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Methylation
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Immunology & Inflammation
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Protein Tyrosine Kinase
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Angiogenesis
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Autophagy
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ER stress & UPR
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JAK/STAT
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MAPK
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Cytoskeletal Signaling
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Cell Cycle
- CDK
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TGF-beta/Smad
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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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- PKA
- OCT
- Casein Kinase
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- Notch
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Hippo
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Ubiquitin
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- p97
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Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
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- Adrenergic Receptor
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- MT Receptor
- MAO
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- GlyT
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- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
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- COMT
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- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
NF-κB
- HDAC
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- MALT
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GPCR & G Protein
- Ras
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- CCR
- GluR
- Adrenergic Receptor
- AChR
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- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- LTR
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- TAAR
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- Glucagon Receptor
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- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
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- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- GPCR19
- AdipoR
- Guanylate Cyclase
- GHSR
- CCK receptor
- FPR
- GRK
- Leukotriene
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- CCK receptor
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- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
- MCT
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- GLUT
- phosphatase
- HMG-CoA Reductase
- Vitamin
- Lipoxygenase
- PKM
- Lipase
- FOX
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- Mitochondrial pyruvate carrier
- PREP
- PGDS
- PP2A
- Neprilysin
- RUNX
- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- LDH
- Carbohydrate Metabolism
- CAR
- AP-1
- PAI-1
- γGCS
- SSTR
- FAO
- FTase
- SOD
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- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- ACE
- Thioredoxin Reductase
- PDHK
- Glucosylceramide Synthase
- Xanthine Oxidase
- Mannosidase
- PGC-1α
- PARG
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Deaminase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Adenosine Kinase
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial Metabolism
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Serine Protease
- Cysteine Protease
- MALT
- Glutaminase
- Tyrosinase
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- GOT
- PREP
- 3C-Like Protease
- PCSK9
- PAD
- Secretase
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HPV
- HSV
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Antiviral
- Thioredoxin Reductase
- Bacterial
- β-lactamase
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Liver X Receptor

Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals

89 views | Jan 11 2022

Clémentine Garoche et al. demonstrated the importance of the use of species-specific models to study endocrine and metabolism disruption by environmental chemicals. [Read the Full Post]

Regulation of cytochrome P450 4F11 expression by liver X receptor alpha

253 views | Jan 21 2021

Tao Zhang et al. found that the regulation of CYP4F11 might contribute to the anti-inflammatory activity of LXRα agonists. [Read the Full Post]

Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury

0 views | Feb 12 2019

Wang Z et al. indicated that upregulation of SULT2B1b might promote HOC proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury. [Read the Full Post]

The LXR ligand GW3965 inhibits Newcastle disease virus infection by affecting cholesterol homeostasis

670 views | Sep 13 2018

Sheng XX et al. suggested that GW3965 inhibits NDV infection, probably by affecting cholesterol homeostasis. [Read the Full Post]

ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells

713 views | Jul 16 2018

Huang X et al. identified anti-ICAM-T0901317 liposomes as a promising nanotherapeutic approach to overcome VSMC proliferation during atherosclerosis progression. [Read the Full Post]