Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- PTEN
- MELK
- PP2A
- PIKfyve
- PI4K
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- DNA Methyltransferase
- Histone Demethylase
- Epigenetic Reader Domain
- Histone Acetyltransferase
- Histone Methyltransferase
- MLL
- JMJD
- NSD
- PRMT
- EZH1/2
- COMT
- LSD1
- FTO
- PAD
- MicroRNA
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
Methylation
- DNA Methyltransferase
- MAT2A
- COMT
- FTO
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
- JMJD
- PRMT
- EZH1/2
- LSD1
- NSD
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- COX
- CCR
- Histamine Receptor
- IL Receptor
- CXCR
- Anti-infection
- AhR
- NOD
- LTR
- IDO/TDO
- ROS
- MALT
- NADPH-oxidase
- Nrf2
- gp120/CD4
- TLR
- NOS
- Immunology & Inflammation related
- PGES
- PKR
- IFN
- AKR1C
- FLAP
- Heme Oxygenase
- MyD88
- cGAS
- STING
- Parasite
- Galectin
- Arginase
- Prostaglandin Receptor
- MmpL3
- MIF
- Nur77
- Glutathione
- Pyroptosis
- β-lactamase
- TBK1
- FKBP
- IRAK
- TpoR
- Complement System
- Interleukins
- Neuraminidase
- SPHK
- NLRP3
- eIF
- PGDS
- SIK
- TRIF
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- BTK
- ACK
- Ephrin receptor
- CSF-1R
- DYRK
- Trk receptor
- ETK/BMX
- RON
- Fer kinase
- Pyk2
- ROS1
- Mertk
- Axl
- Tyro3
- DDR
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- Bcl-2
- Caspase
- p53
- TNF-alpha
- Mdm2
- Survivin
- Ras
- c-RET
- RIP kinase
- PERK
- ASK
- IAP
- Ferroptosis
- Myc
- Nur77
- PFKFB
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- cytohesin
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- PKD
- FKBP
- DAPK
Autophagy
- Autophagy
- Nrf2
- CXCR
- LRRK2
- cGAS
- FKBP
- LC3
- ULK
- Mitophagy
- Heme Oxygenase
- OGA
ER stress & UPR
- JNK
- HSP (HSP90)
- PERK
- ASK
- IRE1
- ATF-6
- eIF
- PKR
- PDI
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TOPK
- ERK
- ASK
- KLF
- TAK1
- Mixed Lineage Kinase
- MNK
- MAPKAPK2
- MAP4K
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- Integrin
- MPS1
- Dynamin
- PAK
- Actin
- Gap-Junction
- PORCN
- TACC3
- MLCK
- Cardiac Myosin
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- Rho
- Serine/threonin kinase
- PERK
- MPS1
- PAK
- Casein Kinase
- DYRK
- Myc
- TOPK
- FOXM1
- Nur77
- TACC3
- PP2A
- RUNX
- PFKFB
- Haspin Kinase
- LIM kinase
- BMI-1
- eIF
- DOCK
- Mad2
- Choline kinase
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- RNR
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- FENs
- BMI-1
- Pax
- OGG1
- Thymidylate Synthase
- eIF
- G-quadruplex
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Gamma-secretase
- Hedgehog/Smoothened
- PKA
- ERK
- OCT
- KLF
- Stemness kinase
- Casein Kinase
- SFRP
- Fascin
- PORCN
- Notch
Hippo
- YAP
- TEAD
- MAP4K
- MST
Ubiquitin
- Proteasome
- DUB
- p97
- SUMO
- E2 conjugating
- E1 Activating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- Gamma-secretase
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- Trk receptor
- CaMK
- NMDAR
- BACE
- GlyT
- Neurokinin Receptor
- Serotonin Transporter
- Notch
- Neurotensin Receptor
- CCK receptor
- Melanocortin Receptor
- NPY receptor
- Imidazoline Receptor
- COMT
- Adenosine Deaminase
- Adenosine Kinase
- BChE
- EAAT
- TRP Channel
- Sigma Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- ROS
- MALT
- Nrf2
- NOD
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- CaSR
- LTR
- Glucagon Receptor
- CXCR
- Adenosine Receptor
- cAMP
- Vasopressin Receptor
- TAAR
- GHSR
- GNRH Receptor
- FPR
- CRFR
- Bradykinin Receptor
- Neurokinin Receptor
- Bombesin Receptor
- AdipoR
- PKG
- Sigma Receptor
- Angiotensin Receptor
- Neurotensin Receptor
- Parathyroid Hormone Receptor
- RGS
- Melanocortin Receptor
- DOCK
- PAR
- NPY receptor
- GRK
- Imidazoline Receptor
- GPCR19
- Guanylate Cyclase
- TSH Receptor
- CCK receptor
- Leukotriene
- PKD
- Prostaglandin Receptor
- Taste Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- PGES
- TSH Receptor
- GNRH Receptor
- GHSR
- Mineralocorticoid Receptor
- ACE
- THR
- CCK receptor
- PGDS
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- OCT
- NMDAR
- GlyT
- GLUT
- CRM1
- VDAC
- NKCC
- MTP
- NCX
- VMAT
- GlyR
- BCRP
- MCT
- Amino acid transporter
- TRP Channel
- OAT
- OATP
- Aquaporin
- VRAC
- EAAT
- Mechanosensitive Channel
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Vitamin
- Thioredoxin
- phosphatase
- Lipoxygenase
- Lipase
- NAMPT
- FXR
- Retinoid Receptor
- Serine/threonin kinase
- Transferase
- IDO/TDO
- PKM
- HMG-CoA Reductase
- FOX
- Casein Kinase
- Fatty Acid Synthase
- GLUT
- CETP
- LDL
- Decarboxylase
- RUNX
- Adenosine Deaminase
- PGC-1α
- Serine hydrolase
- SCD
- Adenosine Kinase
- 3-MST
- LDH
- Mitochondrial Metabolism
- PDHK
- Catalase
- PAI-1
- Neprilysin
- Glucosylceramide Synthase
- FAO
- FTO
- γGCS
- GTPCH
- SREBP
- Leukotriene
- PARG
- Epoxide Hydrolase
- CPT
- PCSK9
- FTase
- Acetyl-CoA carboxylase
- PGDS
- ACE
- SGK
- ATP-citrate lyase
- Thioredoxin Reductase
- Carbohydrate Metabolism
- THR
- Mannosidase
- CPSase
- Xanthine Oxidase
- Glutathione
- Aldose Reductase
- Mitochondrial pyruvate carrier
- PREP
- OXPHOS
- glucocerebrosidase
- Peroxidases
- AdipoR
- FABP
- CAR
- PP2A
- ROR
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- Gamma-secretase
- HCV Protease
- DPP-4
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- MALT
- SGK
- PREP
- 3C-Like Protease
- PCSK9
- DPP-2
- PGDS
- Cathepsin B
- Neprilysin
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antibiotics
- β-lactamase
- Antiviral
- 3C-Like Protease
- Bacterial
- COVID-19
- Enterovirus
- Ribosomal Peptidyl Transferase
- Influenza Virus
- SARS-CoV
- RSV
- HPV
- HSV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

