Blog of Signaling Pathways

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

24 views | Jul 08 2023

This study highlights the significant involvement of FUT8-mediated core fucosylation in pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), suggesting FUT8 as a potential novel therapeutic target for PAH. [Read the Full Post]

Case Report: Identification of a novel NTRK3-AJUBA fusion co-existing with ETV6-NTRK3 fusion in papillary thyroid carcinoma

97 views | Jul 08 2023

This study reports the identification of a novel NTRK3-AJUBA fusion co-existing with a known ETV6-NTRK3 fusion in thyroid cancer, expanding the spectrum of translocation partners and highlighting the importance of further investigation regarding the impact of dual NTRK3 fusion on TRK inhibitor therapy and prognosis. [Read the Full Post]

Larotrectinib versus historical standard of care in patients with infantile fibrosarcoma: protocol of EPI-VITRAKVI

89 views | Jul 08 2023

The EPI VITRAKVI study is a retrospective study that compares the time to medical treatment failure between larotrectinib and chemotherapy in patients with infantile fibrosarcoma using external historical controls and adjusting for potential confounding using the Inverse Probability of Treatment Weighting method. [Read the Full Post]

Comparative transcriptome profile of mouse macrophages treated with the RhoA/Rock pathway inhibitors Y27632, Fingolimod (Gilenya), and Rezurock (Belumosudil, SLx-2119)

39 views | Jul 07 2023

The transcriptome profiling study comparing macrophages treated with Y27632, Fingolimod, and Rezurock revealed distinct downregulation of GTPase and actin pathways in cell migration for Y27632 and Fingolimod, while Rezurock specifically downregulated fibrosis-related genes, providing insights into the differences in their anti-chronic rejection properties and aiding in the development of targeted therapies. [Read the Full Post]

Discovery of indoline-based derivatives as effective ROCK2 inhibitors for the potential new treatment of idiopathic pulmonary fibrosis

91 views | Jul 07 2023

A new series of selective ROCK2 inhibitors based on indoline, particularly compound 9b, showed promising results in inhibiting collagen gel contraction, suppressing fibrotic markers, and exhibiting anti-pulmonary fibrosis effects in a bleomycin-induced IPF rat model, suggesting its potential as a lead compound for IPF treatment. [Read the Full Post]

Evaluation of the Effectiveness of Various Autophagy Inhibitors in A549 Cancer Stem Cells

33 views | Jul 07 2023

Autophinib, among the panel of autophagy inhibitors tested, demonstrated a significant toxic effect on cancer stem cells by downregulating Sox2 expression, inducing apoptosis, and reducing stemness in A549 cells. [Read the Full Post]

Molecular and neuroimmune pharmacology of S1P receptor modulators and other disease-modifying therapies for multiple sclerosis

34 views | Jul 07 2023

Multiple sclerosis (MS) is a neurological disease where immune-mediated damage to the central nervous system (CNS) occurs, and while disease-modifying therapies primarily target immunomodulation, sphingosine 1-phosphate receptor (S1PR) modulators like fingolimod also exhibit direct effects on the CNS, potentially reducing neurodegenerative consequences. [Read the Full Post]

Natural Compounds, Optimal Combination of Brusatol and Polydatin Promote Anti-Tumor Effect in Breast Cancer by Targeting Nrf2 Signaling Pathway

86 views | Jul 07 2023

The combination of brusatol (BRU) and polydatin (PD) effectively inhibits cell proliferation, downregulates Nrf2 and its downstream target genes, promotes reactive oxygen species (ROS) accumulation, and reduces tumor cell growth in triple-negative breast cancer (TNBC) both in vitro and in vivo, offering a potentially more efficient and less toxic treatment strategy. [Read the Full Post]

SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling

19 views | Jul 06 2023

PAI-1-induced TNBC metastasis is regulated by the lncRNA SOX2-OT through its interaction with miR-942-5p and subsequent activation of the PI3K/Akt signaling pathway, highlighting the potential for targeted therapies against SOX2-OT in TNBC. [Read the Full Post]

Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function

37 views | Jul 06 2023

This study showed that formulating S-(-)-Bay K8644 (BayK) within lymph-draining nanoparticles (NPs) improved lymphatic vessel function and effectively treated lymphatic dysfunction, providing a promising therapeutic approach. [Read the Full Post]

Blockade of mutant RAS oncogenic signaling with a special emphasis on KRAS

43 views | Jul 06 2023

RAS proteins, including KRAS, HRAS, and NRAS, function as GTPases and play crucial roles in cell signaling pathways involved in growth, division, and survival, with RAS mutations being common in various cancers, particularly KRAS mutations in lung, colorectal, and pancreatic cancers. [Read the Full Post]

Investigations into the Signaling Pathways Involving Glucose-Stimulated Zinc Secretion (GSZS) from Prostate Epithelial Cells In Vitro and In Vivo

21 views | Jul 06 2023

Exposure of prostate cells to high glucose leads to glucose-stimulated zinc secretion (GSZS) both in vitro and in vivo, requiring glycolytic flux and involving the activation of specific signaling pathways. [Read the Full Post]

Targeting of Glucose Transport and the NAD Pathway in Neuroendocrine Tumor (NET) Cells Reveals New Treatment Options

29 views | Jul 06 2023

In this study, the effectiveness of glucose transporter (GLUT) and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as potential treatments for neuroendocrine tumors (NET) was demonstrated through significant effects on tumor cell proliferation and survival rates. [Read the Full Post]

A retrospective cohort study on the efficacy and safety for combination therapy of immunotherapy, targeted agent, and chemotherapy versus immunochemotherapy or chemotherapy alone in the first-line treatment of advanced biliary tract carcinoma

28 views | Jul 05 2023

This retrospective study suggests that combining anti-PD-1/PD-L1 immunotherapy with anlotinib and gemcitabine shows promising efficacy and an acceptable safety profile in patients with advanced biliary tract carcinoma. [Read the Full Post]

Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β-catenin signalling and promotes hair regrowth

80 views | Jul 05 2023

The study identified ISX9 as a novel activator of the Wnt/β-catenin pathway, promoting hair regrowth and suggesting its potential as a therapeutic agent for alopecia treatment. [Read the Full Post]

ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude

49 views | Jul 05 2023

ISX-9, a neurogenic small molecule, has shown promising effects in improving circadian amplitude, metabolic rhythms, sleep homeostasis, and locomotive activity, making it a potential candidate for treating circadian-related disorders. [Read the Full Post]

On-chip real-time impedance monitoring of hiPSC-derived and artificial basement membrane-supported endothelium

138 views | Jul 05 2023

Electrochemical impedance spectroscopy was successfully applied to monitor the stability and integrity of a human induced pluripotent stem cell-derived endothelial barrier supported by an artificial basement membrane, revealing enhanced stability in a serum-free and bromodeoxyuridine-containing culture medium and sensitivity to stimuli such as thrombin. [Read the Full Post]

Anti-tumor effects of perampanel in malignant glioma cells

56 views | Jul 05 2023

Perampanel, an antiepileptic drug, demonstrates potential antitumoral effects by inducing apoptosis and reducing cell viability, particularly when combined with temozolomide, in certain malignant glioma cell lines, suggesting new therapeutic strategies for the treatment of glioblastoma. [Read the Full Post]

The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE2-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model

13 views | Jul 04 2023

The study found that SW033291 treatment improved glucose metabolism, reduced lipid levels, and ameliorated insulin resistance in a T2DM mouse model, indicating its potential as a novel therapeutic agent for T2DM. [Read the Full Post]

Fangchinoline Exerts Anticancer Effects on Colorectal Cancer Cells by Evoking Cell Apoptosis via Endoplasmic Reticulum Stress

93 views | Jul 04 2023

Fangchinoline (FAN) induces apoptosis in human colorectal cancer cells by activating endoplasmic reticulum stress through the upregulation of ER stress-related proteins and the involvement of the CHOP pathway. [Read the Full Post]