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ER stress & UPR
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Cytoskeletal Signaling
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Cell Cycle
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TGF-beta/Smad
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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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Hippo
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Ubiquitin
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Neuronal Signaling
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NF-κB
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GPCR & G Protein
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Endocrinology & Hormones
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Transmembrane Transporters
- CD markers
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- Mechanosensitive Channel
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Metabolism
- PPAR
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- HSP (HSP90)
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- Vitamin
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- Leukotriene
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- Adenosine Kinase
- OXPHOS
- SHIP
- PCSK9
- Mitochondrial Metabolism
- Peroxidases
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- PP2A
- Neprilysin
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- CAR
- AP-1
Proteases
- HDAC
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- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Cysteine Protease
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Neprilysin
- SGK
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- 3C-Like Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
- PGDS
Microbiology
- HCV Protease
- Integrase
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- HIV Protease
- Anti-infection
- CMV
- Neuraminidase
- Parasite
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- Antiviral
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Others
- ADC Cytotoxin
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- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

DYRK

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

281 views | Jan 09 2024

Targeting the stress-enhanced survival kinase DYRK1B alongside irradiation demonstrates a synergistic effect in eliminating colorectal tumor cells under harsh environmental stressors, offering a promising strategy to overcome treatment resistance. [Read the Full Post]

Active natural compounds perturb the melanoma risk-gene network

876 views | Jan 07 2024

The study ingeniously employs network modeling of melanoma-associated genes, revealing crucial pathways and potential therapeutic targets while showcasing the predictive potential of this model in evaluating the efficacy of anti-melanoma phytochemicals. [Read the Full Post]

Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity

1202 views | Nov 01 2018

Hutterer C et al. concluded that DYRK signaling represents a promising target pathway for the development of novel anti-herpesviral strategies. [Read the Full Post]

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

1320 views | Oct 31 2018

Singh R et al. showed that a pharmacological approach combining a DYRK1B antagonist with an mTOR/AKT inhibitor results in strong GLI1 targeting and in pronounced cytotoxicity in human pancreatic and ovarian cancer cells. [Read the Full Post]