Blog of Signaling Pathways

PROTAC targeting cyclophilin A controls virus-induced cytokine storm

36 views | Jan 19 2024

Researchers have developed PROTACs targeting Cyclophilin A (CypA), showing promise in mitigating cytokine storms by reducing proinflammatory cytokine production and improving survival rates in influenza B virus-infected mice. [Read the Full Post]

Blocking SphK/S1P/S1PR1 axis signaling pathway alleviates remifentanil-induced hyperalgesia in rats

26 views | Jan 19 2024

This study demonstrates that blocking the SphK/S1P/S1PR1 axis mitigates remifentanil-induced hyperalgesia by reducing spinal cord inflammation and reactive oxygen species, offering potential avenues for managing opioid-induced pain sensitization. [Read the Full Post]

Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy

29 views | Jan 19 2024

The study highlights hsa_circRNA_0000585 as a potential therapeutic target to enhance cisplatin sensitivity in ovarian cancer, shedding light on overcoming chemoresistance in this context. [Read the Full Post]

Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction

25 views | Jan 19 2024

Ethanol-induced vascular dysfunction involves a cascade of events including RAAS activation, mitochondrial impairment, increased mtROS, reduced nitric oxide and hydrogen peroxide bioavailability, findings that offer potential therapeutic strategies for disorders linked to excessive ethanol consumption. [Read the Full Post]

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay

27 views | Jan 19 2024

The use of label-free dynamic mass redistribution assays revealed novel LPA1 inverse agonist CHI and highlighted the potential advantages over traditional calcium mobilization assays in characterizing LPA receptor ligands for diverse therapeutic applications. [Read the Full Post]

Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome

0 views | Jan 18 2024

This study utilizing transcriptome data and bioinformatic analysis identified common gene signatures across systemic autoimmune diseases, leading to the discovery of six potential small molecule drug candidates through drug repositioning, shedding light on novel therapeutic avenues for these conditions. [Read the Full Post]

Mitochondrial complex I inhibition by homoharringtonine: A novel strategy for suppression of chronic myeloid leukemia

23 views | Jan 18 2024

The rigorous evaluation of HHT's anti-CML effects, particularly its disruption of oxidative phosphorylation via mitochondrial complex I inhibition, unveils a promising therapeutic strategy to overcome resistance associated with the BCR-ABL T315I mutation. [Read the Full Post]

AT7867 promotes pancreatic progenitor differentiation of human iPSCs

50 views | Jan 18 2024

AT7867 treatment significantly enhances the differentiation of pancreatic progenitor cells, resulting in increased expression of key markers and accelerated diabetes reversal upon transplantation into diabetic mice. [Read the Full Post]

Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis

42 views | Jan 18 2024

The study highlights the potential of targeting the Skp2-Akt axis and utilizing gastrodin, inhibiting HK2-mediated glucose metabolism and promoting apoptosis, as a promising combined therapeutic approach for overcoming cisplatin resistance in oral squamous cell carcinoma (OSCC). [Read the Full Post]

Tetrahydrocannabinol (THC)-containing e-cigarette, or vaping, product use behaviors among adults after the onset of the 2019 outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI)

11 views | Jan 18 2024

This study reveals continued significant THC-EVP usage post-EVALI, emphasizing the need for ongoing monitoring and education to mitigate potential health risks associated with these products. [Read the Full Post]

CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth

36 views | Jan 17 2024

CYD0281, a newly discovered Bcl-2-BH4 antagonist, demonstrates remarkable potential as an anti-angiogenic therapy for breast cancer by inducing a conformational shift in Bcl-2, converting it into a pro-apoptotic molecule and inhibiting tumor growth. [Read the Full Post]

Physicochemical investigation and molecular docking analysis of Maha yogaraj Guggulu tablet and virtual screening of its major bioactive compound

19 views | Jan 17 2024

A computational study identified Guggulsterone isomers as potential high-affinity inhibitors of the Farnesoid X Receptor with promising cholesterol-lowering capabilities, while indicating concerns regarding their CYP3A4 inhibition and hepatotoxicity. [Read the Full Post]

JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells

35 views | Jan 17 2024

Fedratinib's combination with vincristine demonstrates promising cytotoxicity specifically in P-glycoprotein-overexpressing drug-resistant cancer cells, suggesting its potential as an effective co-treatment strategy for multidrug-resistant cancers. [Read the Full Post]

Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells

12 views | Jan 17 2024

The study reveals that Trx-1 mediates resistance to 2-deoxyglucose in colorectal cancer cells by upregulating SLC1A5, suggesting that targeting Trx-1 or SLC1A5 alongside glycolysis inhibition could offer a promising strategy for improving treatment efficacy. [Read the Full Post]

Management of erythropoietic protoporphyria with cholestatic liver disease: A case report

30 views | Jan 17 2024

Managing the complexities of Erythropoietic Protoporphyria (EPP), exacerbated by progressive cholestatic liver disease and further complicated by the coexistence of factor VII deficiency, necessitated a multifaceted approach culminating in successful allogeneic hematopoietic stem cell transplantation in this documented 3-year follow-up case. [Read the Full Post]

MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14

18 views | Jan 16 2024

The discovery of MitoCur-1's ability to inhibit USP14 and induce ferroptosis presents a promising avenue for reversing vemurafenib resistance in melanoma, potentially transforming treatment outcomes for patients. [Read the Full Post]

Reversible translocation of acyl-CoA:cholesterol acyltransferase (ACAT) between the endoplasmic reticulum and vesicular structures

26 views | Jan 16 2024

The dynamic translocation of ACAT from the endoplasmic reticulum to vesicular structures, triggered by diverse stimuli and inhibitors while maintaining its enzymatic activity, underscores the intricate regulatory mechanisms governing lipid metabolism in response to cellular cues. [Read the Full Post]

Lactate Dehydrogenase Gene Family in Spirometra mansoni (Cestoda: Diphyllobothriidea)-Phylogenetic Patterns and Molecular Characteristics

46 views | Jan 16 2024

This study on Spirometra mansoni identified 19 novel LDH members, delineated their expression patterns across developmental stages, characterized their structural features, enzymatic properties, and inhibition, providing fundamental insights into the diverse roles of LDHs in this parasite and related taxa. [Read the Full Post]

Effects of a novel direct-fed microbial on growth performance, carcass characteristics, nutrient digestibility, and ruminal morphology of beef feedlot steers

27 views | Jan 16 2024

The inclusion of L. salivarius L28 and monensin in finishing diets for steers did not significantly impact growth performance or ruminal fermentation but led to reduced feed intake and altered carcass quality, while also showing potential to positively influence ruminal morphology. [Read the Full Post]

Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition

21 views | Jan 16 2024

The innovative MOF@MOF structure, bolstering stability and effectively alleviating hypoxia in tumors via 7ACC2, represents a groundbreaking leap in enhancing photodynamic therapy, heralding a promising era for MOF-based nanomedicines. [Read the Full Post]