Category
- PI3K/Akt/mTOR
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- Protein Tyrosine Kinase
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Archives
Endothelin Receptor
IL27 controls skin tumorigenesis via accumulation of ETAR-positive CD11b cells in the pre-malignant skin
198 views | Dec 31 2018
Dibra D et al. indicated that these findings are clinically relevant, as the number of IL27RA-positive cells in the stroma is highly related to tumor de-differentiation in patients with squamous cell carcinomas. [Read the Full Post]
Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer
0 views | Oct 14 2018
Bhattacharya B et al. highlight that AQR to combination treatment may develop through alternative mechanisms to those of single agent treatment, including a change in drug interaction. [Read the Full Post]
Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1
417 views | May 12 2018
Wermuth PJ et al. suggested a novel role for ET-1 in the establishment and progression of tissue fibrosis. [Read the Full Post]
Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice
0 views | Mar 21 2018
Dibra D et al. found that he combination of mutant p53 and IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis in vivo, whereas either gene alone in vivo has no effects on the liver. [Read the Full Post]
Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice
1077 views | Feb 22 2017
The combination of mutant p53 and IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis in vivo, whereas either gene alone in vivo has no effects on the liver. [Read the Full Post]
Sorafenib Tosylate is a multikinase inhibitor
2597 views | Dec 13 2012
Sorafenib acute HCV infection leads to chronic infection in approximately 80% of cases. Chronic HCV infection is responsible for chronic hepatitis,which is complicated by cirrhosis in approximately 20% of cases. [Read the Full Post]
Nelson, J., A. Bagnato, et al. (2003). "The endothelin axis: emerging role in cancer." Nat Rev Cancer 3(2): 110-116.
3010 views | Mar 17 2011
The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation. [Read the Full Post]
