SIK

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

10 views | Nov 26 2023

The study reveals that SIK3 functions as a crucial phosphorylation switch for β-adrenergic activation, driving the adipose tissue thermogenic program, offering potential therapeutic avenues for obesity and related cardiometabolic diseases. [Read the Full Post]

High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs

49 views | Nov 04 2022

Doris Kafita et al. found that we could devise novel categorisation of patient tumours, treatment, and prognostic strategies. [Read the Full Post]

Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia

0 views | Dec 12 2021

Valentina Serafin et al. found that GC-sensitive cells cultured with IL-4 displayed an increased resistance to dexamethasone, whereas the inhibition of IL-4 signaling could increase GC-induced apoptosis in resistant cells. [Read the Full Post]