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Blog of Signaling Pathways

p38 MAPK inhibitor, FR167653, a potent therapy against PTHrP-induced osteoclastogenesis and bone resorption-related diseases

3225 views | Sep 07 2011

Study on mechanism indecates that PTHrP stimulates osteoclastogenesis by increasing receptor activator of NF-kB ligand (RANKL) expression. p38 MAPK is required for osteoclast differentiation. This implies the existence of relationship between p38 MAPK and PTHrP in osteoclastogenesis. [Read the Full Post]

FGFs and the downstream signaling involve in tissue regeneration

4384 views | Sep 06 2011

FGFs have the biological activity of inducing cell proliferation, migration, differentiation, and angiogenesis. As one of the critical components in tissue regeneration, fibroblast growth factors (FGFs) shown the potential effects on the repair and regeneration of tissues. [Read the Full Post]

PI3K/Akt inhibition modulates multidrug resistance

4687 views | Sep 05 2011

Multidrug resistance (MDR), characterized by cancer cell resistance to multiple chemotherapeutic drugs, is a major clinical obstacle in the treatment of hematological malignancies. And many investigators have comfirmed that the PI3K/Akt pathway is associated with chemoresistance in cancer cells. [Read the Full Post]

Li, C., S. Chi, et al. (2011). "Hedgehog signaling in skin cancers." Cell Signal 23(8): 1235-1243.

3082 views | Aug 20 2011

This article introduces the relationship between hedgehog signal transduction and cancer including Skin cancers linked to aberrant hedgehog pathway activity, models of Hh pathway activity in cancer and implications for therapy, and inhibitors and modulators of Hh pathway and their application in skin cancers. [Read the Full Post]

Shaw, A. T. and B. Solomon (2011). "Targeting anaplastic lymphoma kinase in lung cancer." Clin Cancer Res 17(8): 2081-2086.

3856 views | Aug 19 2011

This article reviews the ALK pathway and the Clinical–Translational Advances of different ALK inhibitors. [Read the Full Post]

Kong, X., Y. Shen, et al. (2011). "Emerging roles of DNA-PK besides DNA repair." Cell Signal 23(8): 1273-1280.

4825 views | Aug 19 2011

This article reviews the role of DNA-PK from two aspects. It not only introduces the regulation of DNA-PK activity and the roles of DNA-PK in non-homologous end-joining (NHEJ) repair and homologous recombinant (HR) repair, but also introduces the involvement of DNA-PK in the inflammatory response, in metabolic gene regulation, and in the homeostasis of cell proliferation as well. [Read the Full Post]

Brinkmann, V. (2007). "Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology." Pharmacol Ther 115(1): 84-105.

3350 views | Jul 22 2011

This article reviews S1P receptor subtypes and associated signaling pathways. The relationship between S1P receptors and different diseases is proved in the article. [Read the Full Post]

Huang, H., A. Bhat, et al. (2010). "Targeting the ANGPT-TIE2 pathway in malignancy." Nat Rev Cancer 10(8): 575-585.

3375 views | Jul 20 2011

This article which is published in Nature review cancer introduce the role of Tie2 in signal transduction such as angiogenesis. It also concludes the inhibitors of Tie2 kinase in cancer therapeutics. [Read the Full Post]

Chiarle, R., C. Voena, et al. (2008). "The anaplastic lymphoma kinase in the pathogenesis of cancer." Nat Rev Cancer 8(1): 11-23.

4337 views | Jul 19 2011

This review which was published in Nature Reviews Cancer concludes the pathways which ALK is involved in and targets that ALK is related to. The content also includes ALK as a therapeutic target in cancer. [Read the Full Post]

Rosse, C., M. Linch, et al. (2010). "PKC and the control of localized signal dynamics." Nat Rev Mol Cell Biol 11(2): 103-112.

4635 views | Jul 19 2011

This review which was published in Nature review summary the role of PKC in different pathways and show the importance of PKCs in controlling spatial resolution in signaling processes using the MET and STAT3 example. [Read the Full Post]

Mumenthaler, S. M., P. Y. Ng, et al. (2009). "Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes." Mol Cancer Ther 8(10): 2882-2893.

4725 views | Jul 17 2011

These findings support the idea that inhibiting Pim kinases, in combination with a chemotherapeutic agent, could play an important role in prostate cancer treatment by targeting the clinical problem of chemoresistance. [Read the Full Post]

Wong, K. K., J. A. Engelman, et al. (2010). "Targeting the PI3K signaling pathway in cancer." Curr Opin Genet Dev 20(1): 87-90.

2382 views | Jul 16 2011

This is a short review which gives a brief introduction of PI3K and PI3K inhibitors related to cancer research. [Read the Full Post]

Dietrich, J., V. Gokhale, et al. (2010). "Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors." Bioorg Med Chem 18(1): 292-304.

2682 views | Jul 15 2011

An article about drug discovery of b-raf inhibitor design and molecular modeling. [Read the Full Post]

Munoz, L. and A. J. Ammit (2010). "Targeting p38 MAPK pathway for the treatment of Alzheimer

2687 views | Jul 14 2011

This is an introduction of the relationship between p38 MAPK and Alzheimer's disease because p38 MAPK plays an important role in Alzheimer's disease. It also list the p38 MAPK inhibitors Alzheimer's disease patients could benefit from. [Read the Full Post]

Yin, L., O. C. Velazquez, et al. (2010). "Notch signaling: emerging molecular targets for cancer therapy." Biochem Pharmacol 80(5): 690-701.

5281 views | Jul 13 2011

This article is a review which give a presentation of Notch signal pathway and how the researchers target Notch signal pathway for a cancer therapy. [Read the Full Post]

Wong, K. K. (2009). "Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway." Recent Pat Anticancer Drug Discov 4(1): 28-35.

2410 views | Jul 12 2011

Give an introduction of inhibitors targeting the Ras/Raf/ MEK/ERK pathway. This article summaries the current and future development of anti-cancer drugs or inhibitors of Ras/Raf/ MEK/ERK pathway and the difference between those drugs or inhibitors. [Read the Full Post]

Eldar-Finkelman, H., A. Licht-Murava, et al. (2010). "Substrate competitive GSK-3 inhibitors - strategy and implications." Biochim Biophys Acta 1804(3): 598-603.

4193 views | Jul 11 2011

A short article introduces the substrates and inhibitors of GSK-3 and the relationship between substrates of GSK-3 and GSK-3. [Read the Full Post]

Chipuk, J. E., T. Moldoveanu, et al. (2010). "The BCL-2 family reunion." Mol Cell 37(3): 299-310.

2881 views | Jul 9 2011

The newest review which give a overview of the BCL-2 family proteins including detail data of bcl-2 proteins, the signal transduction related to the bcl-2 and Pharmacological Regulation of the Bcl-2 Proteins [Read the Full Post]

Chin, Y. R. and A. Toker (2009). "Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer." Cell Signal 21(4): 470-476.

3176 views | Jun 23 2011

This article gives an introduction of akt signal pathway in cell motility, invasion and the tumor stroma in cancer. We can learn this overview of relationship between Akt and cancer. [Read the Full Post]

Chi V. Dang (2008)."The interplay between MYC and HIF in cancer" Nat Rev Cancer 8(1): 51-56

4315 views | Jun 14 2011

This review concludes the interaction among MYC, HIF and cancer. It also concludes the cancer cellular responses in low oxygen levels. [Read the Full Post]