Blog of Signaling Pathways

Preliminary In Vitro and In Vivo Insights of In Silico Candidate Repurposed Drugs for Alzheimer's Disease

12 views | Jan 15 2024

Your study on repurposed drugs for Alzheimer's disease highlights promising candidates like clomiphene citrate and Pik-90, signaling a step forward in bridging computational predictions with experimental validation. [Read the Full Post]

High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis

18 views | Jan 15 2024

Short-term exposure to high radiofrequency exacerbates myocardial ischemia/reperfusion injury by upregulating calcium-sensing receptors, leading to increased cytosolic calcium levels, ROS production, and subsequent activation of the NLRP3 inflammasome, ultimately promoting pyroptotic cell death. [Read the Full Post]

Astaxanthin: A Marine Drug That Ameliorates Cerebrovascular-Damage-Associated Alzheimer's Disease in a Zebrafish Model via the Inhibition of Matrix Metalloprotease-13

15 views | Jan 15 2024

This study suggests that astaxanthin may offer promise in mitigating Alzheimer's disease-related cognitive and biochemical changes in zebrafish by inhibiting MMP-13 activity, potentially indicating a multi-targeted therapeutic approach for AD management. [Read the Full Post]

Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly

32 views | Jan 15 2024

Leukadherin-1 (LA-1) demonstrates potent inhibition of NLRP3 inflammasome activation through specific mechanisms, suggesting its potential as a targeted treatment for NLRP3-associated inflammatory diseases. [Read the Full Post]

Preclinical Characterization of XL092, a Novel Receptor Tyrosine Kinase Inhibitor of MET, VEGFR2, AXL, and MER

43 views | Jan 15 2024

XL092, a multi-receptor tyrosine kinase inhibitor, exhibits potent antitumor effects and immunomodulatory properties in preclinical models, supporting its potential for clinical evaluation, particularly in combination with immune checkpoint inhibitors. [Read the Full Post]

PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

35 views | Jan 14 2024

PP121, a dual tyrosine and phosphoinositide kinase inhibitor, demonstrates promising anti-contractile and anti-inflammatory effects in asthma treatment, suggesting its potential as a novel therapeutic compound for managing the condition. [Read the Full Post]

Immunotherapies against HER2-Positive Breast Cancer

21 views | Jan 14 2024

Immunotherapy offers a promising array of strategies, from cancer vaccines to immune checkpoint blockade and adoptive cell therapy, holding the potential to transform the treatment landscape for HER2-positive breast cancer by enhancing immune responses and potentially preventing disease progression. [Read the Full Post]

Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells

26 views | Jan 14 2024

This study highlights that the combined inhibition of DDR1, integrin αVβ3, and integrin αVβ5 effectively diminishes radioresistance in human glioblastoma cells by disrupting clonogenicity, enhancing cellular radiosensitivity, and impeding DNA repair mechanisms. [Read the Full Post]

pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function

23 views | Jan 14 2024

The study investigates the pH-dependent behavior of distinct ionizable lipids within lipid nanoparticles used for mRNA delivery, revealing structural transitions in CIL/cholesterol bulk phases that correlate with differences in mRNA delivery efficacy, shedding light on their varying effectiveness in gene expression. [Read the Full Post]

Targeting exon 20 insertion mutations in lung cancer

37 views | Jan 14 2024

Recent clinical evidence suggests that targeted therapies like mobocertinib and amivantamab offer promising antitumor activity for patients with EGFR exon 20 insertions in non-small cell lung cancer, while ongoing trials with novel treatments such as DZD9008 and CLN-081 hold potential for further improving survival outcomes in this challenging subset of patients. [Read the Full Post]

Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics

25 views | Jan 13 2024

The study demonstrates that ORP3, highly expressed in healthy bladder epithelium but downregulated in invasive bladder cancer, serves as a crucial tumor suppressor by influencing aneuploidy, genomic stability, and metastatic characteristics through its interactions with cytoskeletal components, elucidating a pivotal molecular link between aneuploidy and the invasive properties of metastatic cells. [Read the Full Post]

Lyophilization enhances the stability of Panax notoginseng total saponins-loaded transfersomes without adverse effects on ex vivo/in vivo skin permeation

47 views | Jan 13 2024

Lyophilized Panax notoginseng saponin-loaded transfersomes (PNS-FD-TFSs) exhibit enhanced stability while preserving transdermal absorption, offering a promising advancement in drug delivery systems. [Read the Full Post]

The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC

28 views | Jan 13 2024

The study demonstrates the synergistic potential of combining recombinant methioninase (rMETase) and ethionine to selectively eradicate osteosarcoma cells while down-regulating c-MYC expression, highlighting a promising avenue for future clinical strategies against this form of cancer. [Read the Full Post]

GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPARβ/δ/CD300a/SHP1 pathway after GMH in neonatal rats

31 views | Jan 13 2024

The study presents compelling evidence that GW0742, a PPARβ/δ agonist, attenuates mast cell-induced inflammation post-germinal matrix hemorrhage (GMH) by activating the CD300a/SHP1 pathway, offering a promising avenue for mitigating brain injury in GMH patients. [Read the Full Post]

Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter Pylori: Computer-aided Design and in vitro Confirmation

20 views | Jan 13 2024

Clodronic acid's robust inhibition of Helicobacter pylori urease, supported by computational screening and in vitro assays, positions it as a promising candidate for repurposing into an efficient drug against H. pylori infection. [Read the Full Post]

A Novel Polyamino Acid Sulfur Dioxide Prodrug Synergistically Elevates ROS with β-lapachone in Cancer Treatment

28 views | Jan 12 2024

This groundbreaking study combines sulfur dioxide gas therapy and a specific ROS-inducing agent, β-lapachone, encapsulated in nanoparticles, demonstrating potent anticancer effects through oxidative stress induction in both in vitro and in vivo models. [Read the Full Post]

LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells

17 views | Jan 12 2024

Rotatenone-induced LRRK2 upregulation triggers cellular senescence, promoting α-synuclein accumulation in Parkinson's disease, which can be mitigated by LRRK2 kinase inhibition, suggesting a potential therapeutic avenue for disease intervention. [Read the Full Post]

[99mTc]Tc-HYNIC-RM2: A potential SPECT probe targeting GRPR expression in prostate cancers

28 views | Jan 12 2024

The study successfully synthesized and evaluated the 99mTc-labeled HYNIC-RM2 probe, demonstrating high affinity, metabolic stability, enhanced tumor uptake, and clear visualization of GRPR-positive prostate cancer tumors via SPECT imaging, affirming its potential as a promising agent for further exploration in targeting GRPR. [Read the Full Post]

Network pharmacology integrated with molecular docking technology to reveal the potential mechanism of Shuganfang against drug-induced liver injury

26 views | Jan 12 2024

The comprehensive study on Shuganfang's mechanism in treating drug-induced liver injury through network pharmacology and molecular docking revealed multiple active ingredients, core targets, and pathways, establishing a solid foundation for its potential as a therapeutic option. [Read the Full Post]

Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats

26 views | Jan 12 2024

Granule Dendrobii (GD) demonstrated efficacy in ameliorating chronic atrophic gastritis (CAG) in rats by improving gastric mucosal pathology and modulating the abundance of specific bacteria like Lactobacillus and Turicibacter, suggesting its potential as a treatment and offering new insights into CAG-associated microbiota. [Read the Full Post]