Blog of Signaling Pathways

Solvent-Mediated Tunable Regiodivergent C6- and N1-Alkylations of 2,3-Disubstituted Indoles with p-Quinone Methides

53 views | Mar 06 2023

A new method for regioselective alkylations of 2,3-disubstituted indoles with para-quinone methides using indium catalysts and solvents has been developed and can be selectively adjusted, scaled up, and applied to the late-stage functionalization of indomethacin with support from experimental and density functional theory studies. [Read the Full Post]

Electrospun nanofibers using β-cyclodextrin grafted chitosan macromolecules loaded with indomethacin as an innovative drug delivery system

30 views | Mar 06 2023

The study developed a β-CD-g-CS nanofiber-based drug delivery system with sustained release of indomethacin and favorable physicomechanical properties and biocompatibility for use in orthopedic applications. [Read the Full Post]

Effect of double-dose levonorgestrel subdermal implant in women taking efavirenz-based antiretroviral therapy: The DoubLNG pharmacokinetic study

31 views | Mar 06 2023

The study found that double-dose LNG implants did not fully overcome drug-drug interactions with efavirenz-based ART in women with HIV, and alternative ART without drug-drug interactions should be used with contraceptive implants. [Read the Full Post]

IgG4 related pericardium and lung disease in pediatric patient complicated with fatal massive hemoptysis: a case report and review of literature

48 views | Mar 06 2023

This case highlights the rarity and severity of pericardio-pulmonary involvement in pediatric IgG4-RD and the potential risks associated with the use of rituximab as a rescue therapy. [Read the Full Post]

A case of systemic lupus erythematosus having concurrent Evans syndrome and acquired thrombotic thrombocytopenic purpura

30 views | Mar 06 2023

TTP in patients with refractory immune-mediated thrombocytopenia and atypical symptoms. [Read the Full Post]

Predict the Effects of Dolutegravir (DTG) Plus Lamivudine (3TC) on Immunological Responses in People Living with HIV (PLWHIV)

28 views | Mar 05 2023

The study identified factors that limit or enhance immune recovery in PLWHIV after switching to DTG plus 3TC and may help clinicians predict treatment effects on immunological responses before the switch. [Read the Full Post]

Long-term clinical, immunologic, and virologic outcomes among early-treated children with HIV in Botswana: a nonrandomized controlled clinical trial

24 views | Mar 05 2023

The Early Infant Treatment Study in Botswana found that initiating antiretroviral treatment in the first week of life led to positive clinical outcomes and low viral reservoir through 96 weeks, with pre-ART reservoir size at birth predicting the viral reservoir at 84/96 weeks. [Read the Full Post]

Bioactive compounds from four Indian medicinal plants have different potency to induce sex reversal in Nile tilapia: A chromatographic, molecular docking and in silico analysis

57 views | Mar 05 2023

The study evaluated the anti-aromatase activity of four plant extracts, identified androgenic bioactive compounds, and determined their potential for masculinization in Nile tilapia, with Tribulus terrestris and Asparagus racemosus extracts showing the greatest potency and 2,4-bis(1,1-dimethylethyl) phenol being identified as a potential compound for masculinization through dietary administration. [Read the Full Post]

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

57 views | Mar 05 2023

The study investigated hOAT1 transport function, modulation of activity, and transport dysfunctions arising from mutations using molecular dynamics simulations and proposed a structural rationalization of the observations. [Read the Full Post]

Efficacy of nucleos(t)ide analogues(NAs) in preventing virus reactivation in oncology patients with HBV infection after chemotherapy or surgery: A network meta-analysis

28 views | Mar 05 2023

This study used a network meta-analysis to compare the effectiveness of different NAs in reducing reactivation of HBV, chemotherapy disruption, and improving survival in oncology patients with HBV, finding that lamivudine and entecavir were effective in prolonging survival, while tenofovir was best for reducing chemotherapy disruption. [Read the Full Post]

Cotton swabs decorated with Ag@BPQD for the fluorescence determination of 3-aminosalicylic and 5-aminosalicylic acid

37 views | Mar 04 2023

A portable cotton swab-based fluorometry using silver-doped black phosphorus quantum dots was developed for detecting 3-aminosalicylic acid and 5-aminosalicylic acid in environmental and biological samples with high efficiency, accuracy, and portability. [Read the Full Post]

Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis

28 views | Mar 04 2023

The study found that Fludarabine/busulfan is the optimal conditioning regimen for allogeneic hematopoietic cell transplantation in myelofibrosis based on lower mortality and graft versus host disease rates. [Read the Full Post]

Effect of maca (Lepidium meyenii) extract on non-obstructive azoospermia in male mice

44 views | Mar 04 2023

The study found that maca can improve azoospermia by promoting testicular recovery and increasing testosterone levels, with the polysaccharide fraction identified as the active component. [Read the Full Post]

Transport of hydrocortisone in targeted layers of the skin by multi-lamellar liposomes

12 views | Mar 04 2023

Encapsulation of hydrocortisone in multi-lamellar liposomes enabled targeted delivery to different skin layers with non-Fickian diffusion observed for formulations targeting the stratum corneum and living epidermis. [Read the Full Post]

A Novel Mutation in Melanocortin Receptor 2 and a Reported Mutation in Melanocortin Receptor 2 Accessory Protein: Three Chinese Cases with Familial Glucocorticoid Deficiency

14 views | Mar 04 2023

This report describes three Chinese patients with familial glucocorticoid deficiency, their different clinical presentations, and the importance of genetic testing for accurate diagnosis and appropriate treatment. [Read the Full Post]

Antifibrinolytics use during surgery for oncological spine diseases: A systematic review

36 views | Mar 03 2023

The use of tranexamic acid in patients undergoing surgery for oncological spine disease may reduce intraoperative blood loss, transfusion requirements, and postoperative drainage while not significantly increasing the incidence of deep venous thrombosis or pulmonary embolism. [Read the Full Post]

First report of rot disease in Prunus salicina var. taoxingli fruit caused by Fusarium lateritium in China

0 views | Mar 03 2023

A study reports on Fusarium lateritium causing rot on Shengzhou nane fruits in Zhejiang province, China, and highlights the need for effective control strategies to reduce its incidence. [Read the Full Post]

Effect of Disulfiram on the Reproductive Capacity of Female Mice

80 views | Mar 03 2023

Disulfiram (DSF) has been found to increase ovulation rate, enhance antioxidant capacity of oocytes, and promote successful pregnancy in mice by regulating gene expression related to angiogenesis, follicular development, ovulation, and antioxidants, however, more research is needed to determine if these results can be translated to humans and the safety of using DSF during pregnancy. [Read the Full Post]

Medications for the Treatment of Alcohol Dependence-Current State of Knowledge and Future Perspectives from a Public Health Perspective

112 views | Mar 03 2023

The treatment of alcohol dependence requires a multi-disciplinary approach, combining psychotherapy with medications, and more research is needed to find new and effective treatments for this complex condition. [Read the Full Post]

A Rare Case of Pseudomembrane-Associated Ulcerative Colitis

74 views | Mar 03 2023

A 43-year-old female with chronic bloody diarrhea initially evaluated for CDI was found to have pseudomembranous colitis on endoscopic evaluation, but subsequent findings were consistent with a diagnosis of ulcerative colitis. [Read the Full Post]