Blog of Signaling Pathways

Bouwmeester, T., A. Bauch, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway." Nat Cell Biol 6(2): 97-105.

3613 views | Apr 20 2011

How the TNF-α triggers the NF-KB ? [Read the Full Post]

Bachmann, M. and T. Moroy (2005). "The serine/threonine kinase Pim-1." Int J Biochem Cell Biol 37(4): 726-730.

4930 views | Apr 16 2011

Pim-1 is able to phosphorylate different targets, most of which are involved in cell cycle progression or apoptosis. Pim-1 expression can be induced by several external stimuli in particular by a number of cytokines relevant in the immune system, which led to the labeling of Pim-1 as a "booster" for the immune response. [Read the Full Post]

Ren, R. (2005). "Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia." Nat Rev Cancer 5(3): 172-183.

4276 views | Apr 15 2011

The review which was published in Nature Review Cancer introduces the relationships between CML and BCR-ABL. The researchers introduce not only the BCR–ABL and oncogenic activities of BCR–ABL, roles of BCR–ABL domains in leukaemogenesis, but pathways downstream of BCR–ABL as well. [Read the Full Post]

Roux, P. P. and J. Blenis (2004). "ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions." Microbiol Mol Biol Rev 68(2): 320-344.

3216 views | Apr 9 2011

Give a introduction of physiological functions of ERK and P38 MAPK. [Read the Full Post]

Yardy, G. W. and S. F. Brewster (2005). "Wnt signalling and prostate cancer." Prostate Cancer Prostatic Dis 8(2): 119-126.

4829 views | Apr 8 2011

This article introduce the wnt pathway and the relationship between wnt and cancer. It really give athe detail information of wnt signal pathway. [Read the Full Post]

Yap, T. A., M. D. Garrett, et al. (2008). "Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises." Curr Opin Pharmacol 8(4): 393-412.

3406 views | Apr 4 2011

This review is about the drug discovery of cancer which is targeting the PI3K-AKT-mTOR pathway. Basic knowledge of the PI3K-AKT-mTOR pathway and anticancer therapeutics are both in this article. Anyone who is interested in drug discovery can benefit after reading this article. [Read the Full Post]

Tozer, G. M., C. Kanthou, et al. (2005). "Disrupting tumour blood vessels." Nat Rev Cancer 5(6): 423-435.

3493 views | Apr 3 2011

This article which is published in Nature Review Cancer not only reviews the basic information of VDAs, but provides many results about tumor cells which are treated with VDAs as well. [Read the Full Post]

Chen, G. and D. V. Goeddel (2002). "TNF-R1 signaling: a beautiful pathway." Science 296(5573): 1634-1635.

3856 views | Mar 26 2011

This short article introduce TNF-R1 signaling pathway and the targets which are regulated by TNF-R1 signaling pathway. [Read the Full Post]

Doble, B. W. and J. R. Woodgett (2003). "GSK-3: tricks of the trade for a multi-tasking kinase." J Cell Sci 116(Pt 7): 1175-1186.

4297 views | Mar 20 2011

This article introduces the insights of GSK-3 phosphorylation from crystal structures. It also introduces the role of GSK-3 in human disease, the role of GSK-3 in the Hedgehog pathway, the role of GSK-3 in the Wnt/beta-catenin pathway, GSK-3-binding proteins, GSK-3 substrates, and small molecule inhibitors of GSK-3. [Read the Full Post]

de Ruijter, A. J., A. H. van Gennip, et al. (2003). "Histone deacetylases (HDACs): characterization of the classical HDAC family." Biochem J 370(Pt 3): 737-749.

3993 views | Mar 20 2011

This is an article which give us the detail of HDAC family member proteins. It introduce the members of HDAC family one by one. You can make different HDACs clear after reading this article. [Read the Full Post]

Semenza, G. L. (2003). "Targeting HIF-1 for cancer therapy." Nat Rev Cancer 3(10): 721-732.

5399 views | Mar 19 2011

This article introduces the function of HIF-1, genes that are transcriptionally activated by HIF-1 and relationship between HIF-alpha and cancer. It also introduces HIF-1 targeted therapeutics. [Read the Full Post]

Lane, D. P. and T. R. Hupp (2003). "Drug discovery and p53." Drug Discov Today 8(8): 347-355.

3442 views | Mar 19 2011

The article try to explain the relationship between p53 structure and drug discovery of p53. [Read the Full Post]

Hagemann, C. and J. L. Blank (2001). "The ups and downs of MEK kinase interactions." Cell Signal 13(12): 863-875.

2727 views | Mar 18 2011

A review focus on MEK. This review summarises the upstream and downstream of MEK. It give a detail introduction of the targets which interact with MEK. [Read the Full Post]

Nelson, J., A. Bagnato, et al. (2003). "The endothelin axis: emerging role in cancer." Nat Rev Cancer 3(2): 110-116.

3337 views | Mar 17 2011

The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation. [Read the Full Post]

Gilliland, D. G. and J. D. Griffin (2002). "The roles of FLT3 in hematopoiesis and leukemia." Blood 100(5): 1532-1542.

4431 views | Mar 14 2011

This review provides comprehensive coverage of the role that FLT3 in hematopoiesis and leukemia and how the FLT-3 inhibitors work in treatment of hematopoiesis and leukemia. [Read the Full Post]

Coultas, L. and A. Strasser (2003). "The role of the Bcl-2 protein family in cancer." Semin Cancer Biol 13(2): 115-123.

2722 views | Mar 11 2011

A review which gives a systematic description of the relationship between bcl-2 and cancer. [Read the Full Post]

Fischer, O. M., S. Hart, et al. (2003). "EGFR signal transactivation in cancer cells." Biochem Soc Trans 31(Pt 6): 1203-1208.

3639 views | Mar 11 2011

Together with investigations revealing the importance of this GPCR-EGFR cross-talk mechanism in cardiac hypertrophy, Helicobacter pylori -induced pathophysiological processes and cystic fibrosis, these findings support an important role for GPCR ligand-dependent EGFR signal transactivation in diverse pathophysiological disorders. [Read the Full Post]

Davis, R. J. (2000). "Signal transduction by the JNK group of MAP kinases." Cell 103(2): 239-252.

4418 views | Mar 9 2011

This is an classic review which introduce role of the JNK Signaling Pathway in MAPKKK pathway, cell survival and apoptosis. [Read the Full Post]

Riento, K. and A. J. Ridley (2003). "Rocks: multifunctional kinases in cell behaviour." Nat Rev Mol Cell Biol 4(6): 446-456.

4906 views | Mar 3 2011

This article introduces regulation of ROCK activity, ROCK function and ROCK inhibitors. This review concludes knowledge of ROCK in different ways. [Read the Full Post]

Adams, J. M. and S. Cory (1998). "The Bcl-2 protein family: arbiters of cell survival." Science 281(5381): 1322-1326.

2557 views | Mar 2 2011

A article about bcl-2 family proteins which is citied more than 3500.One of the most classical articles about bcl-2 family proteins which is published in science. [Read the Full Post]