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Hippo

Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

0 | Oct 18 2021

Jingjing Zhang et al. found unrecognized functions of astrocytic YAP in the prevention of demyelination through promoting cholesterol synthesis in EAE, and revealed a novel pathway of YAP/HMGCS1 for cholesterol synthesis in EAE pathology. [Read the Full Post]

In silico evaluation of the downstream effect of mutated glucagon is consistent with higher blood glucose homeostasis in Galliformes and Strigiformes

10 | Oct 11 2021

Karim Mahnam et al. suggested this mutation, which leaded to stronger binding affinity of mutated glucagon to its receptor, might be a driving force for higher blood glucose homeostasis in the related birds. [Read the Full Post]

Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid

12 | Oct 10 2021

Léa Mélin et al. found that LM98 reduced the expression of CTGF and Cyr61, inhibited MDA-MB-231 breast cancer cell migration and arrested cell cycling in the S phase during cell division. [Read the Full Post]

Treatment outcomes of erlotinib plus gemcitabine as late-line chemotherapy in unresectable pancreatic cancer

125 | Jun 16 2021

Takafumi Mie et al. found that benefits of erlotinib plus gemcitabine as late-line chemotherapy were limited, particularly with respect to PFS. [Read the Full Post]

Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms

153 | Jan 12 2021

Antoine Kavaye Kandeda et al. suggested that anti-inflammatory mechanisms were involved in the antiepileptogenic effect of P. daemia extract. [Read the Full Post]

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice

88 | Oct 22 2020

Qiuyun Tian et al.suggested that inhibition of YAP pathway could be a potential therapeutic target for anxiety-like behavior induced by neuro-inflammation. [Read the Full Post]

Circulating glucagon-like peptide-1 level in patients with liver cirrhosis

79 | Oct 13 2020

Masoud Nouri-Vaskeh et al. found that larger prospective studies were needed to explore the incretin effect in cirrhosis patients compared with healthy individuals. [Read the Full Post]

TM4SF1 facilitates non-small cell lung cancer progression through regulating YAP-TEAD pathway

93 | Oct 10 2020

X-Y Fu et al. demonstrated that TM4SF1 could promote proliferation, migration, and invasion in NSCLC, at least partially through a potential YAP-TEAD signaling pathway-dependent mechanism. [Read the Full Post]