Blog of Signaling Pathways

Discovery of novel Quinazoline-based KRAS G12C inhibitors as potential anticancer agents

20 views | Oct 06 2022

Ling Li et al. found that KS-19 represents a novel inhibitor of KRAS G12C worthy of further investigation as a potential anticancer agent. [Read the Full Post]

Oil-free eye drops containing Cyclosporine A/cyclodextrin/PVA supramolecular complex as a treatment modality for dry eye disease

50 views | Oct 06 2022

Pinal Chaudhari et al. demonstrated the potential of the supramolecular complex as an alternative to the oil-based formulation of eye drops for drugs that showed low solubility and poor corneal permeation. [Read the Full Post]

Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors

8 views | Oct 04 2022

Surabhi Talele et al. found that AZD1390 is an attractive molecule for clinical development of brain tumors. [Read the Full Post]

Int J Oncol . 2022 Oct;61(4):114. doi: 10.3892/ijo.2022.5404. Epub 2022 Aug 3. Targeting PIM2 by JP11646 results in significant antitumor effects in solid tumors

105 views | Oct 04 2022

Eriko Katsuta et al. found that JP11646 may thus be a possible treatment strategy for multiple types of solid cancers. [Read the Full Post]

BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer

79 views | Oct 03 2022

Prashanthi Ramesh et al. found a cell transferable induction of a FGF2/FGFR4 rescue response in CRC that was induced upon BCL-XL inhibition and lead to MCL-1 upregulation. [Read the Full Post]

Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors

37 views | Oct 03 2022

Koki Chiba et al. found that imatinib suppressed ventricular active relaxation and early repolarization, which might suggest the association of mitochondrial dysfunction-associated inhibition of ATP production. [Read the Full Post]

ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

0 views | Oct 02 2022

Yan Gu et al. found that ABHD5 interacted in the cytoplasm with the core subunit of the SET1A methyltransferase complex, DPY30, thereby inhibiting the nuclear translocation of DPY30 and activity of SET1A. [Read the Full Post]

The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

45 views | Oct 02 2022

Youjie Yin et al. identified CRTC/CREB downstream ROS/JNK signaling as a conserved sensor to tackle oxidative and proteotoxic stresses. [Read the Full Post]

RIPK3 inhibitor-AZD5423 alleviates acute kidney injury by inhibiting necroptosis and inflammation

49 views | Oct 01 2022

Chuan-Hui Xu et al. found that AZD5423 may serve as a potent inhibitor of RIPK3 kinase and a promising clinical candidate for AKI treatment. [Read the Full Post]

Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

21 views | Oct 01 2022

Andrea Lopez et al. advanced the understanding of apoptosis resistance mechanisms and demonstrate a novel therapeutic strategy for cancer treatment. [Read the Full Post]

Hepatocellular carcinoma-derived exosomal miRNA-761 regulates the tumor microenvironment by targeting the SOCS2/JAK2/STAT3 pathway

40 views | Sep 30 2022

Xiao-Hu Zhou et al. found that exosomal miR-761 modulated the tumor microenvironment via SOCS2/JAK2/STAT3 pathway-dependent activation of CAFs. [Read the Full Post]

Temsirolimus Enhances Anti-Cancer Immunity by Inducing Autophagy-Mediated Degradation of the Secretion of Small Extracellular Vesicle PD-L1

111 views | Sep 29 2022

Seong-Sik Park et al. suggested that TEM, previously known as a targeted anti-cancer drug, could overcome the low reactivity of ICBT by inhibiting sEV PD-L1 and cellular PD-L1 levels. [Read the Full Post]

Targeting Akt/PKB in pediatric tumors: A review from preclinical to clinical trials

55 views | Sep 29 2022

Bruno Toson et al. demonstrated the impact that Akt inhibition provided in tumorigenesis, and suggested targeting the PI3K/Akt/mTOR signaling pathway, alone or in combination with other inhibitors, was a feasible tool to achieve better outcomes in pediatric tumors. [Read the Full Post]

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling

41 views | Sep 28 2022

Dawei Zhou et al. demonstrated that depletion or inhibition of SUPT16H caused the remarkable activation of IFN signaling in NK cells, which promoted the NK-mediated killing of virus-infected cells in a co-culture system using human primary NK cells. [Read the Full Post]

In silico drug repurposing and lipid bilayer molecular dynamics puzzled out potential breast cancer resistance protein (BCRP/ABCG2) inhibitors

68 views | Sep 28 2022

Nahlah Makki Almansour et al. identified zotarolimus, temsirolimus and glecaprevir as auspicious anti-MDR drug leads that warrant further experimental assays. [Read the Full Post]

Subtype and site specific-induced metabolic vulnerabilities in prostate cancer

32 views | Sep 27 2022

Federica Mossa et al. thought that castration-resistant ARPC and AVPC exhibited different metabolic dependencies, which could further undergo metabolic reprogramming in bone. [Read the Full Post]

Menin‑MLL inhibitors induce ferroptosis and enhance the anti‑proliferative activity of auranofin in several types of cancer cells

0 views | Sep 27 2022

Ichiroh Kato et al. thought that the MI‑463‑induced decreased in cell viability might be at least partly associated with the inhibition of SCD1 activity. [Read the Full Post]

Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells

49 views | Sep 26 2022

Hongfei Zhou et al. suggested that EBR could be considered as a potential therapeutic compound for HCC due to its pro-apoptosis, restriction of energy metabolism, and other anti-cancer properties. [Read the Full Post]

Case Report of CCDC149-ALK fusion: a novel genetic alteration and a clinically relevant target in metastatic papillary thyroid carcinoma

30 views | Sep 26 2022

Hannah Lee et al. recommend deep mutational sequencing in BRAFV600E-negative, RAIR PTC to identify targetable genetic alterations, including gene fusions, that might result in dramatic therapeutic benefits. [Read the Full Post]

Reducing tumor invasiveness by ramucirumab and TGF-β receptor kinase inhibitor in a diffuse-type gastric cancer patient-derived cell model

36 views | Sep 25 2022

Song-Yi Lee et al. confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model. [Read the Full Post]