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Hedgehog/Smoothened

"Petal-like" size-tunable gold wrapped immunoliposome to enhance tumor deep penetration for multimodal guided two-step strategy

12 views | Oct 11 2021

Yanan Li et al. provided a synergistic treatment strategy that could broaden the conventional treatment alone. [Read the Full Post]

Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial

77 views | Aug 12 2021

Alexander J Stratigos et al. found that cemiplimab exhibited clinically meaningful antitumour activity and an acceptable safety profile in patients with locally advanced basal cell carcinoma after HHI therapy. [Read the Full Post]

MLN4924 inhibits hedgehog signaling pathway and activates autophagy to alleviate mouse laser-induced choroidal neovascularization lesion

75 views | Aug 09 2021

Laiqing Xie et al. found that MLN4924 relieved the formation of mouse laser-induced CNV lesion might via up-regulating hedgehog pathway-regulated autophagy. [Read the Full Post]

β-Sitosterol-D-Glucopyranoside Mimics Estrogenic Properties and Stimulates Glucose Utilization in Skeletal Muscle Cells

92 views | Jun 03 2021

Jyotsana Pandey et al. found the estrogenic activity of BSD to stimulate glucose utilization in skeletal muscle cells via PI-3K/AKT-dependent mechanism. [Read the Full Post]

The Role of Actin in Muscle Spasms in a Case Series of Patients with Advanced Basal Cell Carcinoma Treated with a Hedgehog Pathway Inhibitor

99 views | Jan 03 2021

Natalie Teh et al. presented a case series of patients with muscle spasms during treatment with sonidegib and proposed an alternate etiology related to increased actin expression. [Read the Full Post]

A Vismodegib Experience in Elderly Patients with Basal Cell Carcinoma: Case Reports and Review of the Literature

107 views | Jan 02 2021

Anna Passarelli et al. reported two case reports of BCC elderly patients in order to demonstrate both efficacy and safety of the Hedgehog inhibitors. [Read the Full Post]

Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG

130 views | Dec 28 2020

Huan Zhao et al. found that Gli and NANOG might be effective indicators of platinum resistance and prognosis in EOC. [Read the Full Post]

Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health

108 views | Oct 13 2020

Sen Yin et al.demonstrated that activation of the Shh signaling pathway played a neuroprotective role in response to ischemic exposure via promotion of synaptic and neuronal health. [Read the Full Post]

Cohort analysis of safety and efficacy of vismodegib in Italian patients from the Phase II, multicenter STEVIE study

177 views | Jul 19 2020

Paolo Bossi et al. showed a safety profile consistent with the whole population; older age did not affect safety or efficacy. [Read the Full Post]

Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells

185 views | Jul 14 2020

Tamara Scheidt et al. provided evidence that phosphorylation triggered in response to SMO modulation dictated the localization of hedgehog pathway components within the primary cilium and affected the regulation of the SMO-SUFU-GLI axis. [Read the Full Post]