Phospholipase (e.g. PLA)

Network pharmacology integrated with molecular docking technology to reveal the potential mechanism of Shuganfang against drug-induced liver injury

26 views | Jan 12 2024

The comprehensive study on Shuganfang's mechanism in treating drug-induced liver injury through network pharmacology and molecular docking revealed multiple active ingredients, core targets, and pathways, establishing a solid foundation for its potential as a therapeutic option. [Read the Full Post]

Increased palmitoylation improves estrogen receptor alpha-dependent hippocampal synaptic deficits in a mouse model of synucleinopathy

31 views | Dec 29 2023

The study highlights how the modulation of estrogen receptor alpha (ERα) through palmitoylation plays a pivotal role in mitigating synaptic abnormalities and α-synuclein pathology, offering potential therapeutic insights for Parkinson's disease. [Read the Full Post]

Peripheral Arterial Thrombosis following Russell's Viper Bites

43 views | Nov 08 2023

This study reports three serious cases of peripheral arterial thrombosis following Russell's viper bites, emphasizing the significance of this complication in snakebite victims, while providing clinical management insights and mechanistic understanding of the procoagulant effects of Russell's viper venom. [Read the Full Post]

Cyanidin inhibits adipogenesis in 3T3-L1 preadipocytes by activating the PLC-IP3 pathway

81 views | Jul 11 2023

Cyanidin inhibits adipocyte formation by downregulating adipogenic marker gene expression and activating the PLC-IP3 pathway, leading to intracellular Ca2+ signaling. [Read the Full Post]

Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation

23 views | Jun 12 2023

The study identified several compounds, including toyocamycin and darapladib, with potent biofilm inhibitory activity against Candida species, offering potential for the development of new clinically approved antifungal agents for the treatment of Candida biofilms. [Read the Full Post]

Serum Neurofilament Light Chain in Patients With Atrial Fibrillation

23 views | Jun 12 2023

Patients with atrial fibrillation (AF) exhibit elevated levels of serum neurofilament light chain (sNFL), a marker of neuroaxonal damage, compared to controls without AF, and ongoing AF rhythm is associated with even higher sNFL levels. [Read the Full Post]

M2 Macrophage-Derived Exosomal Ferritin Heavy Chain Promotes Colon Cancer Cell Proliferation

67 views | Dec 02 2022

Zilu Cui et al. found that purified exosomes from M2 macrophages could deliver FTH1 into colon cancer cells and promote cell proliferation. [Read the Full Post]

ECM stiffness-tuned exosomes drive breast cancer motility through thrombospondin-1

181 views | Jan 08 2022

Sejal Patwardhan et al. established the pivotal role of exosomal communication in ECM stiffness dependent cell migration with exosomal THBS1 as a master regulator of cancer invasion, which can be further exploited as a potential theranostic for improved breast cancer management. [Read the Full Post]

Hypoxia-reoxygenation induces macrophage polarization and causes the release of exosomal miR-29a to mediate cardiomyocyte pyroptosis

251 views | Jan 18 2021

Yan Wang et al. found that HR treatment induced macrophage polarization towards the M1 phenotype, which mediated CM pyroptosis through exosomal miR-29a transfer by targeting MCL-1. [Read the Full Post]

Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells

781 views | Apr 12 2018

Wang Y et al. revealed unique characteristics of tanshinone-1 and its improved derivatives as promising angiogenesis inhibitors. [Read the Full Post]