Blog of Signaling Pathways

Chemical characterization of Brazilian savannah Byrsonima species (muricis) and their impact on genomic instability and chemopreventive effects

75 views | Apr 27 2023

The study evaluated the potential of extracts from Byrsonima genus plants found in the Brazilian savannah as natural alternatives in cancer prevention and treatment, identifying B. correifolia and B. verbascifolia extracts as potential agents against hepatocarcinoma and B. crassifolia and B. intermedia extracts as putative chemopreventive agents. [Read the Full Post]

Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy

46 views | Apr 27 2023

This study found that an opioid-free injectable anaesthetic protocol with multimodal analgesia provided effective pain relief and reduced the need for rescue analgesia in kittens undergoing ovariohysterectomy, while also observing a decrease in food intake due to pain. [Read the Full Post]

The effect of rifampin on serum etonogestrel concentrations and biomarkers of ovulation among contraceptive implant users: a pharmacokinetic and pharmacodynamic study

45 views | Apr 27 2023

Short-term exposure to rifampin, a strong CYP3A inducer, can lead to clinically significant decreases in serum ENG concentrations and changes in biomarkers indicative of waning suppression of ovulation in ENG implant users. [Read the Full Post]

Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study

42 views | Apr 27 2023

The study investigated the association between CYP2B6 polymorphisms and efavirenz drug resistance among women living with HIV who started on antiretroviral therapy during pregnancy and had high viremia in the postpartum period, and found no statistically significant difference in EFV resistance between EFV metabolizer genotypes, but a numerical trend was observed, calling for further confirmation in a large, well-designed, statistically powered study. [Read the Full Post]

Positron Emission Tomography Imaging in Vasculitis

81 views | Apr 27 2023

FDG-PET/CT is an important imaging tool in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels, and with advancements in newer generation scanners and development of novel tracers, it has shown significant potential in accurately assessing the full disease extent and detecting vascular infiltrates. [Read the Full Post]

Highly Sensitive Imaging of Tumor Metastasis Based on the Targeting and Polarization of M2-like Macrophages

77 views | Apr 26 2023

This research developed a nanoprobe that targets M2-like macrophages to track their migration and polarization in real-time during tumor metastasis, revealing their critical role in early tumor metastasis. [Read the Full Post]

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

94 views | Apr 26 2023

The study investigates the interaction of small molecule ferroptosis inducers with ABC transporters, specifically P-glycoprotein and ABCG2, highlighting their potential role in limiting bioavailability and brain penetration of these inducers and predicting drug-drug interactions. [Read the Full Post]

Nrf2 transcriptional activity in the mouse affects the physiological response to tribromoethanol

19 views | Apr 26 2023

The study found that Avertin causes prolonged anesthesia in tNrf2-/- mice without acute toxicity, inflammatory reaction, or enhanced oxidative stress, and can normalize enhanced fibrosis without impairing intestine morphology in tNrf2-/- mice. [Read the Full Post]

Regulatory effects of trimetazidine in cardiac ischemia/reperfusion injury

45 views | Apr 26 2023

MicroRNAs such as miR-21, miR-24, and miR-126, as well as trimetazidine, may have protective effects on myocardial ischemia/reperfusion injury by regulating gene expression and inducing key regulators such as AMPK, CSE/H2S, and miR-21. [Read the Full Post]

Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents

28 views | Apr 26 2023

The review covers recent developments in the discovery of new therapeutic options for Human African Trypanosomiasis, including patents related to new antitrypanosomiasis agents, biological targets, vaccines, and formulations, as well as the selectivity and toxicity of natural and synthetic compounds against human cells. [Read the Full Post]

Comparison of in vitro Susceptibilities of Talaromyces marneffei in Mold and Yeast Forms in Malaysia

29 views | Apr 25 2023

The study found that the susceptibility of T. marneffei to most antifungal drugs was similar for both yeast and mold forms, except for caspofungin and micafungin, which had significant differences in GM MIC. [Read the Full Post]

Plasma and Cerebrospinal Fluid Concentrations of Micafungin Administered at High Doses in Critically Ill Infants with Systemic Candidiasis: A Pooled Analysis of Two Studies

43 views | Apr 25 2023

The pharmacokinetics of micafungin were analyzed in 53 neonates with systemic candidiasis, revealing that neonates may require higher doses of micafungin than adults to reach therapeutic levels, and micafungin crosses the blood-brain barrier reaching therapeutic levels in CSF with doses ranging between 8 and 15 mg/kg/day. [Read the Full Post]

Auranofin Targeting the NDM-1 Beta-Lactamase: Computational Insights into the Electronic Configuration and Quasi-Tetrahedral Coordination of Gold Ions

63 views | Apr 25 2023

Recent research has demonstrated that auranofin can restore penicillin and cephalosporin sensitivity in resistant bacterial strains via the inhibition of the NDM-1 beta-lactamase enzyme, accomplished through substituting gold for zinc in the enzyme's bimetallic core. [Read the Full Post]

Therapeutic Options for Adult Patients With Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Narrative Review

73 views | Apr 25 2023

The available evidence suggests that a combination of antibiotics targeting MSSA, along with source control measures and consultation with an infectious diseases specialist, may be necessary to effectively manage persistent MSSA bacteremia. [Read the Full Post]

Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model

29 views | Apr 25 2023

The study found that transdermal N-89 combined with mefloquine or pyrimethamine provided a promising antimalarial form for children, with a synergistic effect and better antimalarial activity and cure effect compared to N-89 alone or combined with chloroquine. [Read the Full Post]

Characterization of the Interactions between Minocycline Hydrochloride and Trypsin with Spectroscopic and Molecular Docking Technology

85 views | Apr 24 2023

This study investigated the interaction between minocycline hydrochloride and trypsin using various spectroscopic and molecular docking techniques and demonstrated its impact on the secondary structure of trypsin. [Read the Full Post]

Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells

133 views | Apr 24 2023

The study found that immune checkpoint inhibitors can either potentiate or depotentiate the cytotoxic effects of chemotherapy in lung adenocarcinoma cell lines with different PD-L1 expression levels, and the specific effects vary depending on the ICIs and chemotherapy agents used. [Read the Full Post]

The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

69 views | Apr 24 2023

The research shows that the transcription factor Nrf3 regulates macropinocytosis and autophagy to coordinate melanogenesis, and has potential therapeutic implications for hyperpigmentation disorders and as an anti-melanogenic target in HIV-1 infected individuals taking nelfinavir. [Read the Full Post]

Targeting chromosome 12q amplification in relapsed glioblastoma: the use of computational biological modeling to identify effective therapy-a case report

67 views | Apr 24 2023

The case report demonstrates the utility of biosimulation in identifying effective treatment options based on comprehensive genomic abnormalities and highlights a promising treatment combination for GBM and potentially other cancers harboring chromosome 12q amplification. [Read the Full Post]

PK/PD modeling and simulation of the in vitro activity of the combinations of isavuconazole with echinocandins against Candida auris

45 views | Apr 24 2023

The study used a pharmacokinetic/pharmacodynamic modeling and simulation approach based on in vitro data to predict the in vivo response to combination therapy against Candida auris, highlighting the importance of bridging in vitro results to the clinic. [Read the Full Post]