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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Estrogen/progestogen Receptor

Effect of follicular wave synchronization using a progesterone-releasing intravaginal device-based protocol on in vitro embryo production in Bos taurus cows subjected to 14-day intervals ovum pick-up

231 views | Feb 11 2024

The study highlighted that follicular wave synchronization in Angus cows before ovum pick-up enhanced embryo quality while revealing sustained carryover effects on follicle numbers and cumulus-oocyte complex morphology. [Read the Full Post]

The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation

326 views | Nov 30 2023

Saiga antelope horn (SAH) demonstrates significant anticonvulsant effects in a febrile seizures rat model by modulating neurotransmitter levels, exerting anti-inflammatory actions, and activating the ER-β/TPH2/5-HT signaling pathway, offering potential insights for the development of SAH-based treatments and substitutes. [Read the Full Post]

Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer

227 views | Oct 06 2023

In older women with non-metastatic breast cancer, higher concentrations of tamoxifen and its metabolites were observed, independent of CYP2D6 and CYP3A4 gene polymorphisms, but these differences did not have a significant impact on clinical outcomes. [Read the Full Post]

An overview of PROTACs: a promising drug discovery paradigm

0 views | Sep 25 2023

This review provides a comprehensive analysis of the features of PROTAC technology, principles for designing efficient PROTACs, their applications across different protein categories, progress in clinical trials, and the challenges and limitations they may face, serving as a valuable reference for further advancements in PROTAC research and application. [Read the Full Post]

Phase 1 study of oral selective estrogen receptor degrader (SERD) amcenestrant (SAR439859), in Japanese women with ER-positive and HER2-negative advanced breast cancer (AMEERA-2)

195 views | Sep 16 2023

The AMEERA-2 study found that amcenestrant 400 mg QD demonstrated favorable safety and efficacy, leading to its selection as the recommended Phase II dose for monotherapy in a larger clinical trial for metastatic breast cancer. [Read the Full Post]

Design of SERENA-6, a phase III switching trial of camizestrant in ESR1-mutant breast cancer during first-line treatment

364 views | Sep 12 2023

The SERENA-6 study is a phase III trial evaluating the efficacy and safety of switching from an aromatase inhibitor to camizestrant, while maintaining the same CDK4/6 inhibitor treatment, in HR+/HER2- advanced breast cancer patients with ESR1 mutations, with the primary endpoint being progression-free survival. [Read the Full Post]

Evaluation of mitochondrial oxidative toxicity in mammalian cardiomyocytes by determining the highly reproducible and reliable increase in mitochondrial superoxides after exposure to therapeutic drugs

0 views | Sep 11 2023

The study demonstrated that increased MitoSOX™ red fluorescence following drug exposure is a reliable biomarker for evaluating mitochondrial-specific oxidative toxicity in cardiomyocytes, offering potential applications in new drug development. [Read the Full Post]

5-Oxoproline Enhances 4-Hydroxytamoxifen-induced Cytotoxicity by Increasing Oxidative Stress in MCF-7 Breast Cancer Cells

0 views | Jul 01 2023

In conclusion, the study demonstrates that 5-oxoproline enhances the cytotoxic effects of 4-hydroxytamoxifen in estrogen receptor-positive breast cancer cells under normal glucose conditions, suggesting the potential utility of monocarboxylate transporter inhibitors as adjunctive therapeutic agents. [Read the Full Post]

Generation of a Live Attenuated Influenza A Vaccine Using Chemical-Triggered Intein

443 views | Jul 01 2023

A novel method using 4-hydroxytamoxifen (4-HT)-dependent intein insertion into the polymerase acidic (PA) protein of influenza A virus generates recombinant viruses that demonstrate excellent replication characteristics and induce robust immunity, offering potential for the development of a more effective live attenuated influenza vaccine and possibly vaccines against other pathogens as well. [Read the Full Post]

Quality by Design (QbD)-Steered Development and Validation of Analytical and Bioanalytical Methods for Raloxifene: Application of Monte Carlo Simulations and Variance Inflation Factor

312 views | May 05 2023

The study developed and validated a sensitive, rapid, reproducible, and economical HPLC method for quantifying raloxifene hydrochloride using QbD principles, and demonstrated its applicability for drug quantification in biological fluids, as well as in bulk and marketed dosage forms. [Read the Full Post]