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Archives
GSK-3
Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype
4 views | Mar 15 2021
Kamesh Dhamodaran et al. found that, in normal hTM cells, activation of the Wnt pathway reversed the pathological phenotype caused by Wnt inhibition and might thus be a viable therapeutic for lowering IOP. [Read the Full Post]
Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor
7 views | Feb 17 2021
Sean D Allen et al. provided proof-of-principal demonstration of the feasibility of using encapsulated delivery of a GSK3 inhibitor to provide cancer immunotherapy, with the possibility to be used as a monotherapy or in combination with chemotherapy or other immunomodulatory agents. [Read the Full Post]
The apoptotic effect of GSK-3 inhibitors: BIO and CHIR 98014 on H1975 lung cancer cells through ROS generation and mitochondrial dysfunction
10 views | Feb 07 2021
Theodore Lemuel Mathuram et al. found that the use of GSK-3 inhibitors showed promising apoptotic abilities in clinical cancer treatments, particularly for lung cancer cells. [Read the Full Post]
Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
16 views | Jan 07 2021
Chunlong Ma et al. suggested that these six compounds were nonspecific SARS-CoV-2 Mpro inhibitors and urged the scientific community to be stringent with hit validation. [Read the Full Post]
Generation of Liver Bipotential Organoids With a Small-Molecule Cocktail
172 views | Jun 05 2020
Xin Wang et al. demonstrated that Wnt/β-catenin, NMII-Rac, and PKA-ERK are core signaling pathways essential and sufficient for mouse liver progenitor expansion. [Read the Full Post]
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion
116 views | May 18 2020
Zhao WN et al. not only provided insights into the neural substrates regulated by lithium, but also provided novel human neuronal assays for supporting the development of mechanism-based therapeutics for BD and related neuropsychiatric disorders. [Read the Full Post]
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis
132 views | May 07 2020
Zheng YW et al. found that FAM83A promotes the proliferation and invasion of lung cancer cells by regulating the Wnt and Hippo signaling pathways and EMT process. [Read the Full Post]
GSK-3 Inhibitors: A Double-Edged Sword? - An Update on Tideglusib
148 views | May 05 2020
Mathuram TL et al. concluded the emergence of GSK-3 inhibitors as a 'double-edged sword' in the treatment against human diseases cautioning researchers about the potential ramifications of off-target pharmacological effects. [Read the Full Post]
Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures
248 views | Nov 27 2019
Aoki H et al. improved regenerative medicine and facilitate basic studies on the endothelial lineage. [Read the Full Post]
Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
237 views | Nov 27 2019
Xu J et al. demonstrated that stable iPS cells could be generated in LCDM medium, which could give rise to both embryonic and extraembryonic cells in vivo. However, the efficiency and level of chimeric contribution of pig LCDM-iPS cells were found low. [Read the Full Post]
