Blog of Signaling Pathways

Novel approach of genetic perturbation

2338 views | Dec 18 2014

Konermann et al. built a CRISPR-Cas9 complex for the regulation of effective transcriptional activation at target genomic loci. [Read the Full Post]

The inhibition of JAK signaling promotes the conversion from white to brown adipocytes

8373 views | Dec 17 2014

By using a screening platform of small molecules identification, Moisan et al. found two inhibitors of JAK signaling were able to convert white adipocytes to brown adipocytes. [Read the Full Post]

The Notch signaling controls maintenance of memory CD4+ T cells

9859 views | Dec 16 2014

Recently, Maekawa et al. demonstrated Notch signaling is important for the survival of memory CD4+ T cells by regulating glucose uptake. [Read the Full Post]

The inhibition of BET leads to a suppression of osteoclastogenesis

3126 views | Dec 15 2014

Park-Min et al. found the inhibitor of bromo and extra-terminal (BET), I-BET151, can strongly reduce osteocelstogenesis. [Read the Full Post]

The early resistance to BARF(V600)-mutant melanoma is triggered by reactivation of MAPK pathway

3166 views | Dec 12 2014

In regards to mechanism of emerging drug resistance, Long et al. demonstrated MAPK pathway was reactivated in early stage of resistance to combination therapy. [Read the Full Post]

The inhibitor of CCR5 block metastasis of v-Src oncogene-transformed prostate cancer

3474 views | Dec 11 2014

Sicoli et al. identified CCR5 signaling activation is important for v-Src oncogene-transformed prostate cancer metastasis, and it antagonist can attenuate the burden. [Read the Full Post]

The HGF/cMET signaling promotes angiogenesis in bone marrow endothelial cells

2617 views | Dec 10 2014

Ferrucci et al. demonstrated hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (cMET) pathway plays an important role in regulation angiogenesis. [Read the Full Post]

IncRNA BCAR4 regulates cancer development cooperated with chemokine signals

7186 views | Dec 09 2014

Xing et al. demonstrated the mechanism of BCAR4, a disease-related Inc RNA, in regulation signaling pathways in breast cancer metastasis. [Read the Full Post]

The binding of mutant p53 and DAB2IP increase the invasion of inflammation induced cancer cells

4706 views | Dec 08 2014

Minin et al. inflammatory cytokines can increase the invasive behavior of cancer cells with p53 missense mutants (mutp53). [Read the Full Post]

Hippo signaling mediates hypoxia tumorgenesis via SIAH2

4308 views | Dec 05 2014

Ma et al. gives a insight into the mechanism of Hippo signaling by investigating the pathway deactivation induced by hypoxia. [Read the Full Post]

MeCP2 S421 phosphorylation mediates neurogenesis via Notch signaling pathway

8577 views | Dec 04 2014

Li et al. identified the Notch signaling is involved in the regulation of MeCP2 S421 phosphorylation other than neuronal activity. [Read the Full Post]

VEFG/SphK pathway plays an important role in Niemann-Pick type C disease

4306 views | Dec 03 2014

Lee et al. identified the defective of sphingosine kinase (SphK) and vascular endothelial growth factor (VEGF) activities are main signaling that promotes sphingosine storage. [Read the Full Post]

Retinoic acid and Wnt signaling are key regulators in development of hematopoietic stem cells

6442 views | Dec 02 2014

Chanda et al. identified retinoic acid (RA) and Wnt signaling pathways as key mediators of HSC development. [Read the Full Post]

KIAA1199 provides a connection between oncogenic signaling of NF-κB and EGFR

6282 views | Dec 01 2014

Shostak et al. showed the connection between the two oncogenic cascades by identifying a key factor, KIAA1199, that associated with human papillomavirus (HPV) infection. [Read the Full Post]

Mechanism of Cdo-induced Wnt suppression during neuronal differentication

4508 views | Nov 28 2014

Jeong et al. found that Wnt signaling is negatively regulated by Cdo, a Shh multifunctional co-receptor which is highly expressed in the central nervous system, in order to promote neuronal differentiation. [Read the Full Post]

Quickly switching of spindle checkpoint states is due to negative feedback at kinetochrores

4398 views | Nov 27 2014

Nijenhuis et al. found this phenomenon arises due to localized negative feedback of spindle assemble checkpoint (SAC) signal, which ensure kinetochres switch SAC signalling OFF rapidly. [Read the Full Post]

mTOR is a key regulator of rental sodium homeostasis

2302 views | Nov 26 2014

Gleason et al. examined the role of mTOR in regulation of ion transport in ASDN, and demonstrated mTOR played a key role in the regulation of Na+ homeostasis, via SGK1-dependent modulation of ENaC activity. [Read the Full Post]

Semen suppresses antiviral activities of microbicides against HIV

2898 views | Nov 25 2014

Zirafi et al. reported that microbicides, which can target HIV components, showed ineffective in the presence of semen. [Read the Full Post]

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

10990 views | Nov 24 2014

Dechow et al. determined GP130/JAK/STAT3 signaling pathway is sufficient to induce MM generation in mice retroviral murine BM transduction-transplantation model. [Read the Full Post]

ERK/Cdk5 axis regulates diabetes-related PPARγ phosphorylation

7869 views | Nov 21 2014

Recently, Banks et al. discovered that ERK/Cdk5 axis is involved in regulation PPARγ activities, and the inhibition of ERK and MEK leads to the improvement of insulin resistance. [Read the Full Post]