Blog of Signaling Pathways

Safety and efficacy of WC2031 versus vibramycin for the treatment of uncomplicated urogenital Chlamydia trachomatis infection: a randomized, double-blind, double-dummy, active-controlled, multicenter trial

113 views | Apr 23 2023

The study found that a once-daily, delayed-release formulation of doxycycline hyclate (WC2031) was noninferior to twice-daily Vibramycin for the treatment of uncomplicated urogenital chlamydia and was better tolerated, with comparable safety. [Read the Full Post]

Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure

103 views | Apr 23 2023

Fingolimod's inhibition of the NLRP3 inflammasome in a subset of MS patients may be responsible for their response to treatment, as evidenced by the differential effect of fingolimod on the formation of an ASC oligomer in monocytes between responders and nonresponders. [Read the Full Post]

Toxicity interactions of azole fungicide mixtures on Chlorella pyrenoidosa

190 views | Apr 23 2023

The study investigated the combined toxicities and toxic interactions of 225 binary mixtures and 126 multi-component mixtures of 10 azole fungicides on Chlorella pyrenoidosa, finding that the toxicity interactions at low concentrations are dominated by additive effects, while at high concentrations, both synergistic and antagonistic effects are observed, with epoxiconazole inducing synergistic effects and clotrimazole inducing antagonistic effects. [Read the Full Post]

The Chinese herbal prescription JieZe-1 inhibits caspase-1-dependent pyroptosis induced by herpes simplex virus-2 infection in vitro

56 views | Apr 23 2023

The study found that JieZe-1 (JZ-1) inhibits caspase-1-dependent pyroptosis induced by herpes simplex virus type 2 (HSV-2) infection and has excellent anti-HSV-2 activity in VK2/E6E7 cells. [Read the Full Post]

Fabricating transdermal film formulations of montelukast sodium with improved chemical stability and extended drug release

222 views | Apr 23 2023

This research developed a transdermal delivery system for Montelukast Sodium using SA and LS-based films as a controlled release drug delivery system, demonstrating the potential to improve bioavailability and providing a better mode of drug delivery for pediatric and elderly patients. [Read the Full Post]

Multifunctional porous poly (L-lactic acid) nanofiber membranes with enhanced anti-inflammation, angiogenesis and antibacterial properties for diabetic wound healing

237 views | Apr 22 2023

The study developed porous PLA/SCS/PDA-GS nanofiber membranes with enhanced antibacterial, anti-inflammatory, and angiogenic properties, demonstrating promising potential in diabetic wound healing processes. [Read the Full Post]

Assessing the risk of adverse pregnancy outcomes and birth defects reporting in women exposed to ganciclovir or valganciclovir during pregnancy: a pharmacovigilance study

178 views | Apr 22 2023

The analysis of VigiBase found no evidence of increased risk of adverse pregnancy outcomes or birth defects associated with the use of (val)ganciclovir compared to (val)aciclovir during pregnancy, with the exception of four cases of oesophageal and anorectal atresia that require further analysis. [Read the Full Post]

A Cardiologists' Survey on the Use of Anticoagulants and Antiplatelets in Patients With Atrial Fibrillation and Acute Coronary Syndrome or Those Undergoing Percutaneous Coronary Intervention in India

306 views | Apr 22 2023

The survey found that in India, the majority of cardiologists use triple therapy (NOAC + dual antiplatelet) or NOAC + single antiplatelet therapy to manage patients with AF and ACS or undergoing PCI, with NOACs being the preferred anticoagulant and ticagrelor and clopidogrel being the preferred P2Y12 inhibitors. [Read the Full Post]

Zearalenone induces mitochondria-associated endoplasmic reticulum membranes dysfunction in piglet Sertoli cells based on endoplasmic reticulum stress

169 views | Apr 22 2023

The study found that ZEA induces dysfunction of MAM in piglet SCs via the ERS pathway, and pretreatment with the ERS inhibitor 4-PBA can reduce ZEA-induced toxicity and regulate the expression of key proteins involved in MAM function. [Read the Full Post]

