COX

Protective Role of Ethanol Extract of Cibotium barometz (Cibotium Rhizome) against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes

26 views | Feb 14 2024

This study demonstrates the potential of Cibotium Rhizome extract (ECR) in mitigating dexamethasone-induced muscle atrophy by modulating key proteins involved in muscle growth and atrophy pathways in C2C12 myotubes, offering a promising avenue for developing therapeutic agents against conditions like sarcopenia. [Read the Full Post]

A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers

19 views | Feb 01 2024

The study's findings indicate that NTM-001, administered as a 12.5 mg IV bolus followed by continuous infusion, aligns closely with predicted pharmacokinetic parameters, demonstrating potential as a safe and effective nonopioid alternative for acute postoperative pain control. [Read the Full Post]

The protective effects of NE 52-QQ57 against interleukin-33-induced inflammatory response in activated synovial mast cells

68 views | Oct 09 2023

The study suggests that inhibiting GPR4 signaling with the antagonist NE 52-QQ57 may have therapeutic benefits in rheumatoid arthritis by reducing inflammatory responses and oxidative stress in synovial mast cells. [Read the Full Post]

Association of reported NSAID adverse drug reactions with opioid prescribing following total joint arthroplasty

96 views | Apr 14 2023

This retrospective cohort study found that reported adverse drug reactions to nonsteroidal anti-inflammatory drugs were associated with an increased risk of prolonged receipt of opioids following total joint arthroplasty. [Read the Full Post]

Mechanisms of paeoniaceae action as an antidepressant

44 views | Mar 22 2023

Paeoniflorin (PF) has been shown to have multiple mechanisms through which it exerts its antidepressant effects, including increasing the levels of monoamine neurotransmitters, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of BDNF. [Read the Full Post]

Electrochemically assisted production of biogenic palladium nanoparticles for the catalytic removal of micropollutants in wastewater treatment plants effluent

35 views | Mar 11 2023

This work demonstrates the potential of biogenic palladium nanoparticles to remove persistent micropollutants from wastewater, with the size of the nanoparticles affecting their catalytic activity. [Read the Full Post]

Electrospun nanofibers using β-cyclodextrin grafted chitosan macromolecules loaded with indomethacin as an innovative drug delivery system

30 views | Mar 06 2023

The study developed a β-CD-g-CS nanofiber-based drug delivery system with sustained release of indomethacin and favorable physicomechanical properties and biocompatibility for use in orthopedic applications. [Read the Full Post]

Solvent-Mediated Tunable Regiodivergent C6- and N1-Alkylations of 2,3-Disubstituted Indoles with p-Quinone Methides

53 views | Mar 06 2023

A new method for regioselective alkylations of 2,3-disubstituted indoles with para-quinone methides using indium catalysts and solvents has been developed and can be selectively adjusted, scaled up, and applied to the late-stage functionalization of indomethacin with support from experimental and density functional theory studies. [Read the Full Post]

Current therapeutic modalities and chemopreventive role of natural products in liver cancer: Progress and promise

215 views | Feb 19 2023

Liver cancer treatment options depend on the progression stage of the disease and may include surgery, ablation and radiotherapy, first-line drugs and immunotherapy, and second-line chemotherapeutic drugs, while natural compounds like resveratrol, curcumin and diallyl sulfide are emerging as promising anticancer agents to manage liver cancer. [Read the Full Post]

Overview of Cochrane Systematic Reviews of rehabilitation interventions for persons with rheumatoid arthritis: a mapping synthesis

56 views | Feb 13 2023

This paper provides an overview of Cochrane Systematic Reviews on the effectiveness of rehabilitation interventions for rheumatoid arthritis, including physical activity and exercises, psychosocial interventions, and pharmacological agents, with physical activity and exercises being effective for some outcomes and pharmacological agent celecoxib having similar pain relief effects with fewer adverse events compared to traditional NSAIDs, but inconclusive results for some interventions due to low quality of evidence. [Read the Full Post]