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Hydroxylase

Lack of zinc finger protein 521 upregulates dopamine β-hydroxylase expression in the mouse brain, leading to abnormal behavior

7 views | Dec 10 2020

Nobutaka Ohkubo et al. suggested that the lack of ZFP521 upregulated the expression of DBH, which led to a decrease in the DA level and an increase in the NA level in the brain, resulting in abnormal behaviors. [Read the Full Post]

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

173 views | Mar 04 2020

De La Garza R 2nd et al. indicated that nepicastat is safe when co-administered with cocaine and may suppress its positive subjective effects, and may be viable as a pharmacotherapy for treatment of cocaine use disorder. [Read the Full Post]