Blog of Signaling Pathways

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model

23 views | Feb 04 2024

This study reveals disrupted tight junction integrity, impaired transporter functionality, and decreased Aβ-receptor binding at the blood-brain barrier in Alzheimer's disease, prompting potential therapeutic strategies targeting these specific alterations. [Read the Full Post]

Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway

28 views | Feb 04 2024

Adelmidrol demonstrates promise in ameliorating liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway, as evidenced by its reduction of inflammatory response, oxidative stress, and apoptosis in both mouse liver I/R injury models and AML12 cell hypoxia-reoxygenation experiments. [Read the Full Post]

Functional groups matter: metabolomics analysis of Escherichia coli exposed to trans-cinnamic acid and its derivatives unveils common and unique targets

9 views | Feb 04 2024

This study employing a metabolomics approach revealed distinctive metabolic responses in Escherichia coli to trans-cinnamic acid, p-coumaric acid, and ferulic acid, indicating diverse impacts on bacterial metabolism and cellular processes. [Read the Full Post]

Exportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis

13 views | Feb 04 2024

The intricate interplay between the AAA+ ATPase Pch2, Crm1 exportin-mediated nucleocytoplasmic transport, and the identification of a specific Nuclear Export Signal within Pch2 unveils a crucial regulatory mechanism governing its cellular distribution and function during meiosis. [Read the Full Post]

Frailty and risk of serious infections in patients with rheumatoid arthritis treated with biologic or targeted-synthetic DMARDs

44 views | Feb 04 2024

Frailty significantly amplifies the risk of serious infections and hospitalizations in rheumatoid arthritis patients starting biologic or targeted synthetic disease-modifying drugs, emphasizing the crucial need for tailored interventions in higher-risk populations. [Read the Full Post]

Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH

50 views | Feb 03 2024

The versatile TPE-FdU fluorescent probe, exhibiting pH-responsive behavior, selective Hg2+ ion detection, and intracellular mitochondrial visualization, represents a promising advancement with diverse applications in cell imaging, environmental monitoring, and biomedical research. [Read the Full Post]

Highly Potent Peptide Therapeutics To Prevent Protein Aggregation in Huntington's Disease

16 views | Feb 03 2024

Peptide-based therapies exhibiting inhibition of mHtt fibril formation present a promising avenue for halting the progression of Huntington's disease by targeting the misfolded proteins associated with the condition. [Read the Full Post]

Characterization of a (p)ppApp Synthetase Belonging to a New Family of Poly

19 views | Feb 03 2024

This study characterizes the MuF-RelA_SpoT polymorphic toxin in Streptococcus pneumoniae SPNA45, revealing its (p)ppApp synthetase activity and the downstream genes encoding immunity proteins, while proposing a distinguishing signature for (p)ppApp synthetases. [Read the Full Post]

Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion

20 views | Feb 03 2024

Reduced retinoic acid signaling, induced by inhibitors or ethanol exposure, disrupts early neuroectodermal network regulation, increasing neural precursor proliferation and expanding the neural plate, thereby leading to the induction of neural tube defects during embryogenesis. [Read the Full Post]

Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin- annonacin from Annona muricata L

30 views | Feb 03 2024

The study's findings suggest that annonacin from Annona muricata has the potential to counteract drug resistance in colorectal cancer cells by inhibiting P-glycoprotein-mediated drug efflux, highlighting a promising avenue for future therapeutic developments. [Read the Full Post]

Pluronic F-127 Enhances the Antifungal Activity of Fluconazole against Resistant Candida Strains

17 views | Feb 02 2024

The study investigates how Pluronic F-127 (PLX) formulations loaded with fluconazole (FLU) potentially increase susceptibility in drug-resistant Candida strains, revealing a significant inhibitory effect on yeast growth, particularly at concentrations of 5.0% and 10.0% w/v of PLX, while detecting upregulation of CDR1/CDR2 genes, indicative of drug efflux as the primary resistance mechanism. [Read the Full Post]

Optimization of anesthetic procedure in crustaceans: Evidence for sedative and analgesic-like effect of MS-222 using a semi-automated device for exposure to noxious stimulus

18 views | Feb 02 2024

This study demonstrates the efficacy of MS-222 as an anesthetic in Gammarus pulex while introducing a novel semi-automated electric shock device for assessing nociceptive responses in aquatic invertebrates, highlighting its potential for standardized research protocols in this field. [Read the Full Post]

C5 methylation confers accessibility, stability and selectivity to picrotoxinin

74 views | Feb 02 2024

Exploring minor modifications in picrotoxinin analogs revealed that a C5 methyl group significantly altered channel selectivity between mammalian and insect ion channels, pioneering the first systematic structure-activity relationship studies for picrotoxinin while highlighting the impact of subtle structural changes on functional properties. [Read the Full Post]

Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements

15 views | Feb 02 2024

The developed approach combining UV spectral deconvolution, HPLC, and microscale thermophoresis quantifies the KD for binding between active Ras and PI3K, revealing how specific Ras mutations at PI3K contact positions can significantly alter binding affinity and potentially impact cellular signaling and disease pathways. [Read the Full Post]

The Equilibria of Triterpene Sapogenins-Phosphatidylcholine in Monolayers at the Air/Water Interface

19 views | Feb 02 2024

The study investigating the interaction of asiatic acid and oleanolic acid with phosphatidylcholine (DPPC) in monolayers using the Langmuir method with Brewster angle microscopy revealed stable 1:1 complexes, shedding light on their potential applications and phase transitions within these systems. [Read the Full Post]

Antibody-decorated chitosan-iodoacetamide-coated nanocarriers for the potential delivery of doxorubicin to breast cancer cells

14 views | Feb 01 2024

Trastuzumab-conjugated chitosan iodoacetamide-coated nanocarriers loaded with doxorubicin demonstrate promising potential as a targeted and effective delivery system for HER-2-positive breast cancer, exhibiting superior antitumor activity and high cellular accumulation compared to unconjugated nanocarriers and drug solutions. [Read the Full Post]

Tauro-Urso-Deoxycholic Acid Trials in Amyotrophic Lateral Sclerosis: What is Achieved and What to Expect

23 views | Feb 01 2024

Phase II studies suggest the safety and efficacy of TUDCA in ALS treatment, with ongoing phase III trials expected to provide a more conclusive understanding of its potential. [Read the Full Post]

A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers

19 views | Feb 01 2024

The study's findings indicate that NTM-001, administered as a 12.5 mg IV bolus followed by continuous infusion, aligns closely with predicted pharmacokinetic parameters, demonstrating potential as a safe and effective nonopioid alternative for acute postoperative pain control. [Read the Full Post]

Role of MAPKs in TGF-β1-induced maturation and mineralization in human osteoblast-like cells

23 views | Feb 01 2024

"TGF-β1 induces mineralization in human osteoblast-like MG63 cells primarily through the activation of JNK within the MAPK signaling pathway." [Read the Full Post]

Unilateral hypoglossal nerve palsy following orthognathic surgery: A case report and literature review

12 views | Feb 01 2024

Unilateral hypoglossal nerve palsy following orthognathic surgery in a 56-year-old woman highlighted potential triggers like intubation, anesthesia-related factors, and viral infection, emphasizing the importance of clinicians' vigilance in recognizing and managing such postoperative complications. [Read the Full Post]