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PI3K/Akt/mTOR
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Epigenetics
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Methylation
- DNA Methyltransferase
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Immunology & Inflammation
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Protein Tyrosine Kinase
- VEGFR
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Angiogenesis
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Apoptosis
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- RIP kinase
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- OXPHOS
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- TRADD
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- Thymidylate Synthase
- Pyroptosis
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Autophagy
- Autophagy
- Nrf2
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- FKBP
- LC3
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- Mitophagy
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ER stress & UPR
- JNK
- HSP (HSP90)
- PERK
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JAK/STAT
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MAPK
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Cytoskeletal Signaling
- Akt
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- Integrin
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Cell Cycle
- CDK
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- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
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- Microtubule Associated
- DHFR
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- Wee1
- Rho
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- PERK
- MPS1
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- Casein Kinase
- DYRK
- Myc
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TGF-beta/Smad
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DNA Damage/DNA Repair
- HDAC
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- DNA/RNA Synthesis
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- High-mobility Group
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- Nucleoside Analog/Antimetabolite
- LIM kinase
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- FENs
- BMI-1
- Pax
- OGG1
- Thymidylate Synthase
- eIF
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Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Gamma-secretase
- Hedgehog/Smoothened
- PKA
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- Casein Kinase
- SFRP
- Fascin
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- Notch
Hippo
- YAP
- TEAD
- MAP4K
- MST
Ubiquitin
- Proteasome
- DUB
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- E2 conjugating
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- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- Gamma-secretase
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
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- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- Trk receptor
- CaMK
- NMDAR
- BACE
- GlyT
- Neurokinin Receptor
- Serotonin Transporter
- Notch
- Neurotensin Receptor
- CCK receptor
- Melanocortin Receptor
- NPY receptor
- Imidazoline Receptor
- COMT
- Adenosine Deaminase
- Adenosine Kinase
- BChE
- EAAT
- TRP Channel
- Sigma Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- ROS
- MALT
- Nrf2
- NOD
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- CaSR
- LTR
- Glucagon Receptor
- CXCR
- Adenosine Receptor
- cAMP
- Vasopressin Receptor
- TAAR
- GHSR
- GNRH Receptor
- FPR
- CRFR
- Bradykinin Receptor
- Neurokinin Receptor
- Bombesin Receptor
- AdipoR
- PKG
- Sigma Receptor
- Angiotensin Receptor
- Neurotensin Receptor
- Parathyroid Hormone Receptor
- RGS
- Melanocortin Receptor
- DOCK
- PAR
- NPY receptor
- GRK
- Imidazoline Receptor
- GPCR19
- Guanylate Cyclase
- TSH Receptor
- CCK receptor
- Leukotriene
- PKD
- Prostaglandin Receptor
- Taste Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- PGES
- TSH Receptor
- GNRH Receptor
- GHSR
- Mineralocorticoid Receptor
- ACE
- THR
- CCK receptor
- PGDS
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- OCT
- NMDAR
- GlyT
- GLUT
- CRM1
- VDAC
- NKCC
- MTP
- NCX
- VMAT
- GlyR
- BCRP
- MCT
- Amino acid transporter
- TRP Channel
- OAT
- OATP
- Aquaporin
- VRAC
- EAAT
- Mechanosensitive Channel
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Vitamin
- Thioredoxin
- phosphatase
- Lipoxygenase
- Lipase
- NAMPT
- FXR
- Retinoid Receptor
- Serine/threonin kinase
- Transferase
- IDO/TDO
- PKM
- HMG-CoA Reductase
- FOX
- Casein Kinase
- Fatty Acid Synthase
- GLUT
- CETP
- LDL
- Decarboxylase
- RUNX
- Adenosine Deaminase
- PGC-1α
- Serine hydrolase
- SCD
- Adenosine Kinase
- 3-MST
- LDH
- Mitochondrial Metabolism
- PDHK
- Catalase
- PAI-1
- Neprilysin
- Glucosylceramide Synthase
- FAO
- FTO
- γGCS
- GTPCH
- SREBP
- Leukotriene
- PARG
- Epoxide Hydrolase
- CPT
- PCSK9
- FTase
- Acetyl-CoA carboxylase
- PGDS
- ACE
- SGK
- ATP-citrate lyase
- Thioredoxin Reductase
- Carbohydrate Metabolism
- THR
- Mannosidase
- CPSase
- Xanthine Oxidase
- Glutathione
- Aldose Reductase
- Mitochondrial pyruvate carrier
- PREP
- OXPHOS
- glucocerebrosidase
- Peroxidases
- AdipoR
- FABP
- CAR
- PP2A
- ROR
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- Gamma-secretase
- HCV Protease
- DPP-4
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- MALT
- SGK
- PREP
- 3C-Like Protease
- PCSK9
- DPP-2
- PGDS
- Cathepsin B
- Neprilysin
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antibiotics
- β-lactamase
- Antiviral
- 3C-Like Protease
- Bacterial
- COVID-19
- Enterovirus
- Ribosomal Peptidyl Transferase
- Influenza Virus
- SARS-CoV
- RSV
- HPV
- HSV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Liver X Receptor

Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals

53 views | Jan 11 2022

Clémentine Garoche et al. demonstrated the importance of the use of species-specific models to study endocrine and metabolism disruption by environmental chemicals. [Read the Full Post]

Regulation of cytochrome P450 4F11 expression by liver X receptor alpha

204 views | Jan 21 2021

Tao Zhang et al. found that the regulation of CYP4F11 might contribute to the anti-inflammatory activity of LXRα agonists. [Read the Full Post]

Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury

0 views | Feb 12 2019

Wang Z et al. indicated that upregulation of SULT2B1b might promote HOC proliferation and aggravate liver injury via the suppression of oxysterol-induced LXR activation in chemically induced mouse liver injury. [Read the Full Post]

The LXR ligand GW3965 inhibits Newcastle disease virus infection by affecting cholesterol homeostasis

628 views | Sep 13 2018

Sheng XX et al. suggested that GW3965 inhibits NDV infection, probably by affecting cholesterol homeostasis. [Read the Full Post]

ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells

675 views | Jul 16 2018

Huang X et al. identified anti-ICAM-T0901317 liposomes as a promising nanotherapeutic approach to overcome VSMC proliferation during atherosclerosis progression. [Read the Full Post]