MicroRNA

Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements

15 views | Feb 02 2024

The developed approach combining UV spectral deconvolution, HPLC, and microscale thermophoresis quantifies the KD for binding between active Ras and PI3K, revealing how specific Ras mutations at PI3K contact positions can significantly alter binding affinity and potentially impact cellular signaling and disease pathways. [Read the Full Post]

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors

176 views | Feb 14 2023

A population pharmacokinetic model was successfully developed for TQ-B3203, a novel topoisomerase I inhibitor, in Chinese patients with advanced solid tumors and showed that body mass index, lean body weight, and direct bilirubin were significant covariates that affected TQ-B3203 pharmacokinetics. [Read the Full Post]

Camptothecin analogs in malignant gliomas: comparative analysis and characterization

51 views | Feb 14 2023

The authors compared and characterized several new classes of camptothecin analogs and found that 10,11-methylenedioxy class consistently demonstrated the greatest cytotoxicity and hold promise for more effective local antitumor treatments against malignant intracranial brain tumors. [Read the Full Post]