HBXIP blocks myosin-IIA assembly by phosphorylating and interacting with NMHC-IIA in breast cancer metastasis

135 views | Apr 22 2023

The study found that the oncoprotein HBXIP promotes breast cancer cell migration by blocking myosin-IIA assembly, and that the anti-hyperlipidemic drug bezafibrate (BZF) can inhibit PKCβII-mediated NMHC-IIA phosphorylation and suppress breast cancer metastasis both in vitro and in vivo. [Read the Full Post]

SARS-CoV-2 Main Protease Drug Design, Assay Development, and Drug Resistance Studies

213 views | Apr 21 2023

This Account describes efforts to develop covalent and noncovalent inhibitors of the SARS-CoV-2 main protease and the identification of nirmatrelvir-resistant mutants, providing guidance for the development of effective antivirals against COVID-19. [Read the Full Post]

Imaging the TGFβ type I receptor in pulmonary arterial hypertension

55 views | Apr 21 2023

This study evaluated the efficacy of two ALK5-targeting PET tracers for imaging ALK5 in pulmonary arterial hypertension, with [18F]EW-7197 showing superior in vivo imaging results compared to [11C]LR111. [Read the Full Post]

Adequacy of energy and macronutrients intake in differently active slovenian adolescents

499 views | Apr 21 2023

The study found that a significant proportion of Slovenian adolescents are not meeting national recommendations for energy and macronutrient intake, and there were differences in energy/macronutrient intake between boys of different physical activity levels, highlighting the need for interventions to encourage healthy eating and physical activity behaviors. [Read the Full Post]

Perinatal Stressors as a Factor in Impairments to Nervous System Development and Functions: Review of In Vivo Models

408 views | Apr 21 2023

This review evaluates different models of perinatal pathology and their relationship with psychoemotional stressors in understanding the impact of stress on the developing brain and behavior. [Read the Full Post]

Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity

140 views | Apr 21 2023

Sitagliptin shows promise as a potential antiglioma drug to overcome TMZ resistance and enhance the therapeutic efficacy of GBM treatment. [Read the Full Post]

An unconventional SNARE complex mediates exocytosis at the plasma membrane and vesicular fusion at the apical annuli in Toxoplasma gondii

101 views | Apr 20 2023

An unconventional SNARE complex comprising TgStx1, TgStx20, and TgStx21 mediates vesicular fusion at the plasma membrane in T. gondii, indicating a unique mechanism for exocytosis in this organism. [Read the Full Post]

PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales

248 views | Apr 20 2023

PPAR agonists are a promising new class of drugs for PBC treatment, especially for UDCA non-responders or intolerant patients, but further studies are needed to confirm their efficacy, safety, and long-term benefits. [Read the Full Post]

Budget impact analysis of two treatment approaches for hepatitis C in Malaysia through the use of voluntary and compulsory licensing options

92 views | Apr 20 2023

The study suggests that a stratified treatment cascade with SOF/VEL for cirrhotic patients and SOF/DAC for non-cirrhotic patients in Malaysia is a cost-saving approach. [Read the Full Post]

Safety and efficacy of elbasvir/grazoprevir in patients infected with hepatitis C virus genotype 4 in Qassim region of Saudi Arabia

80 views | Apr 20 2023

The study found that the elbasvir/grazoprevir (EBR-GZR) treatment regimen for 12 weeks is safe and effective in achieving sustained virological response (SVR12) in HCV genotype 4-infected treatment-naïve Saudi patients, with improvement in prognostic markers of liver disease in participants with compensated cirrhosis. [Read the Full Post]

Prebiotic Galacto-Oligosaccharides and Fructo-Oligosaccharides, but Not Acacia Gum, Increase Iron Absorption from a Single High-Dose Ferrous Fumarate Supplement in Iron-Depleted Women

61 views | Apr 20 2023

The study found that co-administration of prebiotic fibers such as GOS and FOS with FeFum increased iron absorption by approximately 50% in iron-depleted women, suggesting their potential as enhancers of supplemental iron absorption. [Read the Full Post]