Blog of Signaling Pathways

Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq

110 views | Apr 19 2023

The combination of network pharmacology and deep RNA-seq analysis provides valuable insights into the molecular mechanisms of TPL nephrotoxicity, identifying potential targets and signaling pathways for further investigation. [Read the Full Post]

Effect of trichloroethanol on TLR2 and TLR4/NF-κB-mediated antigen processing and presentation in HLA-B* 13:01-transfected antigen-presenting cells

75 views | Apr 19 2023

Trichloroethanol (TCOH) may contribute to the pathogenesis of trichloroethylene-induced hypersensitivity dermatitis through activation of the TLR2 and TLR4/NF-κB pathway and upregulation of molecules involved in antigen processing and presentation, leading to the reactivation of T lymphocytes and an extreme immune response. [Read the Full Post]

Nogo-A Mediated Endoplasmic Reticulum Stress During Myocardial Ischemic-Reperfusion Injury in Diabetic Rats

29 views | Apr 19 2023

The study suggests that Nogo-A mediated ER stress plays a major role in diabetic MI/R injury, and pathologically altered Nogo-A expression mediates diabetic MI/R injury, suggesting Nogo-A as a potential target for the treatment of diabetic MI/R injury in clinical settings. [Read the Full Post]

Targeting mitochondrial stress with SS31 prevents experimental abdominal aortic aneurysm: crosstalk with ER stress

36 views | Apr 19 2023

The study demonstrates that inhibition of mitochondrial stress with SS31 limits AAA formation and increases survival through a reduction of vascular remodeling, inflammation, and ROS, and also supports the idea that the attenuation of ER stress contributes to the favorable response. [Read the Full Post]

Bacterial species and antimicrobial resistance differ between catheter and non-catheter-associated urinary tract infections: Data from a national surveillance network

43 views | Apr 19 2023

The study found that CAUTI pathogens were more often resistant to recommended empirical antibiotics than non-CAUTI pathogens, emphasizing the need for urine sampling for culturing before initiating therapy for CAUTI and the importance of considering therapeutic alternatives. [Read the Full Post]

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

33 views | Apr 18 2023

High-throughput screening has identified ML198 and ML266 as chemical series that can facilitate translocation of mutant GCase to the lysosome without inhibiting the enzyme's activity, providing a potential starting point for the development of small molecule treatments for Gaucher disease. [Read the Full Post]

The effect of pentosan polysulfate sodium for improving dyslipidaemia and knee pain in people with knee osteoarthritis: A pilot study

68 views | Apr 18 2023

The study found that pentosan polysulfate sodium (PPS) has promising effects on improving dyslipidemia and providing symptomatic pain relief in people with knee osteoarthritis (OA), but further studies with larger sample sizes and more rigorous study designs are needed to confirm these findings. [Read the Full Post]

Microglial VDAC1 signaling modulates sleep deprivation-induced transition to chronic postsurgical pain

43 views | Apr 18 2023

This study demonstrates that sleep deprivation before and after surgery increases the risk of chronic pain by activating spinal microglia, and that VDAC1 signaling regulates microglial activation-related ATP release, inflammation, and pain chronicity in mice. [Read the Full Post]

ARRY-382 in Combination with Pembrolizumab in Patients with Advanced Solid Tumors: Results from a Phase 1b/2 Study

57 views | Apr 18 2023

This study found that ARRY-382 plus pembrolizumab was well-tolerated but provided limited clinical benefit in patients with advanced solid tumors. [Read the Full Post]

Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis

149 views | Apr 18 2023

The study showed that a combination of organ-protective ingredients from Lysimachia christinae could protect against triptolide-induced multi-organ injury in vivo by activating the AKT/mTOR pathway and reducing cell death including ferroptosis and apoptosis inhibition. [Read the Full Post]

Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket

46 views | Apr 17 2023

The discovery of small-molecule CPS1 inhibitors that bind to an allosteric pocket to block ATP hydrolysis is a promising development for targeting CPS1 overexpression in cancer cells and could provide valuable tools for researchers studying CPS1 cancer biology. [Read the Full Post]

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ

109 views | Apr 17 2023

RBPJ Inhibitor-1 (RIN1) is a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, which can be exploited for chemical biology and therapeutic applications, and may lead to more specific and targeted therapies for diseases involving NOTCH signaling. [Read the Full Post]

Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8+ T cells in hepatocellular carcinoma

44 views | Apr 17 2023

This study suggests that targeting the RBPJ transcription complex with a small molecule compound may be a promising strategy for immunotherapy of hepatocellular carcinoma by inhibiting the malignant behaviors of HCC cells and alleviating T cell exhaustion. [Read the Full Post]

An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses

24 views | Apr 17 2023

The approval of tecovirimat and brincidofovir for smallpox treatment, and their demonstrated efficacy against monkeypox, has reignited interest in the development of orthopoxvirus antivirals to combat potential outbreaks of related viruses. [Read the Full Post]

Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV

43 views | Apr 17 2023

The study found that Rh108-dependent late gene expression is required for the induction of MHC-E-restricted T cells and protection against SIV in rhesus macaques vaccinated with RhCMV/SIV vectors. [Read the Full Post]

Low level of antifungal resistance in Candida species recovered from Iranian HIV-associated oral infection

49 views | Apr 16 2023

The study found a high prevalence of oral candidiasis among PLWHA following HAART, and highlighted the need to understand the mechanisms of reduced susceptibility and low-level resistance in Candida species and consider local epidemiology in their management. [Read the Full Post]

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations

35 views | Apr 16 2023

The study found that Candida auris isolates with FKS1 mutations were resistant to echinocandins in vivo, including micafungin and caspofungin, and that mutations in R1354 resulted in in vivo resistance despite remaining below the micafungin breakpoint in vitro. [Read the Full Post]

A 2023 update on the advancements in the treatment of agitation in Alzheimer's disease

98 views | Apr 16 2023

Recent advances in the understanding of neurobiological mechanisms of agitation in Alzheimer's Disease have led to the identification of several agents with promise for treating agitation, and clinical trials are underway to develop safe and efficacious treatment options. [Read the Full Post]

Vitamin C promoted refractory organic contaminant elimination in the zero-valent iron/peracetic acid system: Efficiency, mechanism and effects of various parameters

97 views | Apr 16 2023

This study proposes using vitamin C as a reducing agent to enhance the performance of the conventional ZVI/PAA system for the degradation of contaminants in water, leading to improved removal efficiency and potential for achieving a cleaner water environment. [Read the Full Post]

Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations

78 views | Apr 16 2023

MAO-B and COMT inhibitors are important strategies for managing motor fluctuations in Parkinson's disease patients, with several drugs available on the market targeting these enzymes, and ongoing studies exploring new formulations and combinations of these inhibitors. [Read the Full Post]