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Blog of Signaling Pathways

The new finding of PI3K signaling regulation provides a novel therapeutic strategy for luminal breast cancer

7241 views | Jan 15 2015

Costa et al. found the high efficiency of p110α inhibition by BYL719 is attenuated due to p110β accumulation. [Read the Full Post]

Tofacitinib promotes myeloid-derived suppressor cells expansion and reduces disease severity of arthritis SKG mice

5854 views | Jan 14 2015

Nishimura et al. revealed that tofacitinib has effect on promoting MDSCs expansion and ameliorating arthritis in SKG mice. [Read the Full Post]

The important role of Cav1 in inducing peritoneal membrane epithelial-mesenchymal transition and fibrosis

2245 views | Jan 13 2015

Strippoli et al. found Caveolin-1 (Cav1) acts as a critical factor in the increasing epithelial-mesenchymal transition (EMT), thickness, and fibrosis of peritoneum during peritoneal dialysis. [Read the Full Post]

The mechanism of kinase independent AKT in promoting cancer development

5099 views | Jan 12 2015

Vivanco et al. revealed the mechanism and emphasized a kinase-independent function of AKT in regulating cancer cell survival. [Read the Full Post]

Inflammatory signaling plays a critical role in vertebrates embryonic hematopoiesis

1992 views | Jan 09 2015

He et al. found inflammatory signaling is critical in zebrafish and mouse embryonic hematopoiesis without infection or pathological inflammation. [Read the Full Post]

Generate hypothalamic neurons from hESCs and human iPSCs

3336 views | Jan 08 2015

Wang et al. reported a protocol of differeiciating human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) into hypothalamic cells. [Read the Full Post]

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

10197 views | Jan 07 2015

Winter et al. identified the underlying mechanism of the emerging JAK2 inhibitor therapy resistance in MPNs patients, and found the RAS and pathways mediated by AKT and ERK contribute to the resistance. [Read the Full Post]

An unusual mechanism of ERBB4 in regulating tumor related gene expression

8146 views | Jan 06 2015

Haskins et al. found ERBB4 activated the transcriptional coactivator YAP by binding to its ligand neuregulin 1 (NRG1), to regulate gene expression of cancer cells. [Read the Full Post]

Resvertrol targets a human tRNA synthetase for activation of NAD+-dependent PARP1

4549 views | Jan 05 2015

Mathew Sajish and Paul Schimmel found resvertrol interacts with tyrosyl transfer-RNA (tRNA) synthetase (TyrRS), which translocates to the nucleus in response to stress, to initiating its effect in nuclear. [Read the Full Post]

The important role of immune microenvironment in resistance to MAPK pathway-targeted therapy

1868 views | Jan 04 2015

Smith et al. demonstrated that the factors within immune microenvironment can promote the resistance to mitogen-activated protein kinase (MAPK) pathway-targeted therapy. [Read the Full Post]

Two states of BRAFV600 mutant melanoma that related to MAPK inhibition resistance

6210 views | Dec 31 2014

Konieczkowski et al. revealed the mechanism of MAPK inhibition on BRAFV600 mutant melanomas. [Read the Full Post]

The mechanism of GSI resistance in T cell acute lymphoblastic leukemia

4998 views | Dec 30 2014

Knoechel et al. identified BRD4 is an important regulator of GSI resistance in T-ALL cells, and the combination of GSI and JQ1, the BRD4 inhibitor, is effective against T-ALL in vivo. [Read the Full Post]

The important role of HSF1 expressed by cancer-associated fibroblasts

3505 views | Dec 29 2014

Scherz-Shouval et al. found cancer-associated fibroblasts (CAFs) frequently express heat shock factor 1 (HSF1), which acts as a strong enabler of tumorigenesis. [Read the Full Post]

Cep68 act as an important linker protein of centrosomes and centriole disengagement

4247 views | Dec 26 2014

Pagan et al. indentified the important roles of Cep68 and other related factors during the disengagement of centrosomes and entrioles. [Read the Full Post]

The mechanism of action of new antitumor drug FL118

3496 views | Dec 25 2014

Recently, Ling et al. demonstrated the mechanism of FL118 antitumor action. The drug suppress tumor growth by promotion of MdmX degradation and consequent stimulation of p53 signaling. [Read the Full Post]

Endophilin plays a central role in endocytic pathway without calthrin

2439 views | Dec 24 2014

Recently, Boucrot et al. demonstrated endophillin participates in a clathrin-independent endocytic pathway, as a central component. [Read the Full Post]

Innate immunity-induced IRF3 signaling suppress TGF-β via Smad

4850 views | Dec 23 2014

By investigating the innate host defense, Xu et al. found RIG-I-Like receptor (RLR) signaling suppress TGF-β via activation of Interferon regulatory factor 3 (IRF3). [Read the Full Post]

CCR4 mutations act as key factors in adult T-cell leukemia/lymphoma pathogenesis

3822 views | Dec 22 2014

Nakagawa et al. reported the dysregulation of CCR4 is critical in ATLL pathogenesis, and the inhibition of CCR4 signaling may have clinical value for curative treatment of ATLL. [Read the Full Post]

ABL1, a new target of oxidative stress related rental cancer

4724 views | Dec 19 2014

Sourbier et al. used hereditary kidney cancers as a model to investigate mechanism-based therapeutic interventions by metabolic adaptations. They found the activation of ABL1, an proto-oncogene, is critical in tumors that relate to glycolysis and oxidative stress. [Read the Full Post]

Novel approach of genetic perturbation

2007 views | Dec 18 2014

Konermann et al. built a CRISPR-Cas9 complex for the regulation of effective transcriptional activation at target genomic loci. [Read the Full Post]