the Full Post]

Tumor-associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin-2

107 views | Nov 12 2023

The research reveals that tumor-associated astrocytes (TAAs) secrete lipocalin-2 (LCN2) through the STAT3 signaling pathway, promoting the progression of Sonic Hedgehog (SHH) subgroup medulloblastoma (MB) and indicating LCN2's potential as a prognostic marker and therapeutic target. [Read the Full Post]

Rituximab at lower dose for neuromyelitis optica spectrum disorder: a multicenter, open-label, self-controlled, prospective follow-up study

66 views | Nov 12 2023

The study provided evidence that a lower-dose rituximab (RTX) therapy strategy is effective and safe in treating neuromyelitis optica spectrum disorder (NMOSD), potentially changing the approach to NMOSD treatment by addressing optimal dosage and therapy initiation timing. [Read the Full Post]

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

18 views | Nov 12 2023

The study revealed that nortriptyline, an FDA-approved tricyclic antidepressant, inhibits fatty acid uptake by inducing lysosomal acidification and suppressing macropinocytosis, offering a potential strategy to control cellular fatty acid levels and address conditions such as tumor growth, lipogenesis, and hepatic steatosis. [Read the Full Post]

Axin phosphorylation in condensates counteracts tankyrase-mediated degradation

37 views | Nov 12 2023

The discovery of axin phosphorylation by casein kinase 1α within the tankyrase-binding site, hindering axin-tankyrase interaction and counteracting tankyrase-mediated degradation, represents a novel mechanism with implications for modulating Wnt signaling and potential cancer therapy. [Read the Full Post]

Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice

17 views | Nov 12 2023

The study demonstrates that the OGA inhibitor Thiamet G increases O-GlcNAc levels, reduces hyperphosphorylated tau, and ameliorates hyperactivity in a mouse model of tauopathies, suggesting its potential as a therapeutic approach for Alzheimer's disease and related conditions. [Read the Full Post]

ACSS2-mediated NF-κB activation promotes alkaliptosis in human pancreatic cancer cells

92 views | Nov 11 2023

In this hypothetical scenario, researchers have identified ACSS2 as a key regulator of alkaliptosis, a pH-dependent cell death process, and its manipulation holds promise as a potential therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC) treatment. [Read the Full Post]

ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus

29 views | Nov 11 2023

The study reveals that glutamine uptake mediated by ASCT2 plays a pivotal role in promoting Th1 differentiation through a ROS-EGR1-PAC1 pathway in oral lichen planus, suggesting that targeting ASCT2 could be a potential therapeutic approach for T cell-mediated autoimmune diseases by restoring redox balance. [Read the Full Post]

Safety and efficacy of tenalisib in combination with romidepsin in patients with relapsed/refractory T-cell lymphoma: results from a phase I/II open-label multicenter study

35 views | Nov 11 2023

The combination of tenalisib and romidepsin showed promising efficacy with a 63.0% overall objective response rate in patients with relapsed/refractory T-cell lymphoma, along with a manageable safety profile, supporting its further development as a potential treatment option. [Read the Full Post]

Segmental Zoster Paresis Accompanied by Horner's Syndrome

143 views | Nov 11 2023

In this case, a 90-year-old immunocompromised woman developed right upper limb weakness and Horner's syndrome following oral therapy for zoster on the right T2 dermatome, with aggressive intravenous treatment leading to improvement in the former but persistence of the latter. [Read the Full Post]

Homogentisate 1,2-dioxygenase (HGD) gene variants in young Egyptian patients with alkaptonuria

17 views | Nov 11 2023

In this study, the clinical and genetic spectrum of Alkaptonuria in Egypt was characterized, revealing four pathogenic missense variants, including a novel variant, in the HGD gene, and emphasizing the importance of early genetic confirmation for timely intervention with nitisinone therapy to prevent serious complications. [Read the Full Post]

The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells

0 views | Nov 10 2023

A1874, a novel BRD4-degrading PROTAC, demonstrates potent anti-colon cancer activity through both BRD4-dependent and -independent mechanisms, inhibiting cell growth, inducing apoptosis, and showing efficacy in in vivo models. [Read the Full Post]

A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

80 views | Nov 10 2023

In this experiment, a sensitive UPLC-MS/MS method was successfully validated for quantifying oprozomib concentrations in rat plasma, demonstrating its suitability for pharmacokinetic studies and potential use in assessing the treatment of haematological malignancies, including relapsed refractory multiple myeloma. [Read the Full Post]

Physalis Mottle Virus-Like Nanocarriers with Expanded Internal Loading Capacity

40 views | Nov 10 2023

The engineering of cysteine-added mutants of PhMV VLPs has significantly improved their reactivity and cargo-loading capacity, making them promising nanocarriers for precise delivery of small-molecule drugs and imaging reagents in vivo. [Read the Full Post]

The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes

33 views | Nov 10 2023

A series of copper(I) complexes combining non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine ligands demonstrated potent anti-breast cancer stem cell activity, reducing cell viability and increasing intracellular reactive oxygen species (ROS) levels, potentially opening new avenues for breast cancer treatment. [Read the Full Post]

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

41 views | Nov 10 2023

The study reveals that CDC20 negatively regulates pyroptosis by targeting GSDME for ubiquitin-mediated proteolysis in prostate cancer, and its inhibition enhances anti-tumor immunity and synergizes with anti-PD1-based immunotherapy, offering novel therapeutic avenues for this cancer type. [Read the Full Post]

Flavonoid compound from Agrimonia pilosa Ledeb improves adipose insulin resistance by alleviating oxidative stress and inflammation

22 views | Nov 09 2023

The study demonstrates that the flavonoid component (FC) extracted from Agrimonia pilosa Ledeb improves insulin resistance and glucose metabolism by regulating insulin signaling pathways, reducing oxidative stress, and attenuating inflammation, suggesting its potential as a therapeutic agent for type 2 diabetes. [Read the Full Post]

Targeting Heat Shock Protein 27 and Fatty Acid Oxidation Augments Cisplatin Treatment in Cisplatin-Resistant Ovarian Cancer Cell Lines

31 views | Nov 09 2023

Inhibition of heat shock protein 27 (HSP27) and fatty acid oxidation (FAO) in cisplatin-resistant ovarian cancer cells increases reactive oxygen species (ROS) production and sensitizes them to cisplatin treatment, while in vivo experiments show enhanced cytotoxicity of cisplatin when combined with HSP27 and FAO inhibition, suggesting potential therapeutic strategies to overcome cisplatin resistance. [Read the Full Post]