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Archives
Mixed Lineage Kinase
The Role of Syk in Inflammatory Response of Human Abdominal Aortic Aneurysm Tissue
0 views | Dec 01 2021
Ryo Kanamoto et al. found an important role of Syk for IgG-dependent inflammatory response in human AAA. [Read the Full Post]
Spleen tyrosine kinase (SYK) inhibitor PRT062607 protects against ovariectomy-induced bone loss and breast cancer-induced bone destruction
706 views | Nov 30 2021
Gang Xie et al. suggested the potential value of PRT in managing osteolytic diseases mediated by osteoclasts. [Read the Full Post]
MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms
686 views | Nov 25 2021
Timothy D Calamaras et al. suggested augmenting MLK3 kinase activity could preserve LV function in HF but avoid hypotension from PKG1α activation. [Read the Full Post]
The Role of Syk in Inflammatory Response of Human Abdominal Aortic Aneurysm Tissue
1271 views | Dec 13 2020
Ryo Kanamoto et al. demonstrated an important role of Syk for IgG-dependent inflammatory response in human AAA. [Read the Full Post]
Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis
0 views | Dec 12 2020
Alejandro Torres-Hernandez et al. found that SYK is an attractive target for experimental therapeutics in treating hepatic fibrosis and oncogenesis. [Read the Full Post]
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity
868 views | Dec 07 2020
Sandeep Kumar et al. demonstrated that MLK3 played an important role in T cell biology, and targeting MLK3 could serve as a potential therapeutic intervention via increasing T cell cytotoxicity in cancer. [Read the Full Post]
URMC-099 Facilitates Amyloid-β Clearance in a Murine Model of Alzheimer's Disease
1091 views | Mar 01 2020
Tomomi Kiyota et al. indicated that URMC-099 facilitates Aβ clearance in the brain of APP/PS1 mice. The multifaceted immune modulatory and neuroprotective roles of URMC-099 make it an attractive candidate for ameliorating the course of AD. This is buttressed by removal of pathologic Aβ species and restoration of the brain's microenvironment during disease. [Read the Full Post]
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