DNA Methyltransferase

Randomized phase 2 study of low-dose decitabine vs low-dose azacitidine in lower-risk MDS and MDS/MPN

849 views | Mar 10 2019

Jabbour E et al. indicated that treatment was well tolerated, with a 6-week mortality rate of 0%. The use of low-dose HMAs is safe and effective in patients with lower-risk MDS and MDS/MPN. Their effect on the natural history of lower-risk disease needs to be further studied. [Read the Full Post]

Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia

896 views | Nov 18 2018

Gopalakrishnapillai A et al. indicated the expression of mutant p53 in MV4;11 cells reduced sensitivity to azacitidine-panobinostat combination, suggesting that p53 may be a predictor of response to epigenetic therapy in pediatric AML. [Read the Full Post]

Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple myeloma.

871 views | Oct 12 2018

Tatekawa S et al. showed the universal involvement of overlapping epigenetic dysregulation for abnormal miR-375 repression in MM, which is likely to contribute to myelomagenesis and to subsequent myeloma progression by activating oncogenic signalling pathways. [Read the Full Post]

Multi-omics maps of cotton fibre reveal epigenetic basis for staged single-cell differentiation

1065 views | May 06 2018

Wang M et al. illustrated two divergent pathways mediating a continuous increase of DNA methylation and also sheds further light on the epigenetic basis for single-cell differentiation in plants. [Read the Full Post]