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Integrin

FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer

12 views | Mar 24 2021

Takuro Hirano et al. suggested that the integrin αvβ5-FARP1-CDC42 axis played a crucial role in gastric cancer cell migration and invasion. [Read the Full Post]

The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary Fibrosis : Cilengitide and Bleomycin-Induced Pulmonary Fibrosis

18 views | Jan 05 2021

Jeffrey D Ritzenthaler et al. suggested that, despite its in vitro activity in fibroblasts, daily injections of cilengitide (20 mg/kg) did not inhibit the development of or ameliorate bleomycin-induced pulmonary fibrosis in mice. [Read the Full Post]

Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins

719 views | Feb 11 2018

Zustiak SP et al. indicated that both 3D matrix stiffness and cell-matrix adhesions are important parameters in the design of more predictive in vitro platforms for drug development and toxicity screening. [Read the Full Post]

Antagonizing Integrin β3 Increases Immunosuppression in Cancer

793 views | Oct 13 2017

Su X et al. suggest that effects of integrin β3 therapies on immune cells should be considered to improve outcomes. [Read the Full Post]

Integrin αvβ1 Modulation Affects Subtype B Avian Metapneumovirus Fusion Protein-mediated Cell-Cell Fusion and Virus Infection

1047 views | Feb 09 2017

Yun B, et al. suggested that integrin αvβ1 is a functional receptor for aMPV/B F protein-mediated membrane fusion and virus infection, which will provide new insights on the fusogenic mechanism and pathogenesis of aMPV. [Read the Full Post]

Antagonizing Integrin β3 Increases Immunosuppression in Cancer

1348 views | Nov 15 2016

Su X et al. suggested that effects of integrin β3 therapies on immune cells should be considered to improve outcomes. [Read the Full Post]

Integrin αvβ1 Modulation Affects Subtype B Avian Metapneumovirus Fusion Protein-mediated Cell-Cell Fusion and Virus Infection

1294 views | Nov 02 2016

Yun B et al. suggested that integrin αvβ1 is a functional receptor for aMPV/B F protein-mediated membrane fusion and virus infection, which will provide new insights on the fusogenic mechanism and pathogenesis of aMPV. [Read the Full Post]