Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice

33 views | Mar 10 2022

Leticia Gil de Biedma-Elduayen et al. demonstrated that the modulation of the kynurenine pathway was an effective strategy for the treatment of ethanol dependence in both sexes. [Read the Full Post]

Treatment With Nepicastat Decreases Contextual Traumatic Memories Persistence in Post-traumatic Stress Disorder

116 views | Nov 28 2021

Raquel Martinho wt al. found that the increase in Npas4 and Bdnf mRNA expression in the hippocampus might be important to develop a weaker traumatic contextual memory after nepicastat treatment. [Read the Full Post]

Addiction and the kynurenine pathway: A new dancing couple?

205 views | Mar 23 2021

Nuria Morales-Puerto et al. discussed ethanol, nicotine, cannabis, amphetamines, cocaine and opioids and new prospects in the drug research field were proposed [Read the Full Post]

Lack of zinc finger protein 521 upregulates dopamine β-hydroxylase expression in the mouse brain, leading to abnormal behavior

195 views | Dec 10 2020

Nobutaka Ohkubo et al. suggested that the lack of ZFP521 upregulated the expression of DBH, which led to a decrease in the DA level and an increase in the NA level in the brain, resulting in abnormal behaviors. [Read the Full Post]

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

618 views | Mar 04 2020

De La Garza R 2nd et al. indicated that nepicastat is safe when co-administered with cocaine and may suppress its positive subjective effects, and may be viable as a pharmacotherapy for treatment of cocaine use disorder. [Read the Full Post]