Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- MELK
- PTEN
- PDPK1
- PP2A
- PIKfyve
- PI4K
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- Histone Acetyltransferase
- Epigenetic Reader Domain
- Histone Methyltransferase
- Histone Demethylase
- DNA Methyltransferase
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- NSD
- MLL
- FTO
- JMJD
- MicroRNA
- PRMT
- EZH1/2
- LSD1
- PAD
Methylation
- DNA Methyltransferase
- JMJD
- PRMT
- EZH1/2
- NSD
- LSD1
- FTO
- MAT2A
- NNMT
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
- COX
- CCR
- Histamine Receptor
- IL Receptor
- gp120/CD4
- IDO/TDO
- CXCR
- NOD
- MALT
- LTR
- TLR
- NOS
- Nrf2
- ROS
- NADPH-oxidase
- Anti-infection
- AhR
- Immunology & Inflammation related
- STING
- MIF
- Galectin
- Nur77
- Prostaglandin Receptor
- Complement System
- Glutathione
- SPHK
- β-lactamase
- PGES
- TBK1
- IFN
- IRAK
- FLAP
- Interleukins
- Arginase
- NLRP3
- Pyroptosis
- cGAS
- Neuraminidase
- SIK
- PGDS
- FKBP
- TRIF
- AKR1C
- PKR
- TpoR
- Parasite
- Heme Oxygenase
- MmpL3
- MyD88
- eIF
- Antioxidant
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- DYRK
- Ephrin receptor
- ACK
- CSF-1R
- Trk receptor
- BTK
- Axl
- Tyro3
- Pyk2
- ROS1
- DDR
- RON
- Fer kinase
- ETK/BMX
- Mertk
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- Myc
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
- PKD
- PFKFB
- FKBP
- cytohesin
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
- OGA
- Beclin
- LC3
- cGAS
ER stress & UPR
- JNK
- HSP (HSP90)
- ASK
- ROS
- PERK
- PDI
- IRE1
- eIF
- PKR
- Antioxidant
- ATF-6
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- Mixed Lineage Kinase
- MNK
- KLF
- TAK1
- ERK
- TOPK
- ASK
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- MPS1
- Dynamin
- PAK
- Integrin
- Gap-Junction
- MLCK
- Actin
- Cardiac Myosin
- PORCN
- TACC3
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- MPS1
- DYRK
- Casein Kinase
- PERK
- TOPK
- Serine/threonin kinase
- Myc
- PAK
- Rho
- FOXM1
- eIF
- Nur77
- TACC3
- PP2A
- RUNX
- PFKFB
- LIM kinase
- Mad2
- Haspin Kinase
- AP-1
- BMI-1
- Choline kinase
- p21
- DOCK
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- Pax
- FENs
- OGG1
- Thymidylate Synthase
- G-quadruplex
- RNR
- NUDIX
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- KLF
- OCT
- Casein Kinase
- ERK
- Stemness kinase
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- TEAD
- MAP4K
- MST
- YAP
- LATS
Ubiquitin
- Proteasome
- DUB
- SUMO
- E2 conjugating
- E3 Ligase
- p97
- E1 Activating
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- GlyT
- NMDAR
- CaMK
- BACE
- Trk receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- CCK receptor
- Serotonin Transporter
- COMT
- Neurotensin Receptor
- Melanocortin Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- ROS
- NOD
- MALT
- Nrf2
- Antioxidant
- AP-1
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- TAAR
- CaSR
- Glucagon Receptor
- LTR
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
- Neurotensin Receptor
- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- GRK
- Leukotriene
- FPR
- Prostaglandin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
- THR
- ACE
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
- MCT
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Thioredoxin
- Retinoid Receptor
- FXR
- Transferase
- CETP
- Serine/threonin kinase
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Decarboxylase
- Casein Kinase
- Leukotriene
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Acetyl-CoA carboxylase
- Adenosine Kinase
- OXPHOS
- Glutathione
- PCSK9
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PGDS
- Mitochondrial pyruvate carrier
- PREP
- Neprilysin
- PP2A
- FTO
- RUNX
- SREBP
- AdipoR
- PAD
- CPT
- SCD
- CAR
- AP-1
- LDH
- Carbohydrate Metabolism
- γGCS
- SSTR
- PAI-1
- FTase
- SOD
- ATP-citrate lyase
- FAO
- SGK
- GOT
- 3-MST
- GTPCH
- glucocerebrosidase
- FABP
- Serine hydrolase
- Epoxide Hydrolase
- ACSS2
- ROR
- Catalase
- THR
- Thioredoxin Reductase
- PDHK
- Glucosylceramide Synthase
- ACE
- Mannosidase
- PGC-1α
- PARG
- Xanthine Oxidase
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- Ribosomal Peptidyl Transferase
- Influenza Virus
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antiviral
- β-lactamase
- Bacterial
- 3C-Like Protease
- Antibiotics
- COVID-19
- Enterovirus
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Archives

Popular Post

ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Angiotensin Receptor

Evolving views on the first two ligands of the angiotensin II type 2 receptor. From putative antagonists to potential agonists?

262 views | Jan 08 2024

The evolving understanding of PD123319's effects challenges its traditional classification as an AT2 receptor antagonist, suggesting potential agonist-like actions at lower doses and highlighting the intricate balance between AT1 and AT2 receptor stimulation within the renin-angiotensin system. [Read the Full Post]

Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease

834 views | Feb 05 2022

Xingjian Zhang found that ARNI has application potential in DKD, but there still need clinical studies that focus on DKD patients to determine its effectiveness, safety and underlying mechanism. [Read the Full Post]

Hospitalization and Mortality in Patients With Heart Failure Treated With Sacubitril/Valsartan vs. Enalapril: A Real-World, Population-Based Study

1181 views | Feb 12 2021

Swathi Pathadka et al. found that in real-world settings, sacubitril/valsartan was associated with improved survival and reduced heart failure-related hospitalization compared to enalapril in Asian patients with heart failure. [Read the Full Post]